Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors

Satoshi Yasuda; Yuta Kajiwara; Yosuke Toyoda; Kazushi Morimoto; Ryoji Suno; So Iwata; Takuya Kobayashi; Takeshi Murata; Masahiro Kinoshita

doi:10.1021/acs.jpcb.7b02997

Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.7b02997 ◽

2017 ◽

Vol 121 (26) ◽

pp. 6341-6350 ◽

Cited By ~ 20

Author(s):

Satoshi Yasuda ◽

Yuta Kajiwara ◽

Yosuke Toyoda ◽

Kazushi Morimoto ◽

Ryoji Suno ◽

...

Keyword(s):

G Protein ◽

Hot Spot ◽

Three Dimensional ◽

G Protein Coupled Receptors ◽

Class A ◽

G Protein Coupled

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Hot-Spot Residues to Be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors

Biophysical Journal ◽

10.1016/j.bpj.2017.11.1309 ◽

2018 ◽

Vol 114 (3) ◽

pp. 235a

Author(s):

Satoshi Yasuda ◽

Yuta Kajiwara ◽

Yosuke Toyoda ◽

Kazushi Morimoto ◽

Ryoji Suno ◽

...

Keyword(s):

G Protein ◽

Hot Spot ◽

Three Dimensional ◽

G Protein Coupled Receptors ◽

Class A ◽

G Protein Coupled

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Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)†,‡

Biochemistry ◽

10.1021/bi0155091 ◽

2001 ◽

Vol 40 (26) ◽

pp. 7761-7772 ◽

Cited By ~ 449

Author(s):

David C. Teller ◽

Tetsuji Okada ◽

Craig A. Behnke ◽

Krzysztof Palczewski ◽

Ronald E. Stenkamp

Keyword(s):

High Resolution ◽

G Protein ◽

Three Dimensional ◽

G Protein Coupled Receptors ◽

Dimensional Structure ◽

Three Dimensional Structure ◽

G Protein Coupled

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Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

PLoS ONE ◽

10.1371/journal.pone.0138463 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0138463 ◽

Cited By ~ 53

Author(s):

Adam L. Martin ◽

Michael A. Steurer ◽

Robert S. Aronstam

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

Constitutive Activity ◽

Class A ◽

G Protein Coupled

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G-Protein-Coupled Receptors for Light: The Three-Dimensional Structure of Rhodopsin

ChemBioChem ◽

10.1002/1439-7633(20010803)2:7/8<513::aid-cbic513>3.0.co;2-x ◽

2001 ◽

Vol 2 (7-8) ◽

pp. 513-516 ◽

Cited By ~ 2

Author(s):

Lars-Oliver Essen

Keyword(s):

G Protein ◽

Three Dimensional ◽

G Protein Coupled Receptors ◽

Dimensional Structure ◽

Three Dimensional Structure ◽

G Protein Coupled

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FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.22731 ◽

2010 ◽

Vol 78 (10) ◽

pp. 2189-2201 ◽

Cited By ~ 26

Author(s):

Mayako Michino ◽

Jianhan Chen ◽

Raymond C. Stevens ◽

Charles L. Brooks

Keyword(s):

G Protein ◽

Structure Prediction ◽

Transmembrane Domain ◽

G Protein Coupled Receptors ◽

Class A ◽

G Protein Coupled

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Frontispiece: Universality of the Sodium Ion Binding Mechanism in Class A G-Protein-Coupled Receptors

Angewandte Chemie International Edition ◽

10.1002/anie.201881261 ◽

2018 ◽

Vol 57 (12) ◽

Author(s):

Balaji Selvam ◽

Zahra Shamsi ◽

Diwakar Shukla

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

Sodium Ion ◽

Ion Binding ◽

Binding Mechanism ◽

Class A ◽

G Protein Coupled

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Homology Modeling of Class A G-Protein-Coupled Receptors in the Age of the Structure Boom

Methods in Molecular Biology - Computational Design of Membrane Proteins ◽

10.1007/978-1-0716-1468-6_5 ◽

2021 ◽

pp. 73-97

Author(s):

Asma Tiss ◽

Rym Ben Boubaker ◽

Daniel Henrion ◽

Hajer Guissouma ◽

Marie Chabbert

Keyword(s):

Homology Modeling ◽

G Protein ◽

G Protein Coupled Receptors ◽

Class A ◽

G Protein Coupled

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Importance of protein dynamics in the structure-based drug discovery of class A G protein-coupled receptors (GPCRs)

Current Opinion in Structural Biology ◽

10.1016/j.sbi.2019.03.015 ◽

2019 ◽

Vol 55 ◽

pp. 147-153 ◽

Cited By ~ 12

Author(s):

Yoonji Lee ◽

Raudah Lazim ◽

Stephani Joy Y Macalino ◽

Sun Choi

Keyword(s):

Drug Discovery ◽

Protein Dynamics ◽

G Protein ◽

G Protein Coupled Receptors ◽

Class A ◽

G Protein Coupled

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Universality of the Sodium Ion Binding Mechanism in Class A G-Protein-Coupled Receptors

Angewandte Chemie ◽

10.1002/ange.201708889 ◽

2018 ◽

Vol 130 (12) ◽

pp. 3102-3107 ◽

Cited By ~ 9

Author(s):

Balaji Selvam ◽

Zahra Shamsi ◽

Diwakar Shukla

Keyword(s):

G Protein ◽

G Protein Coupled Receptors ◽

Sodium Ion ◽

Ion Binding ◽

Binding Mechanism ◽

Class A ◽

G Protein Coupled

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G protein-coupled receptors of class A harness the energy of membrane potential to increase their sensitivity and selectivity

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/j.bbamem.2019.183051 ◽

2019 ◽

Vol 1861 (12) ◽

pp. 183051 ◽

Cited By ~ 4

Author(s):

Daria N. Shalaeva ◽

Dmitry A. Cherepanov ◽

Michael Y. Galperin ◽

Gert Vriend ◽

Armen Y. Mulkidjanian

Keyword(s):

Membrane Potential ◽

G Protein ◽

G Protein Coupled Receptors ◽

Class A ◽

Sensitivity And Selectivity ◽

G Protein Coupled

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