Camphorsulfonic Acid Catalyzed One-Pot Three-Component Reaction for the Synthesis of Fused Quinoline and Benzoquinoline Derivatives

2017 ◽  
Vol 82 (23) ◽  
pp. 12416-12429 ◽  
Author(s):  
Radhakrishna Gattu ◽  
Prasanta Ray Bagdi ◽  
R. Sidick Basha ◽  
Abu T. Khan
Keyword(s):  
Camphorsulfonic Acid ◽  
One Pot ◽  
Three Component Reaction ◽  
Acid Catalyzed

Three-component 3-(phosphoryl)methylindole synthesis from indoles, H-phosphine oxides and carbonyl compounds under metal-free conditions

2019 ◽  
Vol 21 (4) ◽  
pp. 792-797 ◽  
Author(s):  
Jiaoting Pan ◽  
Runmin Zhao ◽  
Jiami Guo ◽  
Dumei Ma ◽  
Ying Xia ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Indole Derivatives ◽  
Phosphine Oxides ◽  
One Pot ◽  
Metal Free ◽  
Three Component Reaction ◽  
Acid Catalyzed

The first facile and efficient acid-catalyzed three-component reaction of indoles, H-phosphine oxides and carbonyl compounds has been developed, providing a general, one-pot approach to structurally diverse C3-alkylated indole derivatives.

One-Pot Synthesis of 1,4-Dihydropyridines via a Phenylboronic Acid Catalyzed Hantzsch Three-Component Reaction

Synlett ◽  
2008 ◽  
Vol 2008 (04) ◽  
pp. 509-512 ◽  
Author(s):  
Abdelmadjid Debache ◽  
Raouf Boulcina ◽  
Ali Belfaitah ◽  
Salah Rhouati ◽  
Bertrand Carboni
Keyword(s):  
Phenylboronic Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
Acid Catalyzed

One-Pot Synthesis of N -Alkyl Benzotriazoles via a Brønsted Acid-Catalyzed Three-Component Reaction

2017 ◽  
Vol 360 (2) ◽  
pp. 374-378 ◽  
Author(s):  
Xiangdong Wang ◽  
Chunqi Jia ◽  
Yadong Feng ◽  
Lianhui Wang ◽  
Xiuling Cui
Keyword(s):  
Bronsted Acid ◽  
Brønsted Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Brönsted Acid ◽  
Three Component Reaction ◽  
Acid Catalyzed

scholarly journals Acid Catalyzed Multicomponent One-Pot Synthesis of New Quinazolinone based Unsymmetrical C-N Linked Bis Heterocycles

2022 ◽  
Vol 34 (2) ◽  
pp. 432-436
Author(s):  
Nagamani Rayala ◽  
Sumathi Vodnala ◽  
Supriya Kamsani ◽  
A.K.D. Bhavani ◽  
Nagaraju Myakala ◽  
...  
Keyword(s):  
Hydrochloric Acid ◽  
13C Nmr ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Heterocyclic Ring ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Hybrid Compounds ◽  
Three Component Reaction ◽  
Acid Catalyzed

A novel series of unsymmetrical C-N linked bis heterocycles bearing quinazolinone and acridinedione skeletons have been synthesized in an acid promoted one pot multicomponent reaction. A blend of 6-aminoquinazolin-4-(3H)-one, aromatic aldehydes and cyclohexane-1,3-dione in a simple and efficient condensation-cyclization reaction using hydrochloric acid in catalytic amount as catalyst afforded unsymmetrical bis hybrids in good to excellent yields. Multiheterocyclic hybrid compounds were also synthesized using heterocyclic ring containing aldehyde in three component reaction. The synthesized quinazolinone-acridindione hybrids were characterized using spectroscopic techniques such as a IR, 1H NMR, 13C NMR, ESI-mass and HRMS.

ChemInform Abstract: One-Pot Synthesis of 1,4-Dihydropyridines via a Phenylboronic Acid Catalyzed Hantzsch Three-Component Reaction.

ChemInform ◽  
2008 ◽  
Vol 39 (27) ◽  
Author(s):  
Abdelmadjid Debache ◽  
Raouf Boulcina ◽  
Ali Belfaitah ◽  
Salah Rhouati ◽  
Bertrand Carboni
Keyword(s):  
Phenylboronic Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
Acid Catalyzed

Synthesis of novel series of 7,7′-(substituted methylene)bis-imidazo[1,2-b]pyrazoles via an acid catalyzed one-pot three-component reaction

2018 ◽  
Vol 42 (8) ◽  
pp. 5728-5741 ◽  
Author(s):  
Mohsine Driowya ◽  
Hassan Allouchi ◽  
José Manuel Gally ◽  
Pascal Bonnet ◽  
Gérald Guillaumet
Keyword(s):  
Aromatic Aldehydes ◽  
Acid Catalysts ◽  
Rapid Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
Acid Catalyzed ◽  
High Yields ◽  
Substituted Pyrazoles

An efficient and rapid synthesis of new series of N-alkyl-2-aryl-5H-imidazo[1,2-b]pyrazoles has been achieved in high yields through a three-component reaction of 3-amino-4-substituted pyrazoles, aromatic aldehydes and isocyanides mediated by acid catalysts.

Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

2013 ◽  
Vol 10 (7) ◽  
pp. 463-467 ◽  
Author(s):  
Imene Sehout ◽  
Raouf Boulcina ◽  
Boudjemaa Boumoud ◽  
Fabienne Berree ◽  
Bertrand Carboni ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Biginelli Reaction ◽  
One Pot ◽  
Green Approach ◽  
Acid Catalyzed

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Design, Synthesis, In vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-a]Pyridines as Potent Anti-Breast Cancer Agents

2019 ◽  
Vol 19 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Faeze Khalili ◽  
Sara Akrami ◽  
Malihe Safavi ◽  
Maryam Mohammadi-Khanaposhtani ◽  
Mina Saeedi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
High Yield ◽  
Breast Cancer Cell Lines ◽  
Pyridine Derivatives ◽  
One Pot ◽  
Standard Drug ◽  
Three Component Reaction ◽  
Anti Cancer

Background: This paper reports synthesis, cytotoxic activity, and apoptosis inducing effect of a novel series of styrylimidazo[1,2-a]pyridine derivatives. Objective: In this study, anti-cancer activity of novel styrylimidazo[1,2-a]pyridines was evaluated. Methods: Styrylimidazo[1,2-a]pyridine derivatives 4a-o were synthesized through a one-pot three-component reaction of 2-aminopyridines, cinnamaldehydes, and isocyanides in high yield. All synthesized compounds 4a-o were evaluated against breast cancer cell lines including MDA-MB-231, MCF-7, and T-47D using MTT assay. Apoptosis was evaluated by acridine orange/ethidium bromide staining, cell cycle analysis, and TUNEL assay as the mechanism of cell death. Results: Most of the synthesized compounds exhibited more potent cytotoxicity than standard drug, etoposide. Induction of apoptosis by the most cytotoxic compounds 4f, 4g, 4j, 4n, and 4m was confirmed through mentioned methods. Conclusion: In conclusion, these results confirmed the potency of styrylimidazo[1,2-a]pyridines for further drug discovery developments in the field of anti-cancer agents.

Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones

2017 ◽  
Vol 3 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Sunetra Jadhav ◽  
Ajinkya Patravale ◽  
Reshma Patil ◽  
Digambar Kumbhar ◽  
Vishram Karande ◽  
...  
Keyword(s):  
Sulfamic Acid ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Acid Catalyzed
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