Facilitated Diffusion of Transcription Factor Proteins with Anomalous Bulk Diffusion

2017 ◽  
Vol 121 (6) ◽  
pp. 1284-1289 ◽  
Author(s):  
Lin Liu ◽  
Andrey G. Cherstvy ◽  
Ralf Metzler
Keyword(s):  
Transcription Factor ◽  
Bulk Diffusion ◽  
Facilitated Diffusion ◽  
Transcription Factor Proteins

scholarly journals Divergent Roles of a Pair of Homologous Jumonji/Zinc-Finger–Class Transcription Factor Proteins in the Regulation of Arabidopsis Flowering Time

2004 ◽  
Vol 16 (10) ◽  
pp. 2601-2613 ◽  
Author(s):  
Bosl Noh ◽  
Seung-Hee Lee ◽  
Hyun-Jin Kim ◽  
Gibum Yi ◽  
Eun-Ah Shin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Flowering Time ◽  
Zinc Finger ◽  
Transcription Factor Proteins

scholarly journals Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Dave W Anderson ◽  
Alesia N McKeown ◽  
Joseph W Thornton
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Binding Sites ◽  
Steroid Hormone Receptor ◽  
Biological Processes ◽  
Epistatic Interactions ◽  
Dna Binding Sites ◽  
Evolutionary Paths ◽  
Historical Transition ◽  
Transcription Factor Proteins

Complexes of specifically interacting molecules, such as transcription factor proteins (TFs) and the DNA response elements (REs) they recognize, control most biological processes, but little is known concerning the functional and evolutionary effects of epistatic interactions across molecular interfaces. We experimentally characterized all combinations of genotypes in the joint protein-DNA sequence space defined by an historical transition in TF-RE specificity that occurred some 500 million years ago in the DNA-binding domain of an ancient steroid hormone receptor. We found that rampant epistasis within and between the two molecules was essential to specific TF-RE recognition and to the evolution of a novel TF-RE complex with unique derived specificity. Permissive and restrictive epistatic mutations across the TF-RE interface opened and closed potential evolutionary paths accessible by the other, making the evolution of each molecule contingent on its partner's history and allowing a molecular complex with novel specificity to evolve.

scholarly journals Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins

2018 ◽  
Vol 9 ◽  
Author(s):  
Daniil Nikitin ◽  
Dmitry Penzar ◽  
Andrew Garazha ◽  
Maxim Sorokin ◽  
Victor Tkachev ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Molecular Pathways ◽  
Transcription Factor Proteins

Oxidation of Zinc-Binding Cysteine Residues in Transcription Factor Proteins

2001 ◽  
Vol 3 (4) ◽  
pp. 549-564 ◽  
Author(s):  
Dean E. Wilcox ◽  
Austin D. Schenk ◽  
Brian M. Feldman ◽  
Yin Xu
Keyword(s):  
Transcription Factor ◽  
Zinc Binding ◽  
Cysteine Residues ◽  
Transcription Factor Proteins
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