Acyclic αγα-Tripeptides with Fluorinated- and Nonfluorinated-Furanoid Sugar Framework: Importance of Fluoro Substituent in Reverse-Turn Induced Self-Assembly and Transmembrane Ion-Transport Activity

2017 ◽  
Vol 82 (11) ◽  
pp. 5826-5834 ◽  
Author(s):  
Sachin S. Burade ◽  
Sopan Valiba Shinde ◽  
Naresh Bhuma ◽  
Navanath Kumbhar ◽  
Amol Kotmale ◽  
...  
Keyword(s):  
Ion Transport ◽  
Self Assembly ◽  
Transport Activity ◽  
Reverse Turn

Self-assembly of crown ether-based amphiphiles for constructing synthetic ion channels: the relationship between structure and transport activity

2014 ◽  
Vol 38 (8) ◽  
pp. 3507-3513 ◽  
Author(s):  
Tao Liu ◽  
Chunyan Bao ◽  
Haiyan Wang ◽  
Linbo Fei ◽  
Rongyan Yang ◽  
...  
Keyword(s):  
Ion Channels ◽  
Crown Ether ◽  
Ion Transport ◽  
Self Assembly ◽  
Molecular Structures ◽  
Transport Activity ◽  
Synthetic Ion Channels ◽  
The Relationship

Efficient ion transport was achieved from crown ether amphiphile-based ion channels by simply regulating the molecular structures.

scholarly journals Redesigning Channel-Forming Peptides: Amino Acid Substitutions that Enhance Rates of Supramolecular Self-Assembly and Raise Ion Transport Activity

2006 ◽  
Vol 90 (6) ◽  
pp. 2138-2150 ◽  
Author(s):  
Lalida P. Shank ◽  
James R. Broughman ◽  
Wade Takeguchi ◽  
Gabriel Cook ◽  
Ashley S. Robbins ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ion Transport ◽  
Self Assembly ◽  
Amino Acid Substitutions ◽  
Transport Activity

Trans Membrane Domain IV Is Involved in Ion Transport Activity and pH Regulation of the NhaA-Na+/H+Antiporter ofEscherichia coli†

Biochemistry ◽  
2002 ◽  
Vol 41 (2) ◽  
pp. 609-617 ◽  
Author(s):  
Livnat Galili ◽  
Andrea Rothman ◽  
Lena Kozachkov ◽  
Abraham Rimon ◽  
Etana Padan
Keyword(s):  
Ion Transport ◽  
Ph Regulation ◽  
Ofescherichia Coli ◽  
Transport Activity ◽  
Membrane Domain

scholarly journals Supramolecular Self‐Assembly of Nanoconfined Ionic Liquids for Fast Anisotropic Ion Transport

2019 ◽  
Vol 29 (49) ◽  
pp. 1905054 ◽  
Author(s):  
Tomy Cherian ◽  
Danilo Rosa Nunes ◽  
Thomas G. Dane ◽  
Johan Jacquemin ◽  
Ulla Vainio ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Ion Transport ◽  
Self Assembly

Modulating Ion Transport and Self-Assembly of Polymer Electrolytes via End-Group Chemistry

2017 ◽  
Vol 50 (8) ◽  
pp. 3224-3233 ◽  
Author(s):  
Ha Young Jung ◽  
Prithwiraj Mandal ◽  
Gyuha Jo ◽  
Onnuri Kim ◽  
Minju Kim ◽  
...  
Keyword(s):  
Ion Transport ◽  
Polymer Electrolytes ◽  
Self Assembly ◽  
End Group

Ion transport mediated by copolymers composed of polyoxyethylene and polyoxypropylene

1988 ◽  
Vol 254 (1) ◽  
pp. C20-C26 ◽  
Author(s):  
T. P. Atkinson ◽  
J. O. Bullock ◽  
T. F. Smith ◽  
R. E. Mullins ◽  
R. L. Hunter
Keyword(s):  
Ion Transport ◽  
Lipid Bilayers ◽  
Practical Interest ◽  
Water Soluble ◽  
Planar Lipid Bilayers ◽  
Monovalent Cations ◽  
Transport Activity ◽  
Experimental Systems ◽  
Surface Active Agents ◽  
Surface Active

Block copolymers composed of polyoxyethylene and polyoxypropylene were found to increase the influx of Na+ and the efflux of K+ from human erythrocytes. They were, however, ineffective at promoting the transport of Ca2+. The size of the ion fluxes induced by the copolymers correlated with their efficacy in stimulating inflammation. These compounds were also found to induce conductance increases in planar lipid bilayers in a nonvoltage dependent and nonstepwise manner. In both experimental systems, ion transport was facilitated only under temperature and ionic-strength conditions in which the polymers form aggregates in aqueous solution. In neither system did the concentration dependence of transport activity exhibit a pronounced cooperativity. These observations are consistent with the view that aqueous monomers of these surface active agents partition into the membrane, where they facilitate the conductive movement of monovalent cations by means of a carrier type mechanism. As a novel class of ionophores, these substances are of practical interest because they can be water soluble and are potentially reversible.

Altered pHi regulation and Na+/HCO3− transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouse

2007 ◽  
Vol 292 (4) ◽  
pp. C1409-C1416 ◽  
Author(s):  
Boglarka Banizs ◽  
Peter Komlosi ◽  
Mark O. Bevensee ◽  
Erik M. Schwiebert ◽  
Phillip D. Bell ◽  
...  
Keyword(s):  
Ion Transport ◽  
Choroid Plexus ◽  
Perinatal Period ◽  
Ependymal Cells ◽  
Intracellular Camp ◽  
Transport Activity ◽  
Wild Type ◽  
Choroid Plexus Epithelium ◽  
Fluid Movement ◽  
Camp Levels

Tg737 orpk mice have defects in cilia assembly and develop hydrocephalus in the perinatal period of life. Hydrocephalus is progressive and is thought to be initiated by abnormal ion and water transport across the choroid plexus epithelium. The pathology is further aggravated by the slow and disorganized beating of motile cilia on ependymal cells that contribute to decreased cerebrospinal fluid movement through the ventricles. Previously, we demonstrated that the hydrocephalus phenotype is associated with a marked increase in intracellular cAMP levels in choroid plexus epithelium, which is known to have regulatory effects on ion and fluid movement in many secretory epithelia. To evaluate whether the hydrocephalus in Tg737 orpk mutants is associated with defects in ion transport, we compared the steady-state pHi and Na+-dependent transport activities of isolated choroid plexus epithelium tissue from Tg737 orpk mutant and wild-type mice. The data indicate that Tg737 orpk mutant choroid plexus epithelium have lower pHi and higher Na+-dependent HCO3− transport activity compared with wild-type choroid plexus epithelium. In addition, wild-type choroid plexus epithelium could be converted to a mutant phenotype with regard to the activity of Na+-dependent HCO3− transport by addition of dibutyryl-cAMP and mutant choroid plexus epithelium toward the wild-type phenotype by inhibiting PKA activity with H-89. Together, these data suggest that cilia have an important role in regulating normal physiology of choroid plexus epithelium and that ciliary dysfunction in Tg737 orpk mutants disrupts a signaling pathway leading to elevated intracellular cAMP levels and aberrant regulation of pHi and ion transport activity.

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