Interactions between Oppositely Charged Polyelectrolytes by Isothermal Titration Calorimetry: Effect of Ionic Strength and Charge Density

2017 ◽  
Vol 121 (12) ◽  
pp. 2684-2694 ◽  
Author(s):  
Feriel Meriem Lounis ◽  
Joseph Chamieh ◽  
Laurent Leclercq ◽  
Philippe Gonzalez ◽  
Amine Geneste ◽  
...  
Keyword(s):  
Ionic Strength ◽  
Charge Density ◽  
Isothermal Titration Calorimetry ◽  
Titration Calorimetry ◽  
Oppositely Charged

scholarly journals Hyaluronan-Arginine Interactions—An Ultrasound and ITC Study

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2069
Author(s):  
Adam Jugl ◽  
Miloslav Pekař
Keyword(s):  
Molecular Weight ◽  
Ionic Strength ◽  
High Resolution ◽  
Isothermal Titration Calorimetry ◽  
High Ionic Strength ◽  
Point Of View ◽  
Random Coil ◽  
Titration Calorimetry

High-resolution ultrasound spectroscopy and isothermal titration calorimetry were used to characterize interactions between hyaluronan and arginine oligomers. The molecular weight of arginine oligomer plays an important role in interactions with hyaluronan. Interactions were observable for arginine oligomers with eight monomer units and longer chains. The effect of the ionic strength and molecular weight of hyaluronan on interactions was tested. In an environment with increased ionic strength, the length of the arginine oligomer was crucial. Generally, sufficiently high ionic strength suppresses interactions between hyaluronan and arginine oligomers, which demonstrated interactions in water. From the point of view of the molecular weight of hyaluronan, the transition between the rod conformation and the random coil conformation appeared to be important.

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