Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists

Scott P. Runyon; Chad M. Kormos; Moses G. Gichinga; S. Wayne Mascarella; Hernán A. Navarro; Jeffrey R. Deschamps; Gregory H. Imler; F. Ivy Carroll

doi:10.1021/acs.joc.6b01366

Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists

The Journal of Organic Chemistry ◽

10.1021/acs.joc.6b01366 ◽

2016 ◽

Vol 81 (21) ◽

pp. 10383-10391 ◽

Cited By ~ 5

Author(s):

Scott P. Runyon ◽

Chad M. Kormos ◽

Moses G. Gichinga ◽

S. Wayne Mascarella ◽

Hernán A. Navarro ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Opioid Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127236 ◽

2020 ◽

Vol 30 (13) ◽

pp. 127236

Author(s):

Guangchao He ◽

Qiao Song ◽

Junwei Wang ◽

Anhua Xu ◽

Kewen Peng ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Opioid Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective κ opioid receptor antagonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.02.029 ◽

2017 ◽

Vol 130 ◽

pp. 15-25 ◽

Cited By ~ 9

Author(s):

Junwei Wang ◽

Qiao Song ◽

Anhua Xu ◽

Yu Bao ◽

Yungen Xu ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Opioid Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm061369n ◽

2007 ◽

Vol 50 (12) ◽

pp. 2779-2786 ◽

Cited By ~ 40

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Peg Davis ◽

Shou-wu Ma ◽

Edita Navratilova ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Neurokinin 1 Receptor ◽

Modified Peptides ◽

Μ Opioid Receptor ◽

Neurokinin 1 ◽

Opioid Receptor Agonists ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Synthesis and Biological Evaluation of 14-Alkoxymorphinans. Part 15. Novel δ Opioid Receptor Antagonists with High Affinity and Selectivity in the 14-Alkoxy-Substituted Indolomorphinan Series.

ChemInform ◽

10.1002/chin.199834258 ◽

2010 ◽

Vol 29 (34) ◽

pp. no-no

Author(s):

H. SCHMIDHAMMER ◽

R. KRASSNIG ◽

E. GREINER ◽

J. SCHUETZ ◽

A. WHITE ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

High Affinity ◽

Opioid Receptor Antagonists ◽

Δ Opioid Receptor ◽

Synthesis And Biological Evaluation

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N-(2,7-Dimethyl-2-alkyl-2H-chromen-6-yl)sulfonamide derivatives as selective serotonin 5-HT6 receptor antagonists: design, synthesis, and biological evaluation

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131417 ◽

2021 ◽

pp. 131417

Author(s):

Aizhan Abdildinova ◽

Young Chang Kim ◽

Gee-Hyung Lee ◽

Woo-Kyu Park ◽

Heeyeong Cho ◽

...

Keyword(s):

Biological Evaluation ◽

Selective Serotonin ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.05.002 ◽

2016 ◽

Vol 24 (13) ◽

pp. 2964-2970 ◽

Cited By ~ 7

Author(s):

Ting Guo ◽

Zongjie Gan ◽

Jie Chen ◽

Dechuan Wang ◽

Ling He ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Design Synthesis ◽

Receptor Agonists ◽

Opioid Receptor Agonists ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-019-02291-y ◽

2019 ◽

Vol 28 (3) ◽

pp. 380-386

Author(s):

Junze Dong ◽

Jingya Zhang ◽

Zilu Li ◽

Solomon Asnake ◽

Daoguang Zhang ◽

...

Keyword(s):

Androgen Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Androgen Receptor Antagonists

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Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.09.014 ◽

2018 ◽

Vol 158 ◽

pp. 302-310 ◽

Cited By ~ 4

Author(s):

Jingjing Peng ◽

Lifen Zhao ◽

Lanlan Wang ◽

Hui Chen ◽

Yunguang Qiu ◽

...

Keyword(s):

Biological Evaluation ◽

P2y1 Receptor ◽

Receptor Antagonists ◽

Urea Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.05.078 ◽

2017 ◽

Vol 27 (17) ◽

pp. 4212-4217 ◽

Cited By ~ 2

Author(s):

Kejing Lao ◽

Jie Sun ◽

Chong Wang ◽

Ying Wang ◽

Qidong You ◽

...

Keyword(s):

Androgen Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Amide Derivatives ◽

Synthesis And Biological Evaluation ◽

Androgen Receptor Antagonists

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Design, synthesis, and biological evaluation of benzofuran derivatives as ET receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-013-0542-3 ◽

2013 ◽

Vol 22 (11) ◽

pp. 5472-5480 ◽

Cited By ~ 10

Author(s):

Jin Cai ◽

Junqing Chen ◽

Meng Cao ◽

Peng Wang ◽

Chengliang Feng ◽

...

Keyword(s):

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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