scholarly journals Autofluorescence of Amyloids Determined by Enantiomeric Composition of Peptides

2021 ◽  
Author(s):  
Manuela Grelich-Mucha ◽  
Ana M. Garcia ◽  
Vladimir Torbeev ◽  
Katarzyna Ożga ◽  
Łukasz Berlicki ◽  
...  
Keyword(s):  
Enantiomeric Composition

scholarly journals A useful quantitative model for determination of enantiomeric composition of racemate praziquantel by ultraviolet spectroscopy combined with partial least squares and its application to praziquantel tablets

2018 ◽  
Vol 11 (03) ◽  
pp. 1850011 ◽  
Author(s):  
Man Zhao ◽  
Ran Meng ◽  
Yifang Lu ◽  
Lingyun Hu ◽  
Na Sun ◽  
...  
Keyword(s):  
Root Mean Square Error ◽  
Least Squares ◽  
Partial Least Squares ◽  
Mean Square Error ◽  
Root Mean Square ◽  
Reference Value ◽  
Quantitative Model ◽  
Enantiomeric Composition ◽  
Mean Square ◽  
Validation Set

A simple and novel method has been proposed to determine the enantiomeric composition of racemate praziquantel (PZQ) by using the analysis of ultraviolet (UV) spectroscopy combined with partial least squares (PLS). This method does not rely on the use of expensive carbohydrates such as cyclodextrins, but on the use of inexpensive sucrose, which is equally effective as carbohydrate. PZQ has two enantiomers. Through measuring the slight difference in the UV spectral absorption of PZQ due to different interactions between its two enantiomers and sucrose, the enantiomeric composition was determined by a quantitative model based on PLS analysis. The model showed that the correlation coefficients of calibration set and validation set were 0.9971 and 0.9972, respectively. The root mean square error of calibration (RMSEC) and the root mean square error of prediction (RMSEP) were 0.0167 and 0.0129, respectively. Then, the independent data of PZQ tablets were also used to test how well the quantitative model of PLS predicted the enantiomeric composition. The ratio of S-PZQ in tablet was 0.492, determined by high-performance liquid chromatography as the reference value. Six solutions of the tablet samples were prepared, and the ratios of S-PZQ in tablet samples in the validation set were predicted by the PLS model. Their relative errors with the reference value were not more than 4%. Therefore, the established model could be accurate and employed to predict the enantiomeric compositions of PZQ tablets.

Enantiomeric composition of nornicotine, anatabine, and anabasine in tobacco

Chirality ◽  
1999 ◽  
Vol 11 (1) ◽  
pp. 82-84 ◽  
Author(s):  
Daniel W. Armstrong ◽  
Xiande Wang ◽  
Jauh-Tzuoh Lee ◽  
Yan-Song Liu
Keyword(s):  
Enantiomeric Composition

Enantiomeric composition of lower epoxyalkanes produced by methane-, alkane-, and alkene-utilizing bacteria

1988 ◽  
Vol 10 (4) ◽  
pp. 214-218 ◽  
Author(s):  
C.A.G.M. Weijers ◽  
C.G. van Ginkel ◽  
J.A.M. de Bont
Keyword(s):  
Enantiomeric Composition
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