scholarly journals Selective Synthesis of N-H and N-Aryl Benzotriazoles by the [3 + 2] Annulation of Sodium Azide with Arynes

2019 ◽  
Vol 84 (19) ◽  
pp. 12692-12699 ◽  
Author(s):  
Avishek Guin ◽  
Rahul N. Gaykar ◽  
Subrata Bhattacharjee ◽  
Akkattu T. Biju
Keyword(s):  
Sodium Azide ◽  
Selective Synthesis

Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources

2018 ◽  
Vol 20 (14) ◽  
pp. 3339-3345 ◽  
Author(s):  
Kaushik Chakrabarti ◽  
Anju Mishra ◽  
Dibyajyoti Panja ◽  
Bhaskar Paul ◽  
Sabuj Kundu
Keyword(s):  
Sodium Azide ◽  
Selective Synthesis ◽  
Organic Azides ◽  
Methylated Amines

The selective synthesis of various N,N-dimethylated and N-monomethylated amines from organic azides using methanol as a methylating agent is reported.

InCl3: an Airstable and Water-Tolerant Catalyst for the Selective Synthesis of 5-Aryl Tetrazole

2011 ◽  
Vol 396-398 ◽  
pp. 2416-2419 ◽  
Author(s):  
Hong Bin Sun ◽  
Wen Long Chen ◽  
Yuan Hua Sun ◽  
Peng Qin ◽  
Xuan Qi
Keyword(s):  
Sodium Azide ◽  
Selective Synthesis ◽  
Efficient Catalyst

5-Phenyl-1-H tetrazole was synthesized by catalytic [3+2] cycloaddition with benzonitrile and sodium azide. Indium trichloride was used as an efficient catalyst.

RetroBioCat: Computer-Aided Synthesis Planning for Biocatalytic Reactions and Cascades

2020 ◽  
Author(s):  
William Finnigan ◽  
Lorna J. Hepworth ◽  
Nicholas J. Turner ◽  
Sabine Flitsch
Keyword(s):  
Organic Chemistry ◽  
Computer Aided Design ◽  
Selective Synthesis ◽  
Test Set ◽  
Synthesis Design ◽  
Computer Aided ◽  
Synthesis Planning ◽  
Enzymatic Cascades ◽  
Target Molecules ◽  
Aided Design

As the enzyme toolbox for biocatalysis has expanded, so has the potential for the construction of powerful enzymatic cascades for efficient and selective synthesis of target molecules. Additionally, recent advances in computer-aided synthesis planning (CASP) are revolutionizing synthesis design in both synthetic biology and organic chemistry. However, the potential for biocatalysis is not well captured by tools currently available in either field. Here we present RetroBioCat, an intuitive and accessible tool for computer-aided design of biocatalytic cascades, freely available at retrobiocat.com. Our approach uses a set of expertly encoded reaction rules encompassing the enzyme toolbox for biocatalysis, and a system for identifying literature precedent for enzymes with the correct substrate specificity where this is available. Applying these rules for automated biocatalytic retrosynthesis, we show our tool to be capable of identifying promising biocatalytic pathways to target molecules, validated using a test-set of recent cascades described in the literature.

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

Sign in / Sign up

Export Citation Format

Share Document