Physicochemical Characterization of 2-Hydroxybenzophenone with β-Cyclodextrin in Solution and Solid State

2015 ◽  
Vol 119 (18) ◽  
pp. 5918-5925 ◽  
Author(s):  
Matias I. Sancho ◽  
Marcos G. Russo ◽  
M. Sergio Moreno ◽  
Estela Gasull ◽  
Sonia E. Blanco ◽  
...  
Keyword(s):  
Solid State ◽  
Physicochemical Characterization

scholarly journals Extraction and Physicochemical Characterization of Chitin Derived from the Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae)

2019 ◽  
Author(s):  
Xesús Feás ◽  
M. Pilar Vázquez-Tato ◽  
Julio A. Seijas Vázquez ◽  
Francisco Fraga-López
Keyword(s):  
Solid State ◽  
Model Fitting ◽  
Physicochemical Characterization ◽  
Frequency Factor ◽  
Alternative Source ◽  
Promising Alternative ◽  
Vespa Velutina ◽  
Model Free ◽  
Isolation And Characterization

The isolation and characterization of chitin (CHI) obtained from Vespa velutina (CHIVV) is described. Moreover, a trapping procedure is presented to selectively catch the invasive species. The chitin contents of dry Vespa velutina was observed to be 11.7 %. The physicochemical properties of CHIVV was characterized by Fourier transform infrared spectroscopy (FTIR), solid-state NMR (ssNMR), elemental analysis (EA), scanning electron microscopy (SEM) and thermogravimetric analysis (TG). Obtained CHIVV is close to pure (43, 47% C, 6.94% H, and 6.85% N) and full acetylated with a value of 95.44%. Also, lifetime and kinetic parameters such as activation E and the frequency factor A using model-free and model-fitting methods, were determined. For CHIVV the solid state mechanism that follows the thermodegradation is of type F2 (Random nucleation around two nuclei). Vespa velutina chitin should not be used at temperatures above 60ºC, since its half-life would be only one year, and from an industrial point of view it would not be profitable. Based on certain factors such as the current and probable continued abundance of Vespa velutina and the quality of the product obtained, the invasive Asian hornet is a promising alternative source of chitin.

scholarly journals Physicochemical Characterization of NPC 1161C, A Novel Antimalarial 8-Aminoquinoline, in Solution and Solid State

2010 ◽  
Vol 12 (1) ◽  
pp. 177-191 ◽  
Author(s):  
Asish Kumar Dutta ◽  
Steven P. Stodghill ◽  
Christy M. Wyandt
Keyword(s):  
Solid State ◽  
Physicochemical Characterization ◽  
Npc 1161C

Physicochemical Characterization of Rice Straw Pretreated with Sodium Hydroxide in the Solid State for Enhancing Biogas Production

2008 ◽  
Vol 22 (4) ◽  
pp. 2775-2781 ◽  
Author(s):  
Yanfeng He ◽  
Yunzhi Pang ◽  
Yanping Liu ◽  
Xiujin Li ◽  
Kuisheng Wang
Keyword(s):  
Solid State ◽  
Sodium Hydroxide ◽  
Rice Straw ◽  
Biogas Production ◽  
Physicochemical Characterization

Physicochemical characterization of dapagliflozin and its solid-state behavior in stress stability test

2021 ◽  
pp. 1-32
Author(s):  
Dong-Won Oh ◽  
Jinmann Chon ◽  
Ji-Hyun Kang ◽  
Chang-Soo Han ◽  
Dae Hwan Shin ◽  
...  
Keyword(s):  
Solid State ◽  
Physicochemical Characterization ◽  
Stability Test ◽  
State Behavior

Physicochemical Characterization of Interaction of Ibuprofen by Solid-State Milling with Aluminum Hydroxide

2008 ◽  
Vol 34 (7) ◽  
pp. 726-734 ◽  
Author(s):  
Subrata Mallick ◽  
Satyanarayan Pattnaik ◽  
Kalpana Swain ◽  
Pintu K. De ◽  
Arindam Saha ◽  
...  
Keyword(s):  
Solid State ◽  
Aluminum Hydroxide ◽  
Physicochemical Characterization

scholarly journals Solid-State Characterization of Different Crystalline Forms of Sitagliptin

