Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle

2016 ◽  
Vol 82 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Takashi Hara ◽  
Tetsuya Kodama ◽  
Yumi Takegaki ◽  
Kunihiko Morihiro ◽  
Kosuke Ramon Ito ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Torsion Angle ◽  
Locked Nucleic Acid ◽  
Glycosidic Torsion Angle ◽  
Nucleic Acid Analogues

Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA

2016 ◽  
Vol 14 (6) ◽  
pp. 2034-2040 ◽  
Author(s):  
Robert D. Giacometti ◽  
Juan C. Salinas ◽  
Michael E. Østergaard ◽  
Eric E. Swayze ◽  
Punit P. Seth ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Torsion Angle ◽  
Locked Nucleic Acid ◽  
Design Synthesis ◽  
Conformationally Constrained

The design, synthesis and biophysical evaluation of two highly-constrained tricyclic analogues of locked nucleic acid (LNA), which restrict rotation around torsion angleγare reported.

Synthesis of Functionalized Carbocyclic Locked Nucleic Acid Analogues by Ring-Closing Diene and Enyne Metathesis and Their Influence on Nucleic Acid Stability and Structure

2009 ◽  
Vol 74 (17) ◽  
pp. 6756-6769 ◽  
Author(s):  
Surender Kumar ◽  
Marianne H. Hansen ◽  
Nanna Albæk ◽  
Signe I. Steffansen ◽  
Michael Petersen ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Enyne Metathesis ◽  
Acid Stability ◽  
Nucleic Acid Analogues

Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications

2021 ◽  
Author(s):  
Annamalai Senthilvelan ◽  
Tyson Vonderfecht ◽  
Muthian Shanmugasundaram ◽  
Indra Pal ◽  
Jason Potter ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Acid Moiety ◽  
Therapeutic Applications

Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology

2009 ◽  
Vol 121 (17) ◽  
pp. 3145-3149 ◽  
Author(s):  
Jakob T. Nielsen ◽  
Khalil Arar ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Solution Structure ◽  
Locked Nucleic Acid

i-Motif Formation with Locked Nucleic Acid (LNA)

2007 ◽  
Vol 119 (48) ◽  
pp. 9380-9382 ◽  
Author(s):  
Niti Kumar ◽  
Jakob T. Nielsen ◽  
Souvik Maiti ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid

A Locked Nucleic Acid-Based Nanocrawler: Designed and Reversible Movement Detected by Multicolor Fluorescence

2013 ◽  
Vol 135 (7) ◽  
pp. 2423-2426 ◽  
Author(s):  
I. Kira Astakhova ◽  
Karol Pasternak ◽  
Meghan A. Campbell ◽  
Pankaj Gupta ◽  
Jesper Wengel
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Multicolor Fluorescence
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