Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)–N Bond Cleavage under Catalyst-Free Conditions

2019 ◽  
Vol 84 (18) ◽  
pp. 11823-11838 ◽  
Author(s):  
Popuri Sureshbabu ◽  
Sadaf Azeez ◽  
Nalluchamy Muniyappan ◽  
Shahulhameed Sabiah ◽  
Jeyakumar Kandasamy
Keyword(s):  
Bond Cleavage ◽  
Grignard Reagents ◽  
Catalyst Free ◽  
Chemoselective Synthesis ◽  
Aryl Ketones

Displacement of Nuclear Halogen Atoms in Hindered Aryl Ketones by the Action of Grignard Reagents

1954 ◽  
Vol 76 (20) ◽  
pp. 5119-5121
Author(s):  
Reynold C. Fuson ◽  
William S. Friedlander ◽  
George W. Parshall
Keyword(s):  
Grignard Reagents ◽  
Halogen Atoms ◽  
Aryl Ketones

ChemInform Abstract: Fe-Promoted Cross Coupling of Homobenzylic Methyl Ethers with Grignard Reagents via sp3C-O Bond Cleavage.

ChemInform ◽  
2013 ◽  
Vol 44 (52) ◽  
pp. no-no
Author(s):  
Shuang Luo ◽  
Da-Gang Yu ◽  
Ru-Yi Zhu ◽  
Xin Wang ◽  
Lei Wang ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Cross Coupling ◽  
Grignard Reagents

ChemInform Abstract: Nickel-Catalyzed Cross-Coupling of Anisoles with Alkyl Grignard Reagents via C-O Bond Cleavage.

ChemInform ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. no-no
Author(s):  
Mamoru Tobisu ◽  
Tsuyoshi Takahira ◽  
Naoto Chatani
Keyword(s):  
Bond Cleavage ◽  
Cross Coupling ◽  
Grignard Reagents

ChemInform Abstract: Extrusion of CO from Aryl Ketones: Rhodium(I)-Catalyzed C-C Bond Cleavage Directed by a Pyridine Group.

ChemInform ◽  
2012 ◽  
Vol 43 (29) ◽  
pp. no-no
Author(s):  
Zhi-Quan Lei ◽  
Hu Li ◽  
Yang Li ◽  
Xi-Sha Zhang ◽  
Kang Chen ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Pyridine Group ◽  
Aryl Ketones

Carbon–Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)–CF3 Bond Cleavage

2019 ◽  
Vol 84 (9) ◽  
pp. 5635-5644 ◽  
Author(s):  
Longzhi Zhu ◽  
Liyuan Le ◽  
Mingpan Yan ◽  
Chak-Tong Au ◽  
Renhua Qiu ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Bond Formation ◽  
Grignard Reagents ◽  
Carbon Bond ◽  
Carbon Carbon Bond

CH Functionalization/CO Bond Cleavage of Benzyl Silyl Ethers with Ynamides for the Chemoselective Synthesis of Skeletally Diverse Compounds

2016 ◽  
Vol 358 (3) ◽  
pp. 480-485 ◽  
Author(s):  
Ling Chen ◽  
Lian Yu ◽  
Yuan Deng ◽  
Zhan-Jiang Zheng ◽  
Zheng Xu ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Silyl Ethers ◽  
Chemoselective Synthesis

A Catalyst‐Free Domino Protocol for the Chemoselective Synthesis of Multifunctionalised Pyrroles in Aqueous MediaviaNitroketene‐N,S‐Acetal Chemistry

2018 ◽  
Vol 3 (23) ◽  
pp. 6334-6337 ◽  
Author(s):  
Ankita Chaudhary ◽  
Jitender M. Khurana ◽  
Garima Khanna ◽  
Mohit Saroha
Keyword(s):  
Catalyst Free ◽  
Chemoselective Synthesis

scholarly journals Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents

2019 ◽  
Vol 25 (1) ◽  
pp. 116-121
Author(s):  
Wei Zhou ◽  
Qingwei Xiao ◽  
Yuanyuan Chang ◽  
Qifa Liu ◽  
Xiaohao Zang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Chiral Auxiliary ◽  
Grignard Reagents ◽  
Amino Acid Derivatives ◽  
Catalyst Free ◽  
Chemical Efficiency

AbstractHerein is described a diastereoselective Michael addition of Grignard reagents to α, β- unsaturated diethyl malonates incorporated with a 2-oxazolidone chiral auxiliary. The catalyst-free Michael addition proceeds with good chemical efficiency and excellent stereoselectivity; and it provides new thoughts to the asymmetric synthesis of β-substituted β3 amino acid derivatives.

Sign in / Sign up

Export Citation Format

Share Document