Melting Transition of Oriented DNA Fibers Submerged in Poly(ethylene glycol) Solutions Studied by Neutron Scattering and Calorimetry

2018 ◽  
Vol 122 (9) ◽  
pp. 2504-2515 ◽  
Author(s):  
Adrián González ◽  
Andrew Wildes ◽  
Marta Marty-Roda ◽  
Santiago Cuesta-López ◽  
Estelle Mossou ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Neutron Scattering ◽  
Melting Transition ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
And Calorimetry

“Design of Poly(ethylene glycol)-Polycaprolactone Diblock Micelles with RGD Targeting Ligands and Embedded Iron Oxide Nanoparticles for Thermally-activated Release”

2012 ◽  
Vol 1416 ◽  
Author(s):  
Christopher S. Brazel ◽  
James B. Bennett ◽  
Amanda L. Glover ◽  
Jacqueline A. Nikles ◽  
Maaike Everts ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Melting Transition ◽  
Release Mechanism ◽  
Poly Ethylene Glycol ◽  
Rgd Peptides ◽  
Thermally Activated ◽  
Poly Ethylene

ABSTRACTA thermally-activated micelle consisting of a crystallizable poly(caprolactone), PCL, core and a poly(ethylene glycol), PEG, corona was developed to contain magnetic nanoparticles and anti-cancer agent doxorubicin as well as display a targeting RGD peptide. This system has the potential to target cancer cells, deliver combination hyperthermia and chemotherapy, and offer magnetic resonance imaging contrast. The micelles self-assemble in aqueous solutions and form a crystalline core with a melting transition ranging from 40 to 50 °C, depending on the length of the PCL blocks, with dynamic light scattering showing micelle sizes typically ranging from 20 to 100 nm, depending on block lengths and added drug or nanoparticles. The micelles become unstable as they are heated above their melting point, creating a thermally-activated drug release mechanism. By adding magnetite (Fe3O4) nanoparticles into the PCL core, the micelles can be heated using an externally applied AC magnetic field to induce hyperthermia in combination with the thermally-activated drug release. The polymers and magnetic nanoparticles (MNPs) were synthesized and characterized in our laboratories. The melting transitions of the PCL micelle cores were investigated using microcalorimetry. The heating of nanoparticles and magnetomicelles was conducted using a custom-built hyperthermia coil capable of generating fields of several hundred Oersteds at frequencies ranging from 50 to 450 kHz. Heating of MNPs was maximized at high field intensities. RGD peptides were attached to the PEG corona using maleimide chemistry, and the ability of the RGD-derivatized micelles to target integrin-expressing cells was investigated using fluorescent dye PKH26 to identify the localization of micelles in cultured human kidney (293) cells in vitro. The crystallizable (and meltable) cores in these micelles were designed to overcome drug leakage common in liposome systems and release the drug on demand after a period of time for localization to integrin receptors.

Small-angle neutron scattering studies on water soluble complexes of poly(ethylene glycol)-based cationic random copolymer and SDS

Pramana ◽  
2004 ◽  
Vol 63 (2) ◽  
pp. 315-320
Author(s):  
C. K. Nisha ◽  
Sunkara V. Manorama ◽  
Souvik Maiti ◽  
K. N. Jayachandran ◽  
V. K. Aswald ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Neutron Scattering ◽  
Small Angle ◽  
Small Angle Neutron Scattering ◽  
Random Copolymer ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Soluble Complexes

Structure and Interaction of Poly(ethylene glycol) in Aqueous Solutions. Small-Angle Neutron Scattering Data

2014 ◽  
Vol 335 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Viktor Petrenko ◽  
Leonid Bulavin ◽  
Mikhail Avdeev ◽  
Vasil Garamus ◽  
Martina Koneracka ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Aqueous Solutions ◽  
Neutron Scattering ◽  
Small Angle ◽  
Small Angle Neutron Scattering ◽  
Scattering Data ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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