Human Telomeric RNA G-Quadruplex Response to Point Mutation in the G-Quartets

2015 ◽  
Vol 119 (13) ◽  
pp. 4617-4627 ◽  
Author(s):  
Prachi Agarwala ◽  
Santosh Kumar ◽  
Satyaprakash Pandey ◽  
Souvik Maiti
Keyword(s):  
Point Mutation ◽  
G Quadruplex ◽  
Telomeric Rna

scholarly journals Electrospray Mass Spectrometry of Telomeric RNA (TERRA) Reveals the Formation of Stable Multimeric G-Quadruplex Structures

2010 ◽  
Vol 132 (27) ◽  
pp. 9328-9334 ◽  
Author(s):  
Gavin W. Collie ◽  
Gary N. Parkinson ◽  
Stephen Neidle ◽  
Frédéric Rosu ◽  
Edwin De Pauw ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
G Quadruplex ◽  
Telomeric Rna

Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K+ Solution

Biochemistry ◽  
2013 ◽  
Vol 52 (13) ◽  
pp. 2176-2183 ◽  
Author(s):  
Herry Martadinata ◽  
Anh Tuân Phan
Keyword(s):  
G Quadruplex ◽  
Telomeric Rna

A U-Tetrad Stabilizes Human Telomeric RNA G-Quadruplex Structure

2010 ◽  
Vol 132 (21) ◽  
pp. 7231-7233 ◽  
Author(s):  
Yan Xu ◽  
Takumi Ishizuka ◽  
Takashi Kimura ◽  
Makoto Komiyama
Keyword(s):  
Quadruplex Structure ◽  
G Quadruplex ◽  
Telomeric Rna

Single-Stranded Condensation Stochastically Blocks G-Quadruplex Assembly in Human Telomeric RNA

2018 ◽  
Vol 9 (10) ◽  
pp. 2498-2503
Author(s):  
Irene Gutiérrez ◽  
Miguel Garavís ◽  
Sara de Lorenzo ◽  
Alfredo Villasante ◽  
Carlos González ◽  
...  
Keyword(s):  
G Quadruplex ◽  
Telomeric Rna

scholarly journals Human Telomeric RNA in G-quadruplex Structure

2008 ◽  
Vol 52 (1) ◽  
pp. 175-176 ◽  
Author(s):  
Y. Xu ◽  
K. Kaminaga ◽  
M. Komiyama
Keyword(s):  
Quadruplex Structure ◽  
G Quadruplex ◽  
Telomeric Rna

Specific G-quadruplex structure recognition of human telomeric RNA over DNA by a fluorescently activated hyperporphyrin

The Analyst ◽  
2015 ◽  
Vol 140 (15) ◽  
pp. 5169-5175 ◽  
Author(s):  
Ying Wang ◽  
Yuehua Hu ◽  
Tao Wu ◽  
Hua Liu ◽  
Lihua Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Selective Recognition ◽  
Quadruplex Structure ◽  
Structure Recognition ◽  
G Quadruplex ◽  
Telomeric Rna

Selective recognition of the G-quadruplex structure of human telomeric RNA (TERRA) over DNA was achieved using an activated hyperporphyrin as a fluorescent probe.

Preferential Binding of π-Ligand Porphyrin Targeting 5′-5′ Stacking Interface of Human Telomeric RNA G-Quadruplex Dimer

2019 ◽  
Vol 10 (9) ◽  
pp. 2143-2150 ◽  
Author(s):  
Qige Qi ◽  
Chunfan Yang ◽  
Ye Xia ◽  
Shaoshi Guo ◽  
Di Song ◽  
...  
Keyword(s):  
G Quadruplex ◽  
Preferential Binding ◽  
Telomeric Rna

Structural switch from a multistranded G-quadruplex to single strands as a consequence of point mutation in the promoter of the human GRIN1 gene

2017 ◽  
Vol 13 (9) ◽  
pp. 1805-1816 ◽  
Author(s):  
Swati Chaudhary ◽  
Mahima Kaushik ◽  
Ritushree Kukreti ◽  
Shrikant Kukreti
Keyword(s):  
Point Mutation ◽  
G Quadruplex

Formation of a multistranded G-quadruplex in a sequence with point mutation in the promoter of the humanGRIN1gene associated with schizophrenia.

Paris I Dysfibrinogenemia: A Point Mutation in Intron 8 Results in Insertion of a 15 Amino Acid Sequence in the Fibrinogen γ-Chain

1993 ◽  
Vol 69 (03) ◽  
pp. 217-220 ◽  
Author(s):  
Jonathan B Rosenberg ◽  
Peter J Newman ◽  
Michael W Mosesson ◽  
Marie-Claude Guillin ◽  
David L Amrani
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Point Mutation ◽  
Genomic Dna ◽  
Comparative Sequence Analysis ◽  
Chain Gene ◽  
Molecular Defect ◽  
Nucleotide Position ◽  
Normal Individuals ◽  
Polymerase Chain

SummaryParis I dysfibrinogenemia results in the production of a fibrinogen molecule containing a functionally abnormal γ-chain. We determined the basis of the molecular defect using polymerase chain reaction (PCR) to amplify the γ-chain region of the Paris I subject’s genomic DNA. Comparative sequence analysis of cloned PCR segments of normal and Paris I genomic DNA revealed only an A→G point mutation occurring at nucleotide position 6588 within intron 8 of the Paris I γ-chain gene. We examined six normal individuals and found only normal sequence in this region, indicating that this change is not likely to represent a normal polymorphism. This nucleotide change leads to a 45 bp fragment being inserted between exons 8 and 9 in the mature γparis I chain mRNA, and encodes a 15 amino acid insert after γ350 [M-C-G-E-A-L-P-M-L-K-D-P-C-Y]. Alternative splicing of this region from intron 8 into the mature Paris I γ-chain mRNA also results after translation into a substitution of S for G at position γ351. Biochemical studies of 14C-iodoacetamide incorporation into disulfide-reduced Paris I and normal fibrinogen corroborated the molecular biologic predictions that two additional cysteine residues exist within the γpariS I chain. We conclude that the insertion of this amino acid sequence leads to a conformationallyaltered, and dysfunctional γ-chain in Paris I fibrinogen.

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