Materials ◽  
2019 ◽  
Vol 12 (15) ◽  
pp. 2351 ◽  
Author(s):  
Nayana C. F. Stofella ◽  
Andressa Veiga ◽  
Laiane J. Oliveira ◽  
Elisa F. Montin ◽  
Itamar F. Andreazza ◽  
...  
Keyword(s):  
Solid State ◽  
Melting Point ◽  
Physicochemical Characterization ◽  
Spectroscopic Techniques ◽  
Scanning Calorimetry ◽  
Pharmaceutical Dosage Form ◽  
Base Form ◽  
Crystalline Forms ◽  
Solid State Characterization

Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-4, used for the treatment of type 2 diabetes mellitus. The crystal structure of active pharmaceutical solids determines their physical and chemical properties. The polymorphism, solvates and hydrates can influence the free energy, thermodynamic parameters, solubility, solid-state stability, processability and dissolution rate, besides directly affecting the bioavailability. Thus, the physicochemical characterization of an active pharmaceutical ingredient is required to guarantee the rational development of new dosage forms. In this context, we describe herein the solid-state characterization of three crystalline forms of sitagliptin: sitagliptin phosphate monohydrate, sitagliptin phosphate anhydrous and sitagliptin base form. The investigation was carried out using differential scanning calorimetry (DSC), thermogravimetry (TG)/derivative thermogravimetry (DTG), spectroscopic techniques, X-ray powder diffraction (XRPD) and morphological analysis by scanning electron microscopy. The thermal analysis revealed that during the dehydration of sitagliptin phosphate monohydrate (Tpeak = 134.43 °C, ΔH = −1.15 J g−1) there is a characteristic crystalline transition event, which alters the physicochemical parameters of the drug, such as the melting point and solubility. The crystalline behavior of sitagliptin base form differs from that of sitagliptin phosphate monohydrate and sitagliptin phosphate anhydrous, mainly with regard to the lower temperature of the fusion event. The melting point (Tpeak) values obtained were 120.29 °C for sitagliptin base form, 206.37 °C for sitagliptin phosphate monohydrate and 214.92 °C for sitagliptin phosphate anhydrous. In relation to the thermal stability, sitagliptin phosphate monohydrate and sitagliptin phosphate anhydrous showed a slight difference; however, both are more thermostable than the base molecule. Therefore, through this study it was possible to establish the most suitable crystalline form of sitagliptin for the development of a safe, effective and appropriate pharmaceutical dosage form.

scholarly journals Extraction and Physicochemical Characterization of Chitin Derived from the Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae)

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 384 ◽  
Author(s):  
Xesús Feás ◽  
M. Pilar Vázquez-Tato ◽  
Julio A. Seijas ◽  
Anna Pratima G. Nikalje ◽  
Francisco Fraga-López
Keyword(s):  
Solid State ◽  
Model Fitting ◽  
Physicochemical Characterization ◽  
Frequency Factor ◽  
Alternative Source ◽  
Promising Alternative ◽  
Vespa Velutina ◽  
Model Free ◽  
Isolation And Characterization

Fifteen years ago, at least one multimated female yellow-legged Asian hornet (Vespa velutina Lepeletier 1836) arrived in France, which gave rise to a pan-European invasion. In this study, the isolation and characterization of chitin (CHI) that was obtained from Vespa velutina (CHIVV) is described. In addition, an easy procedure is carried out to capture the raw insect, selectively and with high rates of success. The chitin contents of dry VV was observed to be 11.7%. Fourier transform infrared spectroscopy (FTIR), solid-state NMR (ssNMR), elemental analysis (EA), scanning electron microscopy (SEM), and thermogravimetric analysis (TG) characterized the physicochemical properties of CHIVV. The obtained CHIVV is close to pure (43.47% C, 6.94% H, and 6.85% N), and full acetylated with a value of 95.44%. Additionally, lifetime and kinetic parameters such as activation E and the frequency factor A using model-free and model-fitting methods, were determined. For CHIVV the solid state mechanism that follows the thermodegradation is of type F2 (random nucleation around two nuclei). The invasive Asian hornet is a promising alternative source of CHI, based on certain factors, such as the current and probable continued abundance of the quantity and quality of the product obtained.

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