Hollow Gold Nanosphere Templated Synthesis of PEGylated Hollow Gold Nanostars and Use for SERS Detection of Amyloid Beta in Solution

2021 ◽  
Author(s):  
A’Lester C. Allen ◽  
Mekedlawit Efrem ◽  
Umadevi Mahalingam ◽  
Melissa Guarino-Hotz ◽  
Alejandro R. Foley ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Templated Synthesis ◽  
Gold Nanostars ◽  
Sers Detection ◽  
Gold Nanosphere

SERS detection of uranyl using functionalized gold nanostars promoted by nanoparticle shape and size

The Analyst ◽  
2016 ◽  
Vol 141 (17) ◽  
pp. 5137-5143 ◽  
Author(s):  
Grace Lu ◽  
Tori Z. Forbes ◽  
Amanda J. Haes
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Nanoparticle Shape ◽  
Gold Nanostars ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Enhanced Raman Scattering ◽  
Shape And Size

Quantitative uranyl detection using surface-enhanced Raman scattering and functionalized gold nanostars.

scholarly journals Magnetite-Supported Gold Nanostars for the Uptake and SERS Detection of Tetracycline

Nanomaterials ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 31 ◽  
Author(s):  
Paula Pinheiro ◽  
Sara Fateixa ◽  
Helena Nogueira ◽  
Tito Trindade
Keyword(s):  
Hybrid Composites ◽  
Gold Nanostars ◽  
Surface Enhanced ◽  
Seed Growth ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Growth Method ◽  
Enhanced Raman Scattering ◽  
Supported Gold

Magnetite nanoparticles (MNPs) decorated with gold nanostars (AuNSs) have been prepared by using a seed growth method without the addition of surfactants or colloidal stabilizers. The hybrid nanomaterials were investigated as adsorbents for the uptake of tetracycline (TC) from aqueous solutions and subsequent detection using surface-enhanced Raman scattering (SERS). Several parameters were investigated in order to optimize the performance of these hybrid platforms on the uptake and SERS detection of TC, including variable pH values and the effect of contact time on the removal of TC. The spatial distribution of TC and AuNS on the hybrid composites was accomplished by coupling SERS analysis with Raman imaging studies, allowing also for the determination of the detection limit for TC when dissolved in ultrapure water (10 nM) and in more complex aqueous matrices (1 μM). Attempts were also made to investigate the adsorption modes of the TC molecules at the surface of the metal NPs by taking into account the enhancement of the Raman bands in these different matrices.

scholarly journals Gold Nanostars Bioconjugation for Selective Targeting and SERS Detection of Biofluids

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 665
Author(s):  
Caterina Dallari ◽  
Claudia Capitini ◽  
Martino Calamai ◽  
Andrea Trabocchi ◽  
Francesco Saverio Pavone ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Biological Fluids ◽  
Neuroblastoma Cells ◽  
Neutralizing Antibody ◽  
Surface Enhanced Raman Spectroscopy ◽  
Detection Techniques ◽  
Gold Nanostars ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Hemagglutinin Protein

Gold nanoparticles (AuNPs) show physicochemical and optical functionalities that are of great interest for spectroscopy-based detection techniques, and especially for surface enhanced Raman spectroscopy (SERS), which is capable of providing detailed information on the molecular content of analysed samples. Moreover, the introduction of different moieties combines the interesting plasmonic properties of the AuNPs with the specific and selective recognition capabilities of the antibodies (Ab) towards antigens. The conjugation of biomolecules to gold nanoparticles (AuNPs) has received considerable attention for analysis of liquid samples and in particular biological fluids (biofluids) in clinical diagnostic and therapeutic field. To date, gold nanostars (AuNSts) are gaining more and more attention as optimal enhancers for SERS signals due to the presence of sharp branches protruding from the core, providing a huge number of “hot spots”. To this end, we focused our attention on the design, optimization, and deep characterization of a bottom up-process for (i) AuNPs increasing stabilization in high ionic strength buffer, (ii) covalent conjugation with antibodies, while (iii) retaining the biofunctionality to specific tag analyte within the biofluids. In this work, a SERS-based substrate was developed for the recognition of a short fragment (HA) of the hemagglutinin protein, which is the major viral antigen inducing a neutralizing antibody response. The activity and specific targeting with high selectivity of the Ab-AuNPs was successfully tested in transfected neuroblastoma cells cultures. Then, SERS capabilities were assessed measuring Raman spectra of HA solution, thus opening interesting perspective for the development of novel versatile highly sensitive biofluids sensors.

scholarly journals Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging

Biomaterials ◽  
2016 ◽  
Vol 106 ◽  
pp. 87-97 ◽  
Author(s):  
Furong Tian ◽  
João Conde ◽  
Chenchen Bao ◽  
Yunsheng Chen ◽  
James Curtin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Ftir Imaging ◽  
Gold Nanostars ◽  
Sers Detection

Plasmonics-active gold nanostars for chemical and biological sensing using SERS detection

2015 ◽  
Author(s):  
Yang Liu ◽  
Hsiangkuo Yuan ◽  
Andrew M. Fales ◽  
Tuan Vo-Dinh
Keyword(s):  
Biological Sensing ◽  
Gold Nanostars ◽  
Sers Detection

Substrate templated synthesis of single-phase and uniform Zr-porphyrin-based metal–organic frameworks

2020 ◽  
Vol 7 (1) ◽  
pp. 221-231
Author(s):  
Seong Won Hong ◽  
Ju Won Paik ◽  
Dongju Seo ◽  
Jae-Min Oh ◽  
Young Kyu Jeong ◽  
...  
Keyword(s):  
Chemical Bath Deposition ◽  
Single Phase ◽  
Metal Organic Frameworks ◽  
Templated Synthesis ◽  
Pore Structures ◽  
Phase Pure ◽  
Metal Organic ◽  
Cbd Method

We successfully demonstrate that the chemical bath deposition (CBD) method is a versatile method for synthesizing phase-pure and uniform MOFs by controlling their nucleation stages and pore structures.

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

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