In Situ Generated TEMPO Oxoammonium Salt Mediated Tandem Cyclization of β-Oxoamides with Amine Hydrochlorides for the Synthesis of Pyrrolin-4-ones

2017 ◽  
Vol 82 (12) ◽  
pp. 6125-6132 ◽  
Author(s):  
Xuna Zhao ◽  
Tong-Xin Liu ◽  
Nana Ma ◽  
Guisheng Zhang
Keyword(s):  
Tandem Cyclization ◽  
Oxoammonium Salt ◽  
Amine Hydrochlorides

Lewis acid-catalyzed tandem cyclization of in situ generated o-quinone methides and arylsulfonyl hydrazides for a one-pot entry to 3-sulfonylbenzofurans

2019 ◽  
Vol 6 (24) ◽  
pp. 3929-3933 ◽  
Author(s):  
Fan-Xiao Meng ◽  
Ruo-Nan Wang ◽  
Hong-Li Huang ◽  
Shu-Wen Gong ◽  
Qian-Li Li ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Quinone Methides ◽  
One Pot ◽  
Acid Catalyzed ◽  
Tandem Cyclization ◽  
First Time

Lewis acid-mediated one-pot tandem cyclization of o-QMs with arylsulfonyl hydrazides was described for the first time and the corresponding 3-sulfonylbenzofuran products were obtained in moderate to good yields.

Synthesis of 4-styrylcoumarins via FeCl3-promoted cascade reactions of propargylamines with β-keto esters

2019 ◽  
Vol 17 (16) ◽  
pp. 4005-4013 ◽  
Author(s):  
Li-Qin Yan ◽  
Xiaoting Cai ◽  
Xinwei He ◽  
Hui Wang ◽  
Mengqing Xie ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cyclization Reaction ◽  
Quinone Methides ◽  
Keto Esters ◽  
Tandem Cyclization

A versatile and highly regioselective FeCl3-promoted tandem cyclization reaction of in situ generated alkynyl o-quinone methides (o-AQMs) with β-keto esters has been developed.

Acetic acid promoted tandem cyclization of in situ generated 1,3-dipoles: stereoselective synthesis of dispiroimidazolidinyl and dispiropyrrolidinyl oxindoles with multiple chiral stereocenters

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 79413-79422 ◽  
Author(s):  
Koorathota Suman ◽  
Sathiah Thennarasu
Keyword(s):  
Acetic Acid ◽  
Stereoselective Synthesis ◽  
Single Step ◽  
Pyrrolidine Ring ◽  
Acid Catalyzed ◽  
Chiral Centers ◽  
Tandem Cyclization

Acetic acid catalyzed in situ generation of ketimine based 1,3-dipoles, and single-step construction of imidazolidine ring with three chiral centers and pyrrolidine ring with four chiral centers via formation of new C–N and C–C bonds is reported.

Bioinspired Cyclization of in Situ Generated γ-Indolyl β,γ-Unsaturated α-Keto Esters via Oxidative Enamine Process: Facile Approaches to Pyrano[2,3-b]indoles

2021 ◽  
Author(s):  
Man Wang ◽  
Qirui Xiang ◽  
Wen Si ◽  
Ran Song ◽  
Daoshan Yang ◽  
...  
Keyword(s):  
Keto Esters ◽  
Mild Conditions ◽  
Oxoammonium Salt

A bioinspired cyclization of in situ generated -indolyl ,-unsaturated -ketoester with an oxoammonium salt via oxidative enamine process has been developed. Under mild conditions, the reactions afforded pyrano[2,3-b]indoles, which feature...

Metal-Free Synthesis of Pyrrolo[1,2-a]quinoxalines Mediated by TEMPO Oxoammonium Salts

Synthesis ◽  
2018 ◽  
Vol 50 (14) ◽  
pp. 2727-2740 ◽  
Author(s):  
Xiang-Ying Tang ◽  
Yue-fa Gong ◽  
Heng-rui Huo
Keyword(s):  
Carbonyl Compounds ◽  
One Pot ◽  
Metal Free ◽  
Oxoammonium Salts ◽  
One Pot Synthesis ◽  
Oxoammonium Salt

We herein describe a novel TEMPO oxoammonium salt initiated Pictet–Spengler reaction of imines, generated in situ from carbonyl compounds and pyrrole- or indole-containing substrates, to afford 4,5-dihydropyrrolo[1,2-a]quinoxalines or 5,6-dihydroindolo[1,2-a]quin­oxalines in good to excellent yields. Moreover, a one-pot synthesis of a biologically important quinoxaline is achieved via a cyclization–dehydrogenation process using one equivalent of the oxoammonium salt.

Tandem cyclization/arylation of diaryliodoniums via in situ constructed benzoxazole as a directing group for atom-economical transformation

2022 ◽  
Author(s):  
Daqian Zhu ◽  
Hui Peng ◽  
Qian Liu ◽  
Yameng Sun ◽  
Bingling Luo ◽  
...  
Keyword(s):  
Metal System ◽  
Directing Group ◽  
Tandem Cyclization ◽  
Palladium Metal

Linear diaryliodoniums often undergo only single arylation and leave equivalent aryliodide as waste. Herein, we demonstrate that linear unsymmetrical diaryliodoniums could be tuned by dual nickel/palladium metal system to accomplish...

Palladium-Catalyzed Tandem Cyclization—Anion Capture Processes. Part 8. In situ and Preformed Organostannanes. Carbamyl Chlorides and Other Starter Species.

ChemInform ◽  
2006 ◽  
Vol 37 (32) ◽  
Author(s):  
Usman Anwar ◽  
Mark R. Fielding ◽  
Ronald Grigg ◽  
Visuvanathar Sridharan ◽  
Christopher J. Urch
Keyword(s):  
Palladium Catalyzed ◽  
Tandem Cyclization
Sign in / Sign up

Export Citation Format

Share Document