Catalyst-Free Synthesis of 2,3-Dihydrobenzofurans via a Formal [4+1] Annulation of Propargylamines with Sulfur Ylides

2019 ◽  
Vol 84 (18) ◽  
pp. 11623-11638 ◽  
Author(s):  
Xinwei He ◽  
Mengqing Xie ◽  
Qiang Tang ◽  
Youpeng Zuo ◽  
Ruxue Li ◽  
...  
Keyword(s):  
Sulfur Ylides ◽  
Catalyst Free

Divergent synthesis of oxindole derivatives via controllable reactions of isatin-derived para-quinone methides with sulfur ylides

2020 ◽  
Vol 18 (24) ◽  
pp. 4560-4565 ◽  
Author(s):  
Yong You ◽  
Bao-Xue Quan ◽  
Zhen-Hua Wang ◽  
Jian-Qiang Zhao ◽  
Wei-Cheng Yuan
Keyword(s):  
Quinone Methides ◽  
Sulfur Ylides ◽  
Catalyst Free

A catalyst-free and controllable reaction of isatin-derived para-quinone methides with sulfur ylides was developed, and it enables the divergent synthesis of two valuable oxindoles.

Catalyst-free synthesis of 2,3-dihydrobenzofurans through [4+1] cycloaddition of ortho -hydroxyphenylsubstituted para- quinone methides and sulfur ylides

Tetrahedron ◽  
2018 ◽  
Vol 74 (5) ◽  
pp. 600-605 ◽  
Author(s):  
Xin-Meng Chen ◽  
Ke-Xin Xie ◽  
Deng-Feng Yue ◽  
Xiao-Mei Zhang ◽  
Xiao-Ying Xu ◽  
...  
Keyword(s):  
Quinone Methides ◽  
Sulfur Ylides ◽  
Catalyst Free

Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex

2020 ◽  
Author(s):  
José Tiago Menezes Correia ◽  
Gustavo Piva da Silva ◽  
Camila Menezes Kisukuri ◽  
Elias André ◽  
Bruno Pires ◽  
...  
Keyword(s):  
Electron Donor ◽  
Functional Group ◽  
Photoexcited Electron ◽  
One Pot ◽  
Quaternary Centers ◽  
Metal Free ◽  
Acceptor Complex ◽  
Catalyst Free ◽  
Donor Acceptor ◽  
Radical Cascade

A metal- and catalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a SET event involving a photoexcited electron-donor-aceptor complex between NHPI ester and Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the enyne. <a>The method provides an operationally simple, robust and step-economical approach to the construction of diversely functionalized dihydroquinolinones bearing quaternary-centers. A sequential one-pot hydroalkylation-isomerization approach is also allowed giving access to a family of quinolinones. A wide substrate scope and high functional group tolerance was observed in both approaches</a>.

PEG1000 as a Low Melting and Ecofriendly Solvent for Air Oxidative and Catalyst Free 2,4-Disubstitute Quinazoline Synthesis

2020 ◽  
Vol 17 (9) ◽  
pp. 709-716
Author(s):  
Ebrahim Saeedian Moghadam ◽  
Shahrzad Ghafary ◽  
Mohsen Amini
Keyword(s):  
Melting Point ◽  
High Yield ◽  
Purification Process ◽  
Poly Ethylene Glycol ◽  
Free Condition ◽  
Catalyst Free ◽  
Privileged Scaffold ◽  
Quinazoline Derivatives ◽  
Poly Ethylene ◽  
Work Up

With regard to the importance of quinazoline as a privileged scaffold, herein we report the synthesis of twenty seven 2,4-disubstitute quinazoline derivatives in a new catalyst free condition. In the current work, poly ethylene glycol (PEG1000) as an inexpensive, very simple commercially available, ecofriendly and low melting point solvent was used. Air bubbling, a green oxidant, for oxidation purpose was also used. This is the first report about using PEG1000 as a solvent simultaneously with air bubbling as oxidant in quinazoline synthesis. All of the compounds 1-27 were synthesized in high yield with very simple work up and purification process without using column chromatography. All the structures were confirmed using 1H NMR, 13C NMR, IR, MS and elemental analysis.

A New, Simple, Catalyst-free Method for the Synthesis of Pyrazolopyranopyrimidines in Magnetized Water

2017 ◽  
Vol 14 (7) ◽  
Author(s):  
Mohammad Bakherad ◽  
Rahele Doosti ◽  
Ali Keivanloo ◽  
Mostafa Gholizadeh ◽  
Amir H. Amin
Keyword(s):  
Catalyst Free ◽  
Magnetized Water

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Microwave-Assisted Aminolysis of Lactones Under Solvent- and Catalyst- Free Conditions

2017 ◽  
Vol 4 (2) ◽  
pp. 168-172 ◽  
Author(s):  
Angelica de Fatima S. Barreto ◽  
Carlos Eduardo M. Salvador ◽  
Thaissa Pasquali F. Rosalba ◽  
Carlos Kleber Z. Andrade
Keyword(s):  
Microwave Assisted ◽  
Catalyst Free
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