Correction to “Prolific Polymorph Generator ROY in Its Liquid and Glass: Two Conformational Populations Mirroring the Crystalline-State Distribution”

AbstractWe report a new method of Thin Crystal Film deposition. In the present paper we describe the method of crystallization, structure, and optical properties of Bisbenzimidazo[2,1-a:1',2',b']anthra[2,1,9-def:6,5,10-d'e'f']-diisoquinoline-6,9-dion (mixture with cis-isomer) (abbreviated DBI PTCA) sulfonation product. The Thin Crystal Film has a thickness of 200-1000 nm, with anisotropic optical properties such as refraction and absorption indices. X-ray diffraction data evidences a lyotropic liquid crystalline state in liquid phase and crystalline state in solid film. Anisotropic optical properties of the film make it useful in optical devices, e.g. liquid crystal displays.

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Faculty Opinions recommendation of Detailed assessment of X-ray induced structural perturbation in a crystalline state protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1355994.827097 ◽

2010 ◽

Author(s):

James Penner-Hahn

Keyword(s):

Crystalline State ◽

X Ray ◽

Structural Perturbation ◽

Detailed Assessment

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Kinetic analysis of mechanism of intestinal Na+-dependent sugar transport

AJP Cell Physiology ◽

10.1152/ajpcell.1985.248.5.c498 ◽

1985 ◽

Vol 248 (5) ◽

pp. C498-C509 ◽

Cited By ~ 23

Author(s):

D. Restrepo ◽

G. A. Kimmich

Keyword(s):

Experimental Data ◽

Steady State ◽

Sugar Transport ◽

Enzyme Kinetic ◽

Steady State Distribution ◽

State Distribution ◽

Least Squares Fit ◽

Coupling Stoichiometry ◽

Rate Limiting ◽

Kinetics Of

Zero-trans kinetics of Na+-sugar cotransport were investigated. Sugar influx was measured at various sodium and sugar concentrations in K+-loaded cells treated with rotenone and valinomycin. Sugar influx follows Michaelis-Menten kinetics as a function of sugar concentration but not as a function of Na+ concentration. Nine models with 1:1 or 2:1 sodium:sugar stoichiometry were considered. The flux equations for these models were solved assuming steady-state distribution of carrier forms and that translocation across the membrane is rate limiting. Classical enzyme kinetic methods and a least-squares fit of flux equations to the experimental data were used to assess the fit of the different models. Four models can be discarded on this basis. Of the remaining models, we discard two on the basis of the trans sodium dependence and the coupling stoichiometry [G. A. Kimmich and J. Randles, Am. J. Physiol. 247 (Cell Physiol. 16): C74-C82, 1984]. The remaining models are terter ordered mechanisms with sodium debinding first at the trans side. If transfer across the membrane is rate limiting, the binding order can be determined to be sodium:sugar:sodium.

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Charge state distribution of 16O from the 4He(12C,16O)γ reaction of astrophysical interest studied both experimentally and theoretically

Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms ◽

10.1016/j.nimb.2014.02.115 ◽

2014 ◽

Vol 328 ◽

pp. 14-19 ◽

Cited By ~ 2

Author(s):

Shengjin Liu ◽

Makoto Sakurai ◽

Kenshi Sagara ◽

Takashi Teranishi ◽

Kunihiro Fujita ◽

...

Keyword(s):

Charge State ◽

Charge State Distribution ◽

State Distribution ◽

Astrophysical Interest

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The Evolution of Networks and Local Public Good Provision: A Potential Approach

Games ◽

10.3390/g12030055 ◽

2021 ◽

Vol 12 (3) ◽

pp. 55

Author(s):

Markus Kinateder ◽

Luca Paolo Merlino

Keyword(s):

Public Good ◽

Nash Equilibria ◽

Potential Game ◽

Public Good Provision ◽

Local Public Good ◽

Steady State Distribution ◽

State Distribution ◽

Long Run ◽

Split Graphs ◽

Good Provision

In this paper, we propose a game in which each player decides with whom to establish a costly connection and how much local public good is provided when benefits are shared among neighbors. We show that, when agents are homogeneous, Nash equilibrium networks are nested split graphs. Additionally, we show that the game is a potential game, even when we introduce heterogeneity along several dimensions. Using this result, we introduce stochastic best reply dynamics and show that this admits a unique and stationary steady state distribution expressed in terms of the potential function of the game. Hence, even if the set of Nash equilibria is potentially very large, the long run predictions are sharp.

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Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel

Molecules ◽

10.3390/molecules26154481 ◽

2021 ◽

Vol 26 (15) ◽

pp. 4481

Author(s):

Meng Cheng ◽

Qiaoming Liu ◽

Tiantian Gan ◽

Yuanying Fang ◽

Pengfei Yue ◽

...

Keyword(s):

Thin Film ◽

Retention Time ◽

Blood Circulation ◽

Crystalline State ◽

Circulation System ◽

Particle Sizes ◽

High Pressure Homogenization ◽

Rapid Dissolution ◽

Efficient Route

Prolonging in vivo circulation has proved to be an efficient route for enhancing the therapeutic effect of rapidly metabolized drugs. In this study, we aimed to construct a nanocrystal-loaded micelles delivery system to enhance the blood circulation of docetaxel (DOC). We employed high-pressure homogenization to prepare docetaxel nanocrystals (DOC(Nc)), and then produced docetaxel nanocrystal-loaded micelles (DOC(Nc)@mPEG-PLA) by a thin-film hydration method. The particle sizes of optimized DOC(Nc), docetaxel micelles (DOC@mPEG-PLA), and DOC(Nc)@mPEG-PLA were 168.4, 36.3, and 72.5 nm, respectively. The crystallinity of docetaxel was decreased after transforming it into nanocrystals, and the crystalline state of docetaxel in micelles was amorphous. The constructed DOC(Nc)@mPEG-PLA showed good stability as its particle size showed no significant change in 7 days. Despite their rapid dissolution, docetaxel nanocrystals exhibited higher bioavailability. The micelles prolonged the retention time of docetaxel in the circulation system of rats, and DOC(Nc)@mPEG-PLA exhibited the highest retention time and bioavailability. These results reveal that constructing nanocrystal-loaded micelles may be a promising way to enhance the in vivo circulation and bioavailability of rapidly metabolized drugs such as docetaxel.

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