Differences in the Nature of the Phosphoryl Transfer Transition State in Protein Phosphatase 1 and Alkaline Phosphatase: Insights from QM Cluster Models

Rui Lai; Qiang Cui

doi:10.1021/acs.jpcb.0c07863

Differences in the Nature of the Phosphoryl Transfer Transition State in Protein Phosphatase 1 and Alkaline Phosphatase: Insights from QM Cluster Models

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.0c07863 ◽

2020 ◽

Vol 124 (42) ◽

pp. 9371-9384 ◽

Cited By ~ 1

Author(s):

Rui Lai ◽

Qiang Cui

Keyword(s):

Alkaline Phosphatase ◽

Transition State ◽

Protein Phosphatase ◽

Cluster Models ◽

Protein Phosphatase 1 ◽

Phosphoryl Transfer

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The Transition State of the Phosphoryl-Transfer Reaction Catalyzed by the Lambda Ser/Thr Protein Phosphatase

Journal of the American Chemical Society ◽

10.1021/ja990667p ◽

1999 ◽

Vol 121 (27) ◽

pp. 6382-6390 ◽

Cited By ~ 21

Author(s):

Richard H. Hoff ◽

Pamela Mertz ◽

Frank Rusnak ◽

Alvan C. Hengge

Keyword(s):

Transition State ◽

Protein Phosphatase ◽

Transfer Reaction ◽

Phosphoryl Transfer

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Does the Active Site Arginine Change the Nature of the Transition State for Alkaline Phosphatase-Catalyzed Phosphoryl Transfer?

Journal of the American Chemical Society ◽

10.1021/ja9932582 ◽

1999 ◽

Vol 121 (47) ◽

pp. 11022-11023 ◽

Cited By ~ 30

Author(s):

Patrick J. O'Brie ◽

Daniel Herschlag

Keyword(s):

Alkaline Phosphatase ◽

Transition State ◽

Active Site ◽

Phosphoryl Transfer

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The nature of the transition state for enzyme-catalyzed phosphoryl transfer. Hydrolysis of O-aryl phosphorothioates by alkaline phosphatase

Biochemistry ◽

10.1021/bi00038a021 ◽

1995 ◽

Vol 34 (38) ◽

pp. 12255-12264 ◽

Cited By ~ 69

Author(s):

Florian Hollfelder ◽

Daniel Herschlag

Keyword(s):

Alkaline Phosphatase ◽

Transition State ◽

Phosphoryl Transfer ◽

Hydrolysis Of

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Mutation of Arg-166 of Alkaline Phosphatase Alters the Thio Effect but Not the Transition State for Phosphoryl Transfer. Implications for the Interpretation of Thio Effects in Reactions of Phosphatases†

Biochemistry ◽

10.1021/bi000899x ◽

2000 ◽

Vol 39 (31) ◽

pp. 9451-9458 ◽

Cited By ~ 26

Author(s):

Kathleen M. Holtz ◽

Irina E. Catrina ◽

Alvan C. Hengge ◽

Evan R. Kantrowitz

Keyword(s):

Alkaline Phosphatase ◽

Transition State ◽

Phosphoryl Transfer

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Protein phosphatase-1 and -2A activities in heart, liver, and skeletal muscle extracts from control and diabetic rats

Diabetes ◽

10.2337/diabetes.33.6.576 ◽

1984 ◽

Vol 33 (6) ◽

pp. 576-579 ◽

Cited By ~ 4

Author(s):

J. G. Foulkes ◽

L. S. Jefferson

Keyword(s):

Skeletal Muscle ◽

Protein Phosphatase ◽

Diabetic Rats ◽

Protein Phosphatase 1

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Regulation of glycogen synthase and protein phosphatase-1 by hexosamines

Diabetes ◽

10.2337/diabetes.45.3.322 ◽

1996 ◽

Vol 45 (3) ◽

pp. 322-327 ◽

Cited By ~ 4

Author(s):

E. D. Crook ◽

D. A. McClain

Keyword(s):

Protein Phosphatase ◽

Glycogen Synthase ◽

Protein Phosphatase 1

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Faculty Opinions recommendation of Protein phosphatase 1 is a molecular constraint on learning and memory.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1008124.161508 ◽

2002 ◽

Author(s):

Angus Nairn

Keyword(s):

Learning And Memory ◽

Protein Phosphatase ◽

Protein Phosphatase 1

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Faculty Opinions recommendation of Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1102208.558219 ◽

2008 ◽

Author(s):

Shankar Venkatraman

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 1 ◽

Tat Protein ◽

Nuclear Targeting ◽

Hiv 1

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Faculty Opinions recommendation of Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1126855.583957 ◽

2008 ◽

Author(s):

Arieh Warshel

Keyword(s):

Transition State ◽

Magnesium Fluoride ◽

Phosphoryl Transfer ◽

Transition State Analogs ◽

Anionic Charge

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Faculty Opinions recommendation of Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2588956.2318054 ◽

2010 ◽

Author(s):

Laura Trinkle-Mulcahy

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 1 ◽

Aurora B ◽

Aurora B Kinase

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