Preformed Seeds Modulate Native Insulin Aggregation Kinetics

2015 ◽  
Vol 119 (49) ◽  
pp. 15089-15099 ◽  
Author(s):  
Colina Dutta ◽  
Mu Yang ◽  
Fei Long ◽  
Reza Shahbazian-Yassar ◽  
Ashutosh Tiwari
Keyword(s):  
Aggregation Kinetics ◽  
Native Insulin

Functional Fractionation of Platelets: Aggregation Kinetics and Glycoprotein Labeling of Differing Platelet Populations

1982 ◽  
Vol 48 (02) ◽  
pp. 211-216 ◽  
Author(s):  
V M Haver ◽  
A R L Gear
Keyword(s):  
Galactose Oxidase ◽  
Aggregation Kinetics ◽  
Maximal Rate ◽  
Membrane Glycoproteins ◽  
Whole Cells ◽  
Reversible Aggregation ◽  
Significant Difference ◽  
Small Doses ◽  
Major Loss ◽  
Kinetics Of

SummaryPlatelet heterogeneity has been studied with a technique called functional fractionation which employs gentle centrifugation to yield subpopulations (“reactive” and “less-reactive” platelets) after exposure to small doses of aggregating agent. Aggregation kinetics of the different platelet populations were investigated by quenched-flow aggregometry. The large, “reactive” platelets were more sensitive to ADP (Ka = 1.74 μM) than the smaller “less-reactive” platelets (Ka = 4.08 μM). However, their maximal rate of aggregation (Vmax, % of platelets aggregating per sec) of 23.3 was significantly lower than the “less-reactive” platelets (Vmax = 34.7). The “reactive” platelets had a 2.2 fold higher level of cyclic AMP.Platelet glycoproteins were labeled using the neuraminidase-galactose oxidase – [H3]-NaBH4 technique. When platelets were labeled after reversible aggregation, the “reactive” platelets showed a two-fold decrease in labeling efficiency (versus control platelets). However, examination of whole cells or membrane preparations from reversibly aggregated platelets revealed no significant difference in Coomassie or PAS (Schiff) staining.These results suggest that the large, “reactive” platelets are more sensitive to ADP but are not hyperaggregable in a kinetic sense. Reversible aggregation may cause a re-orientation of membrane glycoproteins that is apparently not characterized by a major loss of glycoprotein material.

scholarly journals Shear-induced reaction-limited aggregation kinetics of Brownian particles at arbitrary concentrations

2010 ◽  
Vol 132 (13) ◽  
pp. 134903 ◽  
Author(s):  
Alessio Zaccone ◽  
Daniele Gentili ◽  
Massimo Morbidelli
Keyword(s):  
Aggregation Kinetics ◽  
Brownian Particles ◽  
Kinetics Of ◽  
Induced Reaction

scholarly journals Rheological behaviour and aggregation kinetics of EG/water based MCNT nano-suspension for sub-zero temperature cold storage

2019 ◽  
Vol 158 ◽  
pp. 4846-4851
Author(s):  
Yaoting Huang ◽  
Chunping Xie ◽  
Chuan Li ◽  
Yongliang Li ◽  
Yulong Ding
Keyword(s):  
Cold Storage ◽  
Rheological Behaviour ◽  
Aggregation Kinetics ◽  
Zero Temperature ◽  
Water Based ◽  
Kinetics Of

Geometry and the exchange principle in cell aggregation kinetics

1973 ◽  
Vol 41 (1) ◽  
pp. 1-21 ◽  
Author(s):  
P.L. Antonelli ◽  
T.D. Rogers ◽  
M.A. Willard
Keyword(s):  
Cell Aggregation ◽  
Aggregation Kinetics ◽  
Exchange Principle

The impact of stabilization mechanism on the aggregation kinetics of silver nanoparticles

2012 ◽  
Vol 429 ◽  
pp. 325-331 ◽  
Author(s):  
Amro M. El Badawy ◽  
Kirk G. Scheckel ◽  
Makram Suidan ◽  
Thabet Tolaymat
Keyword(s):  
Silver Nanoparticles ◽  
Aggregation Kinetics ◽  
Stabilization Mechanism ◽  
The Impact ◽  
Kinetics Of

scholarly journals A pH-Induced Switch in Human Glucagon-like Peptide-1 Aggregation Kinetics

2016 ◽  
Vol 138 (50) ◽  
pp. 16259-16265 ◽  
Author(s):  
Karolina L. Zapadka ◽  
Frederik J. Becher ◽  
Shahid Uddin ◽  
Paul G. Varley ◽  
Steve Bishop ◽  
...  
Keyword(s):  
Aggregation Kinetics ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals The Conformation and the Aggregation Kinetics of α-Synuclein Depend on the Proline Residues in Its C-Terminal Region

Biochemistry ◽  
2010 ◽  
Vol 49 (43) ◽  
pp. 9345-9352 ◽  
Author(s):  
Jessika Meuvis ◽  
Melanie Gerard ◽  
Linda Desender ◽  
Veerle Baekelandt ◽  
Yves Engelborghs
Keyword(s):  
Terminal Region ◽  
Aggregation Kinetics ◽  
Kinetics Of

Effect of ionic strength on the aggregation kinetics of the amidated amyloid beta peptide Aβ (1-40) in aqueous solutions

2017 ◽  
Vol 228 ◽  
pp. 98-107 ◽  
Author(s):  
Adriana Campos-Ramírez ◽  
Maripaz Márquez ◽  
Liliana Quintanar ◽  
Luis F. Rojas-Ochoa
Keyword(s):  
Ionic Strength ◽  
Aqueous Solutions ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Aggregation Kinetics ◽  
Beta Peptide ◽  
Kinetics Of

A Particle Dynamic Model of Red Blood Cell Aggregation Kinetics

2009 ◽  
Vol 37 (11) ◽  
pp. 2299-2309 ◽  
Author(s):  
Marianne Fenech ◽  
Damien Garcia ◽  
Herbert J. Meiselman ◽  
Guy Cloutier
Keyword(s):  
Blood Cell ◽  
Dynamic Model ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Aggregation Kinetics ◽  
Particle Dynamic ◽  
Red Blood Cell Aggregation ◽  
Blood Cell Aggregation
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