Synthesis and Biological Evaluation of 6-[(1R)-1-Hydroxyethyl]-2,4a(R),6(S),8a(R)-tetrahydropyrano-[3,2-b]-pyran-2-one and Structural Analogues of the Putative Structure of Diplopyrone

2018 ◽  
Vol 84 (2) ◽  
pp. 666-678 ◽  
Author(s):  
Nicholas C. Lazzara ◽  
Robert J. Rosano ◽  
Purav P. Vagadia ◽  
Matthew T. Giovine ◽  
Mark W. Bezpalko ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Structural Analogues ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues

MedChemComm ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 1445-1456 ◽  
Author(s):  
Casey J. Maguire ◽  
Graham J. Carlson ◽  
Jacob W. Ford ◽  
Tracy E. Strecker ◽  
Ernest Hamel ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Conformationally Restricted ◽  
Structural Analogues ◽  
Synthesis And Biological Evaluation

Cyclic chalcones and structural analogues evaluated as cytotoxic agents.

Protecting-Group-Free Total Synthesis and Biological Evaluation of 3-Methylkealiiquinone and Structural Analogues

2018 ◽  
Vol 83 (17) ◽  
pp. 10627-10635 ◽  
Author(s):  
Velayudham Ramadoss ◽  
Angel Josabad Alonso-Castro ◽  
Nimsi Campos-Xolalpa ◽  
César R. Solorio-Alvarado
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Protecting Group ◽  
Structural Analogues ◽  
Synthesis And Biological Evaluation

SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-PHENYLPYRIDO[2,3-D] PYRIMIDINE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (05) ◽  
pp. 50-58
Author(s):  
P. V Bhagwanrao ◽  
◽  
P. G. Ingole ◽  
S. R Butle
Keyword(s):  
Mcf7 Cell ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Cdk Inhibitors ◽  
Cyclin Dependent Kinase ◽  
Pyrimidine Derivatives ◽  
Structural Analogues ◽  
Novel Scaffold ◽  
Synthesis And Biological Evaluation ◽  
Breast Cancer Mcf7 Cell

We report a novel scaffold of 2-phenylpyrido[2,3-d]pyrimidine derivatives designed as structural analogues of dinaciclib. Sixteen derivatives were synthesised and evaluated for their CDK2/5 inhibition activity. Compounds 4-(2-(3-methoxybenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7i) and 4-(2-(3-nitrobenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7n) show promising IC50 and kinase selectivity. These compounds also show moderate anti-proliferative activity in the colon cancer HCT116 and breast cancer MCF7 cell lines. In molecular docking studies with CDK2, compounds 7i and 7nshow binding similar to dinaciclib.

Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase

2015 ◽  
Vol 101 ◽  
pp. 133-149 ◽  
Author(s):  
Katja Wiechmann ◽  
Hans Müller ◽  
Volker Huch ◽  
David Hartmann ◽  
Oliver Werz ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Structural Analogues ◽  
Synthesis And Biological Evaluation
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