Solid-Phase Azopeptide Diels–Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation

2019 ◽  
Vol 84 (10) ◽  
pp. 6006-6016 ◽  
Author(s):  
Ramesh Chingle ◽  
Mukandila Mulumba ◽  
Nga N. Chung ◽  
Thi M.-D. Nguyen ◽  
Huy Ong ◽  
...  
Keyword(s):  
Solid Phase ◽  
Peptide Conformation ◽  
Diels Alder

Imino-Diels-Alder Reactions of 1-Aryl-3-(trialkylsiloxy)-1,3-butadienes in Solution and the Solid Phase

2008 ◽  
Vol 2008 (23) ◽  
pp. 4004-4014 ◽  
Author(s):  
Esther Caballero ◽  
Javier Figueroa ◽  
Pilar Puebla ◽  
Rafael Peláez ◽  
Fernando Tomé ◽  
...  
Keyword(s):  
Solid Phase ◽  
Diels Alder

ChemInform Abstract: Imino-Diels-Alder Reactions of 1-Aryl-3-(trialkylsiloxy)-1,3-butadienes in Solution and the Solid Phase.

ChemInform ◽  
2008 ◽  
Vol 39 (50) ◽  
Author(s):  
Esther Caballero ◽  
Javier Figueroa ◽  
Pilar Puebla ◽  
Rafael Pelaez ◽  
Fernando Tome ◽  
...  
Keyword(s):  
Solid Phase ◽  
Diels Alder

Stereoselective Aza Diels−Alder Reaction on Solid Phase:  A Facile Synthesis of Hexahydrocinnoline Derivatives

2007 ◽  
Vol 9 (2) ◽  
pp. 263-266 ◽  
Author(s):  
Alexandros Kiriazis ◽  
Tobias Rüffer ◽  
Sirkku Jäntti ◽  
Heinrich Lang ◽  
Jari Yli-Kauhaluoma
Keyword(s):  
Solid Phase ◽  
Alder Reaction ◽  
Diels Alder ◽  
Facile Synthesis ◽  
Diels Alder Reaction

scholarly journals Natural Product-Derived Modulators of Cell Cycle Progression and Viral Entry by Enantioselective Oxa Diels-Alder Reactions on the Solid Phase

2007 ◽  
Vol 14 (4) ◽  
pp. 443-451 ◽  
Author(s):  
Torben Leßmann ◽  
Michele G. Leuenberger ◽  
Sascha Menninger ◽  
Meritxell Lopez-Canet ◽  
Oliver Müller ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Natural Product ◽  
Viral Entry ◽  
Cell Cycle Progression ◽  
Solid Phase ◽  
Diels Alder ◽  
Cycle Progression

scholarly journals Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions

2019 ◽  
Vol 10 (45) ◽  
pp. 10481-10492 ◽  
Author(s):  
Marco Potowski ◽  
Florian Losch ◽  
Elena Wünnemann ◽  
Janina K. Dahmen ◽  
Silvia Chines ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Dna Sequences ◽  
Solid Phase ◽  
Alder Reaction ◽  
Solid Support ◽  
Diels Alder ◽  
Dna Oligonucleotides ◽  
Compound Libraries ◽  
Diels Alder Reaction ◽  
Selection Of

DNA-encoded compound libraries are widely used in drug discovery. Screening of catalysts for compatibility with solid phase-coupled DNA sequences guided the selection of encoded reactions, exemplified by a Zn(II)-mediated aza-Diels–Alder reaction.

Hetero-Diels-Alder Reactions in the Synthesis of Biologically Active Nitrogen Compounds: A Review

2018 ◽  
Vol 15 (1) ◽  
pp. 84-104 ◽  
Author(s):  
Andre F. Constantino ◽  
Carla S. Francisco ◽  
Diana C. Cubides-Roman ◽  
Valdemar Lacerda
Keyword(s):  
Organic Chemistry ◽  
Solid Phase ◽  
Biological Properties ◽  
Alder Reaction ◽  
Diels Alder ◽  
Biologically Active ◽  
Nitrogen Compounds ◽  
Active Nitrogen ◽  
Polycyclic Compounds ◽  
Wide Range

Background: The Hetero-Diels-Alder reaction (HDAR) is a method extensively used in organic chemistry as a tool in the synthesis of innumerous polycyclic compounds in particular nitrogen compounds, presents in many natural products, medicinally relevant substances and organic materials. The literature describes innumerable studies of HDAR using classic methods and modern developments such as reactions on the solid phase, the use of catalysts, transformations in aqueous solution and under microwaves. Objective: This review describes a variety of HDAR focused on obtaining nitrogen-containing compounds of considerable chemical and biological interest, and highlighting reported biological activity. Conclusion: This review has shown the importance of the HDA reaction as a tool of organic chemistry in the synthesis of nitrogen compounds. This type of reaction presents important properties including bond-forming economy, high regio- and stereoselectivities and thus provides highly efficient routes to access a wide range of polycyclic compounds. In addition to the variety of nitrogen compounds synthetized successfully by this method, they present relevant biological properties.

Sign in / Sign up

Export Citation Format

Share Document