Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives

2017 ◽  
Vol 82 (19) ◽  
pp. 9946-9954 ◽  
Author(s):  
Hong-Lei Li ◽  
Xiao-Ming Li ◽  
Attila Mándi ◽  
Sándor Antus ◽  
Xin Li ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Cladosporium Cladosporioides ◽  
Marine Algal

scholarly journals Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 213
Author(s):  
Xiao-Shan Shi ◽  
Yin-Ping Song ◽  
Ling-Hong Meng ◽  
Sui-Qun Yang ◽  
Dun-Jia Wang ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Micrococcus Luteus ◽  
Crystallographic Analysis ◽  
Medicinal Herb ◽  
Trichoderma Virens ◽  
Isolation And Characterization ◽  
Artemisia Argyi ◽  
Detailed Interpretation ◽  
Fungal Kingdom

Carotane sesquiterpenes are commonly found in plants but are infrequently reported in the fungal kingdom. Chemical investigation of Trichoderma virens QA-8, an endophytic fungus associated with the inner root tissue of the grown medicinal herb Artemisia argyi H. Lév. and Vaniot, resulted in the isolation and characterization of five new carotane sesquiterpenes trichocarotins I–M (1–5), which have diverse substitution patterns, and seven known related analogues (6–12). The structures of these compounds were established on the basis of a detailed interpretation of their NMR and mass spectroscopic data, and the structures including the relative and absolute configurations of compounds 1–3, 5, 9, and 10 were confirmed by X-ray crystallographic analysis. In the antibacterial assays, all isolates exhibited potent activity against Escherichia coli EMBLC-1, with MIC values ranging from 0.5 to 32 µg/mL, while 7β-hydroxy CAF-603 (7) strongly inhibited Micrococcus luteus QDIO-3 (MIC = 0.5 µg/mL). Structure-activity relationships of these compounds were discussed. The results from this study demonstrate that the endophytic fungus T. virens QA-8 from the planted medicinal herb A. argyi is a rich source of antibacterial carotane sesquiterpenes, and some of them might be interesting for further study to be developed as novel antibacterial agents.

scholarly journals Antifungal Activity against Plant Pathogens of Metabolites from the Endophytic Fungus Cladosporium cladosporioides

2013 ◽  
Vol 61 (19) ◽  
pp. 4551-4555 ◽  
Author(s):  
Xiaoning Wang ◽  
Mohamed M. Radwan ◽  
Amer H. Taráwneh ◽  
Jiangtao Gao ◽  
David E. Wedge ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Endophytic Fungus ◽  
Plant Pathogens ◽  
Cladosporium Cladosporioides
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