scholarly journals Lewis Acid-Catalyzed Diastereoselective Synthesis of MultisubstitutedN-Acylaziridine-2-carboxamides from 2H-Azirines via Joullié–Ugi Three-Component Reaction

2018 ◽  
Vol 83 (7) ◽  
pp. 3570-3581 ◽  
Author(s):  
Anikó Angyal ◽  
András Demjén ◽  
Edit Wéber ◽  
Anita K. Kovács ◽  
János Wölfling ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Diastereoselective Synthesis ◽  
Three Component Reaction ◽  
Acid Catalyzed

scholarly journals A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles

2019 ◽  
Vol 15 ◽  
pp. 1061-1064 ◽  
Author(s):  
Alexei Lukin ◽  
Anna Bakholdina ◽  
Anna Kryukova ◽  
Alexander Sapegin ◽  
Mikhail Krasavin
Keyword(s):  
Lewis Acid ◽  
Primary Amine ◽  
Three Component Reaction ◽  
Acid Catalyzed ◽  
In Situ Generation

A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)2-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported base-promoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.

Diastereoselective Synthesis of Cycloheptannelated Indoles via Lewis-Acid-Catalyzed (4 + 3)-Cyclization of Donor–Acceptor Cyclopropanes

2020 ◽  
Vol 22 (5) ◽  
pp. 1903-1907 ◽  
Author(s):  
Bao Qiong Li ◽  
Zong-Wang Qiu ◽  
Ai-Jun Ma ◽  
Jin-Bao Peng ◽  
Na Feng ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Diastereoselective Synthesis ◽  
Donor Acceptor ◽  
Acid Catalyzed

Lewis Acid-Catalyzed Intermolecular Annulation: Three-Component Reaction toward Imidazo[1,2-a]pyridine Thiones

2019 ◽  
Vol 84 (14) ◽  
pp. 9369-9377 ◽  
Author(s):  
Zhengwang Chen ◽  
Pei Liang ◽  
Fan Xu ◽  
Rulin Qiu ◽  
Qi Tan ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Three Component Reaction ◽  
Acid Catalyzed

Lewis acid catalyzed diastereoselective [3+4]-annulation of donor–acceptor cyclopropanes with anthranils: synthesis of tetrahydro-1-benzazepine derivatives

2017 ◽  
Vol 53 (61) ◽  
pp. 8521-8524 ◽  
Author(s):  
Zhe-Hao Wang ◽  
Huan-Huan Zhang ◽  
Dao-Ming Wang ◽  
Peng-Fei Xu ◽  
Yong-Chun Luo
Keyword(s):  
Lewis Acid ◽  
Diastereoselective Synthesis ◽  
Donor Acceptor ◽  
Acid Catalyzed

The [3+4]-annulation between donor–acceptor cyclopropanes and anthranils has been developed for the diastereoselective synthesis of tetrahydro-1-benzazepine derivatives.

scholarly journals Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers

Synthesis ◽  
2017 ◽  
Vol 49 (18) ◽  
pp. 4229-4246 ◽  
Author(s):  
Arun Ghosh ◽  
Anthony Tomaine ◽  
Kelsey Cantwell
Keyword(s):  
Natural Products ◽  
Drug Design ◽  
Lewis Acid ◽  
Medicinal Chemistry ◽  
Cyclic Ether ◽  
Cyclic Ethers ◽  
Diastereoselective Synthesis ◽  
Acid Catalyzed

Cyclic ethers are widely abundant in natural products. Cyclic ether templates are also utilized in drug design and medicinal chemistry. Although the synthetic processes for this class of compounds have been studied extensively with respect to five- and six-membered rings, medium-sized cyclic ethers are synthetically more challenging due to a variety of factors. Herein, we report our results on the Lewis acid catalyzed synthesis of medium-sized cyclic ethers in a diastereoselective manner.

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