Exploring the Noncovalent Interactions of the Dinuclear Cu(II) Schiff Base Complex with Bovine Serum Albumin and Cell Viability against the SiHa Cancer Cell Line

2021 ◽  
Author(s):  
Ribhu Maity ◽  
Nayim Sepay ◽  
Ushasi Pramanik ◽  
Kalyanmoy Jana ◽  
Saptarshi Mukherjee ◽  
...  
Keyword(s):  
Schiff Base ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Cell Viability ◽  
Cell Line ◽  
Cancer Cell ◽  
Bovine Serum ◽  
Noncovalent Interactions ◽  
Schiff Base Complex ◽  
Cancer Cell Line

scholarly journals Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation

RSC Advances ◽  
2018 ◽  
Vol 8 (71) ◽  
pp. 40720-40730 ◽  
Author(s):  
Jie Tang ◽  
Pengfei Yao ◽  
Lina Wang ◽  
Hedong Bian ◽  
Meiyi Luo ◽  
...  
Keyword(s):  
Schiff Base ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Schiff Base Complex ◽  
Docking Studies ◽  
Host Protein ◽  
Schiff Base Complexes ◽  
Uv Visible ◽  
Artificial Metalloenzymes

Artificial metalloenzymes have been prepared by non-covalent insertion of transition metal Schiff-base complexes into bovine serum albumin as the host protein and were characterized by UV-visible spectroscopy, ESI-TOF mass spectrometry and molecular docking studies.

scholarly journals Screening and assessment of molecular mechanistic actions of 5-hydroxy-1-methylpiperidin-2-one against free radicals, lung cancer cell line (A549), and binding properties on bovine serum albumin

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sangilimuthu Alagar Yadav ◽  
Lukmanul Hakkim Faruck ◽  
Rajagopal Subramanium ◽  
Lakshmi K. Surendren ◽  
Hamid Bakshi
Keyword(s):  
Lung Cancer ◽  
Bovine Serum Albumin ◽  
Fluorescence Quenching ◽  
Serum Albumin ◽  
Cell Line ◽  
Bovine Serum ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Binding Properties

Abstract Background Natural products play a key role in treating different ailment including diabetes, asthma, skin diseases, and cancer. It is well known that synthetic drugs elicit significant toxicity when used in the clinic. A higher drug affinity towards carrier protein Bovine Serum Albumin (BSA) would enhance a higher drug bioavailability which in turn leads to a higher therapeutic efficacy. The focus of the present study was to investigate antioxidant and anti-cancer potential of 5-hyrdoxy1-methylpiperidin-2-one (5-HMP) isolated from leaves of Tragia involucrata. Methods and material In vitro free radical scavenging assays and MTT assay were employed to assess the antioxidant activity of 5-HMP and cytotoxicity of 5-HMP on lung cancer cell line, A549, respectively. In addition, attempts were made to investigate 5-HMP binding capacity on BSA by spectral studies and molecular docking. Results The antioxidant data revealed that 5-HMP inhibited the radicals with an IC50 value of 49.55 ± 0.75 μg/ml which was comparable with the IC50 values afforded by l-ascorbic acid. 5-HMP exhibited a dose-dependent cytotoxicity on A549 cells with an IC50 value of 30.00 ± 0.55 μg/ml. further 5-HMP induced a cell cycle arrest in A549 at S and G2/M phase. The fluorescence quenching was observed when an increasing concentration of 5-HMP, reacts with a fixed concentration of BSA (1.0 μM). The fluorescence quenching of BSA by 5-HMP indicated a binding constant of K5-HMP = 2.8 ± 1.4 × 104M−1 with corresponding binding free energy (ΔG)−6.06 K.cal/mole. Conclusions This paper concluded that 5-HMP possesses antioxidant properties, cytotoxic effects and also it possesses good drug binding properties on bovine serum albumin.

Bovine serum albumin–cobalt(ii) Schiff base complex hybrid: an efficient artificial metalloenzyme for enantioselective sulfoxidation using hydrogen peroxide

2016 ◽  
Vol 45 (19) ◽  
pp. 8061-8072 ◽  
Author(s):  
Jie Tang ◽  
Fuping Huang ◽  
Yi Wei ◽  
Hedong Bian ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Schiff Base ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Schiff Base Complex ◽  
Base Complex ◽  
Complex Hybrid ◽  
Artificial Metalloenzyme

An artificial metalloenzyme (BSA–CoL) based on the incorporation of a cobalt(ii) Schiff base complex {CoL, H2L = 2,2′-[(1,2-ethanediyl)bis(nitrilopropylidyne)]bisphenol} with bovine serum albumin (BSA) has been synthesized and characterized.

scholarly journals ANTICANCER ACTIVITY OF SILVER NANOPARTICLES AGAINST HUMAN BREAST CANCER CELL LINE

2019 ◽  
Vol 6 (1) ◽  
pp. 25-29
Author(s):  
Dinesh B ◽  
Ranjithkumar R ◽  
Sharmila C ◽  
Selvam K ◽  
Chandar Shekar B
Keyword(s):  
Breast Cancer ◽  
Cell Viability ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Green Technology ◽  
Future Application ◽  
Dose Dependent

The present study demonstrated the effectiveness of bioinspired synthesized AgNPs against MCF-7 breast cancer cell line, we found a dramatic decrease in cell viability when the concentration of the bioinspired synthesized AgNPs was increased and there was a dose-dependent reduction in cell viability. This study further indicates the significance of green technology for nanoparticle fabrication and future application in control of several human diseases.

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