Conformational and Solvation Dynamics of an Amyloidogenic Intrinsically Disordered Domain of a Melanosomal Protein

2022 ◽  
Author(s):  
Priyanka Dogra ◽  
Shruti Arya ◽  
Avinash K. Singh ◽  
Anindya Datta ◽  
Samrat Mukhopadhyay
Keyword(s):  
Solvation Dynamics ◽  
Intrinsically Disordered ◽  
Intrinsically Disordered Domain

scholarly journals One domain fits all: Using disordered regions to sequester misfolded proteins

2018 ◽  
Vol 217 (4) ◽  
pp. 1173-1175 ◽  
Author(s):  
Edgar E. Boczek ◽  
Simon Alberti
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Adenosine Triphosphate ◽  
Small Heat Shock Proteins ◽  
Misfolded Proteins ◽  
Protein Deposition ◽  
Intrinsically Disordered ◽  
Cell Biol ◽  
Shock Proteins ◽  
Intrinsically Disordered Domain

Small heat shock proteins (sHsps) are adenosine triphosphate–independent chaperones that protect cells from misfolded proteins. In this issue, Grousl et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708116) show that the yeast sHsp Hsp42 uses a prion-like intrinsically disordered domain to bind and sequester misfolded proteins in protein deposition sites.

scholarly journals NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B

2017 ◽  
Vol 292 (44) ◽  
pp. 18024-18043 ◽  
Author(s):  
Luiza M. Bessa ◽  
Hélène Launay ◽  
Marie Dujardin ◽  
François-Xavier Cantrelle ◽  
Guy Lippens ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Hepatitis C Virus Rna ◽  
Intrinsically Disordered ◽  
Ns5a Protein ◽  
Virus Rna ◽  
Allosteric Regulator ◽  
Intrinsically Disordered Domain

scholarly journals A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication

2015 ◽  
Vol 290 (31) ◽  
pp. 19104-19120 ◽  
Author(s):  
Marie Dujardin ◽  
Vanesa Madan ◽  
Roland Montserret ◽  
Puneet Ahuja ◽  
Isabelle Huvent ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Replication ◽  
Hepatitis C Virus Rna ◽  
Intrinsically Disordered ◽  
Ns5a Protein ◽  
Virus Rna ◽  
Intrinsically Disordered Domain

PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility

2016 ◽  
Vol 28 (5) ◽  
pp. 401-411 ◽  
Author(s):  
Gayane Machkalyan ◽  
Phan Trieu ◽  
Darlaine Pétrin ◽  
Terence E. Hébert ◽  
Gregory J. Miller
Keyword(s):  
Cell Motility ◽  
Intrinsically Disordered ◽  
Exocyst Complex ◽  
Intrinsically Disordered Domain

scholarly journals Dissociation of the Dimer of the Intrinsically Disordered Domain of RNase Y upon Antibody Binding

2018 ◽  
Vol 115 (11) ◽  
pp. 2102-2113 ◽  
Author(s):  
Pierre Hardouin ◽  
Christophe Velours ◽  
Charles Bou-Nader ◽  
Nadine Assrir ◽  
Soumaya Laalami ◽  
...  
Keyword(s):  
Antibody Binding ◽  
Intrinsically Disordered ◽  
Rnase Y ◽  
Intrinsically Disordered Domain

scholarly journals Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein

Virology ◽  
2019 ◽  
Vol 537 ◽  
pp. 130-142 ◽  
Author(s):  
Peter Agback ◽  
Francisco Dominguez ◽  
Yulia Pustovalova ◽  
Tetyana Lukash ◽  
Nikita Shiliaev ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Chikungunya Virus ◽  
Biological Function ◽  
Intrinsically Disordered ◽  
Intrinsically Disordered Domain
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