Nanotheranostic Probe Built on Methylene Blue Loaded Cucurbituril [8] and Gold Nanorod: Targeted Phototherapy in Combination with SERS Imaging on Breast Cancer Cells

2021 ◽  
Author(s):  
Nisha Narayanan ◽  
Jeong Hee Kim ◽  
Hema Santhakumar ◽  
Manu M. Joseph ◽  
Varsha Karunakaran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Methylene Blue ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Gold Nanorod ◽  
Sers Imaging

scholarly journals Photodynamic effect of Zirconium phosphate biocompatible nano-bilayers containing methylene blue on cancer and normal cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Reza Hosseinzadeh ◽  
Khatereh Khorsandi
Keyword(s):  
Breast Cancer ◽  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Zirconium Phosphate ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Therapy Efficacy

Abstract Pharmaceutical applications of methylene blue, especially as photosensitizer, have been limited due to its rapid enzymatic reduction in the biological systems. In this study nano-platelet zirconium phosphate was synthesized and its biocompatibility was evaluated. The synthesized material was considered as drug delivery vehicle for methylene blue to enhance the photodynamic therapy efficacy in human breast cancer cells. Zirconium phosphate-methylene blue nano-hybrids were characterized by X-Ray Powder Diffraction (XRPD), Scanning Electron Microscopy (SEM), and Thermo gravimetric Analysis (TGA). Biocompatibility of synthesized nano materials were studied on Hu02 human fibroblast normal cell and MDA-MB-231 human breast cancer cell. The results clarified that ZrP-MB nanoparticles could decrease the dark toxicity of free methylene blue. Photodynamic therapy using zirconium phosphate-methylene blue on MDA-MB-231 human breast cancer was evaluated by MTT assay, colony forming ability assay, AO/EB dual staining and flow cytometry detection of apoptosis. The results suggest that zirconium phosphate-methylene blue nano-hybrids significantly enhance photodynamic therapy efficacy probably via apoptosis cell death mechanism against human breast cancer cells. According to the results, zirconium phosphate nanoparticles could be suggested as a promising nano-carrier for photosensitizer delivery in photodynamic therapy.

scholarly journals Small Molecule-Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells

Small ◽  
2012 ◽  
Vol 8 (18) ◽  
pp. 2819-2822 ◽  
Author(s):  
Erik C. Dreaden ◽  
Sandra C. Mwakwari ◽  
Lauren A. Austin ◽  
Matthew J. Kieffer ◽  
Adegboyega K. Oyelere ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Small Molecule ◽  
Breast Cancer Cells ◽  
Gold Nanorod ◽  
Macrophage Cytotoxicity

Inhibiting metastasis of breast cancer cells in vitro using gold nanorod-siRNA delivery system

Nanoscale ◽  
2011 ◽  
Vol 3 (9) ◽  
pp. 3923 ◽  
Author(s):  
Weiqi Zhang ◽  
Jie Meng ◽  
Yinglu Ji ◽  
Xiaojin Li ◽  
Hua Kong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Delivery System ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Gold Nanorod ◽  
Sirna Delivery System

The proliferation of breast cancer cells are inhibited by the human intrabody targeting cyclinD1

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Lei Wang ◽  
Xun Zhou ◽  
Lihong Zhou ◽  
Yong Chen ◽  
Xun Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells
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