Interactions between a Bioflavonoid and c-MYC Promoter G-Quadruplex DNA: Ensemble and Single-Molecule Investigations

2019 ◽  
Vol 123 (9) ◽  
pp. 2022-2031 ◽  
Author(s):  
Sneha Paul ◽  
Sk Saddam Hossain ◽  
Bala Divya M ◽  
Anunay Samanta
Keyword(s):  
Single Molecule ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Characterizing the Binding of G-Quadruplex DNA to Insulin by Single Molecule and Bulk Ensemble Methods

2012 ◽  
Vol 102 (3) ◽  
pp. 75a
Author(s):  
Christine Timmer ◽  
Amanda Witte ◽  
Niecia Flikweert ◽  
Kumar Sinniah
Keyword(s):  
Single Molecule ◽  
Ensemble Methods ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals The Binding of G‐Quadruplex DNA to Insulin: From Single Molecule to Bulk‐Methods

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Kumar Sinniah ◽  
Susanna Lynch ◽  
Christine Timmer ◽  
Amanda Witte
Keyword(s):  
Single Molecule ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals A Single Molecule Force Spectroscopy Study of the Binding Interaction Between Insulin and G-Quadruplex DNA

2010 ◽  
Vol 98 (3) ◽  
pp. 592a
Author(s):  
Susanna Lynch ◽  
Rachel Battershell ◽  
Jordan Scott ◽  
Dejian Zhou ◽  
Kumar Sinniah
Keyword(s):  
Single Molecule ◽  
Force Spectroscopy ◽  
Spectroscopy Study ◽  
Binding Interaction ◽  
Single Molecule Force Spectroscopy ◽  
Quadruplex Dna ◽  
G Quadruplex

A single-molecule force-spectroscopic study on stabilization of G-quadruplex DNA by a telomerase inhibitor

The Analyst ◽  
2014 ◽  
Vol 139 (16) ◽  
pp. 4037-4043 ◽  
Author(s):  
Ryoto Funayama ◽  
Yoshio Nakahara ◽  
Shinpei Kado ◽  
Mutsuo Tanaka ◽  
Keiichi Kimura
Keyword(s):  
Spectroscopic Study ◽  
Single Molecule ◽  
Quadruplex Dna ◽  
Telomerase Inhibitor ◽  
G Quadruplex

The stabilization of G-quadruplex DNA by a telomerase inhibitor was semi-quantitatively evaluated by AFM-based SMFS.

scholarly journals Single Molecule Force Spectroscopy on G-Quadruplex DNA

2009 ◽  
Vol 15 (33) ◽  
pp. 8113-8116 ◽  
Author(s):  
Susanna Lynch ◽  
Heather Baker ◽  
Sarah G. Byker ◽  
Dejian Zhou ◽  
Kumar Sinniah
Keyword(s):  
Single Molecule ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy ◽  
Quadruplex Dna ◽  
G Quadruplex

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex
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