Absolute Configuration Determination of a Taxol Precursor Based on Raman Optical Activity Spectra

2017 ◽  
Vol 121 (7) ◽  
pp. 1544-1551 ◽  
Author(s):  
Václav Profant ◽  
Alexandr Jegorov ◽  
Petr Bouř ◽  
Vladimír Baumruk
Keyword(s):  
Optical Activity ◽  
Absolute Configuration ◽  
Raman Optical Activity

scholarly journals Determination of the Absolute Stereochemistry of Limonene and α-Santalol by Raman Optical Activity Spectroscopy

2012 ◽  
Vol 7 (4) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Akira Sakamoto ◽  
Nao Ohya ◽  
Toshio Hasegawa ◽  
Hiroaki Izumi ◽  
Nakako Tokita ◽  
...  
Keyword(s):  
Organic Compounds ◽  
Optical Activity ◽  
Absolute Configuration ◽  
Natural Compounds ◽  
Vibrational Circular Dichroism ◽  
Raman Optical Activity ◽  
The Absolute ◽  
Circular Dichroïsm ◽  
Absolute Stereochemistry

Determining the absolute stereochemistry of organic compounds in solution remains a challenge. We investigated the use of Raman optical activity (ROA) spectroscopy to address this problem. The absolute configurations of (+)-( R)- and (-)-( S)-limonene were determined by ROA spectroscopy, which can be applied to smaller amounts of sample as compared with vibrational circular dichroism (VCD) spectroscopy. This ROA method was also applied to (+)-( E)-α-santalol and shown to be successful in the determination of the absolute configuration of this compound. ROA spectroscopy shows promise as a useful tool for determining the absolute stereochemistry of many natural compounds.

Determination of absolute configurations from vibrational raman optical activity: Trans-2,3-dimethylthiirane

Talanta ◽  
1993 ◽  
Vol 40 (4) ◽  
pp. 545-549 ◽  
Author(s):  
Prasad L. Polavarapu ◽  
Simeon T. Pickard ◽  
Howard E. Smith ◽  
Thomas M. Black ◽  
Laurence D. Barron ◽  
...  
Keyword(s):  
Optical Activity ◽  
Raman Optical Activity

Absolute Configuration of Bromochlorofluoromethane from Experimental and Ab Initio Theoretical Vibrational Raman Optical Activity

1997 ◽  
Vol 36 (8) ◽  
pp. 885-887 ◽  
Author(s):  
Jeanne Costante ◽  
Lutz Hecht ◽  
Prasad L. Polavarapu ◽  
André Collet ◽  
Laurence D. Barron
Keyword(s):  
Ab Initio ◽  
Optical Activity ◽  
Absolute Configuration ◽  
Raman Optical Activity

Theoretical Determination of the Vibrational Raman Optical Activity Signatures of Helical Polypropylene Chains

ChemPhysChem ◽  
2006 ◽  
Vol 7 (11) ◽  
pp. 2366-2376 ◽  
Author(s):  
Ewa Lamparska ◽  
Vincent Liégeois ◽  
Olivier Quinet ◽  
Benoît Champagne
Keyword(s):  
Optical Activity ◽  
Theoretical Determination ◽  
Raman Optical Activity
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