Enantioselective Synthesis of Chiral α-Azido and α-Aryloxy Quaternary Stereogenic Centers via the Phase-Transfer-Catalyzed α-Alkylation of α-Bromomalonates, Followed by SN2 Substitution

2017 ◽  
Vol 82 (9) ◽  
pp. 4936-4943 ◽  
Author(s):  
Doyoung Kim ◽  
Min Woo Ha ◽  
Suckchang Hong ◽  
Cheonhyoung Park ◽  
Byungsoo Kim ◽  
...  
Keyword(s):  
Phase Transfer ◽  
Enantioselective Synthesis ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

Phase-transfer catalyzed enantioselective α-alkylation of α-acyloxymalonates: construction of chiral α-hydroxy quaternary stereogenic centers

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77427-77430 ◽  
Author(s):  
Min Woo Ha ◽  
Sujee Choi ◽  
Seek Kim ◽  
Jun Young Lee ◽  
Jae Kyun Lee ◽  
...  
Keyword(s):  
Natural Products ◽  
Efficient Method ◽  
Phase Transfer ◽  
Enantioselective Synthesis ◽  
Tertiary Alcohols ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

The enantioselective synthesis of α-acyloxy-α-alkylmalonates was developed as an efficient method for producing chiral α-tertiary alcohols, which are potentially valuable intermediates in the synthesis of natural products and pharmaceuticals.

scholarly journals Enantioselective synthesis of gem-diarylalkanes by transition metal-catalyzed asymmetric arylations (TMCAAr)

2018 ◽  
Vol 9 (3) ◽  
pp. 546-559 ◽  
Author(s):  
Tao Jia ◽  
Peng Cao ◽  
Jian Liao
Keyword(s):  
Transition Metal ◽  
Enantioselective Synthesis ◽  
Transfer Reactions ◽  
Stereogenic Centers ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Quaternary Stereogenic Centers ◽  
Aryl Transfer

To date, enantiomerically enriched molecules containing gem(1,1)-diaryl containing tertiary or quaternary stereogenic centers have been readily accessed by transition metal-catalyzed enantioselective or stereoconvergent aryl transfer reactions.

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