Empirical Valence Bond Simulations of the Hydride-Transfer Step in the Monoamine Oxidase A Catalyzed Metabolism of Noradrenaline

2016 ◽  
Vol 120 (44) ◽  
pp. 11419-11427 ◽  
Author(s):  
Matic Poberžnik ◽  
Miha Purg ◽  
Matej Repič ◽  
Janez Mavri ◽  
Robert Vianello
Keyword(s):  
Monoamine Oxidase ◽  
Valence Bond ◽  
Hydride Transfer ◽  
Monoamine Oxidase A ◽  
Empirical Valence Bond ◽  
Transfer Step ◽  
Metabolism Of Noradrenaline

scholarly journals Empirical valence bond simulations of the hydride transfer step in the monoamine oxidase B catalyzed metabolism of dopamine

2014 ◽  
Vol 82 (12) ◽  
pp. 3347-3355 ◽  
Author(s):  
Matej Repič ◽  
Robert Vianello ◽  
Miha Purg ◽  
Fernanda Duarte ◽  
Paul Bauer ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Valence Bond ◽  
Hydride Transfer ◽  
Monoamine Oxidase B ◽  
Empirical Valence Bond ◽  
Transfer Step

scholarly journals How Monoamine Oxidase A Decomposes Serotonin: An Empirical Valence Bond Simulation of the Reactive Step

2020 ◽  
Vol 124 (38) ◽  
pp. 8259-8265
Author(s):  
Alja Prah ◽  
Miha Purg ◽  
Jernej Stare ◽  
Robert Vianello ◽  
Janez Mavri
Keyword(s):  
Monoamine Oxidase ◽  
Valence Bond ◽  
Monoamine Oxidase A ◽  
Empirical Valence Bond

scholarly journals Empirical Valence Bond Simulations Suggest a Direct Hydride Transfer Mechanism for Human Diamine Oxidase

ACS Omega ◽  
2018 ◽  
Vol 3 (4) ◽  
pp. 3665-3674 ◽  
Author(s):  
Aleksandra Maršavelski ◽  
Dušan Petrović ◽  
Paul Bauer ◽  
Robert Vianello ◽  
Shina Caroline Lynn Kamerlin
Keyword(s):  
Diamine Oxidase ◽  
Valence Bond ◽  
Hydride Transfer ◽  
Transfer Mechanism ◽  
Empirical Valence Bond ◽  
Human Diamine Oxidase

scholarly journals High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: a preliminary report

2021 ◽  
pp. 105381
Author(s):  
Georg S. Kranz ◽  
Marie Spies ◽  
Chrysoula Vraka ◽  
Ulrike Kaufmann ◽  
Eva-Maria Klebermass ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Human Brain ◽  
Preliminary Report ◽  
Monoamine Oxidase A ◽  
High Dose ◽  
Testosterone Treatment

Monoamine Oxidase A (MAOA) methylation in acrophobia: an epigenetic correlate of therapy response?

2019 ◽  
Vol 29 ◽  
pp. S203-S204
Author(s):  
M. Schiele ◽  
C. Ziegler ◽  
L. Kollert ◽  
A. Katzorke ◽  
D. Gromer ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Therapy Response ◽  
Monoamine Oxidase A

scholarly journals Association between monoamine oxidase A promoter polymorphism and the risk of sudden infant death syndrome: a meta-analysis

2021 ◽  
Author(s):  
Qiaoxia Zhou ◽  
Daoyin Gong ◽  
Yu Zhang ◽  
Feijun Huang
Keyword(s):  
Monoamine Oxidase ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Protective Factor ◽  
Meta Analysis ◽  
Variable Number Tandem Repeat ◽  
Sudden Infant Death ◽  
Monoamine Oxidase A ◽  
Sudden Infant ◽  
Increased Risk

Abstract Introduction The etiology of sudden infant death syndrome (SIDS) remains an unsolved problem. The aim of this meta-analysis is to investigate the potential association between monoamine oxidase A (MAOA) promoter variable number tandem repeat (VNTR) polymorphism and SIDS risk. Methods A systematic review and meta-analysis were conducted on studies from accessible electronic databases. Each VNTR variant was examined in each gender independently by comparing with the pooled results of other alleles. Results A total of six independent case–control studies including 1022 SIDS cases and 1839 controls were enrolled in this meta-analysis. In both of the whole populations and Caucasian populations, male infants with the low-MAOA-expression alleles (2R+3R) were found to exhibit a statistically significant increased risk of SIDS, whereas those with a 4R allele exhibited a reduced risk of SIDS. Besides, an increased risk of SIDS was detected in male Caucasian infants with 2R or 3R alleles. However, none of the allele or genotype variants was associated with SIDS in female victims. Conclusion In male Caucasian infants, the low expression of MAOA promoter VNTR alleles (2R and 3R) is associated with an increased risk of SIDS, and the existence of the 4R allele could be regarded as a protective factor.

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