Rh(III)-Catalyzed C(8)–H Functionalization of Quinolines via Simultaneous C–C and C–O Bond Formation: Direct Synthesis of Quinoline Derivatives with Antiplasmodial Potential

2018 ◽  
Vol 83 (20) ◽  
pp. 12702-12710 ◽  
Author(s):  
Ritika Sharma ◽  
Rakesh Kumar ◽  
Rohit Kumar ◽  
Pooja Upadhyay ◽  
Dinkar Sahal ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Bond Formation ◽  
Quinoline Derivatives

scholarly journals N–N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2-Substituted Indazolones with Mechanistic Insights

2018 ◽  
Vol 20 (16) ◽  
pp. 4736-4739 ◽  
Author(s):  
Jie S. Zhu ◽  
Niklas Kraemer ◽  
Marina E. Shatskikh ◽  
Clarabella J. Li ◽  
Jung-Ho Son ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Bond Formation ◽  
Primary Amines

Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides

2019 ◽  
Vol 17 (24) ◽  
pp. 5902-5907 ◽  
Author(s):  
Ping-Gui Li ◽  
Hao Zhu ◽  
Min Fan ◽  
Cheng Yan ◽  
Kai Shi ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Bond Formation ◽  
Aldehyde Group ◽  
Keto Acids

Copper-catalyzed coupling of α-keto acids with anthranils is reported for the synthesis of α-ketoamides bearing an aldehyde group via N–O/C–O bond cleavages and C–N bond formation.

scholarly journals PIDA-mediated intramolecular oxidative C–N bond formation for the direct synthesis of quinoxalines from enaminones

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 7718-7722 ◽  
Author(s):  
Hong Zhang ◽  
Jinhai Shen ◽  
Zhenhui Yang ◽  
Xiuling Cui
Keyword(s):  
Direct Synthesis ◽  
Bond Formation ◽  
Hypervalent Iodine ◽  
Mild Conditions

An expedient hypervalent iodine(iii)-mediated approach to obtain substituted quinoxalines from readily available enaminones has been developed under mild conditions.

Direct Synthesis of 6H-Chromeno[3,4-b]quinolin-6-ol Derivatives from Substituted 3-Nitro-2H-chromenes and 2-Nitrobenzaldehydes Mediated by Fe/AcOH System

Synthesis ◽  
2017 ◽  
Vol 50 (06) ◽  
pp. 1350-1358 ◽  
Author(s):  
Cunde Wang ◽  
Xushun Qing ◽  
Ting Wang ◽  
Chenlu Dai ◽  
Zhenjie Su
Keyword(s):  
Acetic Acid ◽  
Nucleophilic Addition ◽  
Aldol Condensation ◽  
Direct Synthesis ◽  
Reductive Cyclization ◽  
Quinoline Derivatives ◽  
Acid System ◽  
X Ray ◽  
X Ray Crystallography ◽  
Sequential Reduction

An efficient iron/acetic acid system-mediated reductive cyclization reaction of substituted 2-aryl-3-nitro-2H-chromenes with substituted 2-nitrobenzaldehydes for the synthesis of 6-aryl-6H-chromeno[3,4-b]quinolines was developed. This reaction involves the sequential reduction, hydrolysis, aldol condensation, intramolecular addition, and the nucleophilic addition of substituted 2-aryl-3-nitro-2H-chromenes with substituted 2-nitrobenzaldehydes to give the corresponding 6H-chromeno[3,4-b]quinolines. This transformation provides a straightforward synthetic protocol for constructing substituted 6H-chromeno[3,4-b]quinoline derivatives. The structures of three typical products were confirmed by X-ray crystallography.

scholarly journals A Novel Direct Synthesis of theN-Oxides of Quinoline Derivatives

1966 ◽  
Vol 39 (1) ◽  
pp. 195-195 ◽  
Author(s):  
Yusuf Ahmad ◽  
Shamim Ahmad Shamsi
Keyword(s):  
Direct Synthesis ◽  
Quinoline Derivatives
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