Metal-Free Asymmetric Synthesis of Indanes through Chiral Hypervalent Iodine(III)-Mediated Ring Contraction

2016 ◽  
Vol 81 (5) ◽  
pp. 2174-2181 ◽  
Author(s):  
Anees Ahmad ◽  
Luiz F. Silva
Keyword(s):  
Asymmetric Synthesis ◽  
Hypervalent Iodine ◽  
Ring Contraction ◽  
Metal Free

Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

2019 ◽  
Author(s):  
Arumugavel Murugan ◽  
Venkata Nagarjuna Babu ◽  
Nagaraj Sabarinathan ◽  
Sharada Duddu. S
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Practical Approach ◽  
Hypervalent Iodine ◽  
Radical Mechanism ◽  
Photoredox Catalysis ◽  
Metal Free

Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

Formation of Carbon-Oxygen Bond Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions

2020 ◽  
Vol 17 ◽  
Author(s):  
Ayesha Jalil ◽  
Yaxin O Yang ◽  
Zhendong Chen ◽  
Rongxuan Jia ◽  
Tianhao Bi ◽  
...  
Keyword(s):  
Natural Products ◽  
Bond Formation ◽  
Building Blocks ◽  
Review Article ◽  
Hypervalent Iodine ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
The Past ◽  
Oxygen Bond ◽  
Privileged Scaffolds

: Hypervalent iodine reagents are a class of non-metallic oxidants have been widely used in the construction of several sorts of bond formations. This surging interest in hypervalent iodine reagents is essentially due to their very useful oxidizing properties, combined with their benign environmental character and commercial availability from the past few decades ago. Furthermore, these hypervalent iodine reagents have been used in the construction of many significant building blocks and privileged scaffolds of bioactive natural products. The purpose of writing this review article is to explore all the transformations in which carbon-oxygen bond formation occurred by using hypervalent iodine reagents under metal-free conditions

Synthesis of unsymmetrical phenylurea derivatives via oxidative cross coupling of aryl formamides with amines under metal-free conditions

2015 ◽  
Vol 39 (2) ◽  
pp. 805-809 ◽  
Author(s):  
Nagireddy Veera Reddy ◽  
Pailla Santhosh Kumar ◽  
Peddi Sudhir Reddy ◽  
Mannepalli Lakshmi Kantam ◽  
Kallu Rajender Reddy
Keyword(s):  
Cross Coupling ◽  
Hypervalent Iodine ◽  
Direct Transformation ◽  
Metal Free

A direct transformation of N-aryl formamides to the corresponding phenylurea derivatives via the formation of isocyanate intermediates is achieved in good yields using hypervalent iodine reagents as external oxidants.

Transition‐Metal‐Free Hypervalent Iodine(III) Reagent‐Promoted Site‐Selective Solid‐Phase Synthesis of Mononitroarylamines

2018 ◽  
Vol 3 (45) ◽  
pp. 12946-12950 ◽  
Author(s):  
Delie An ◽  
Wenkang Song ◽  
Zhihong Peng ◽  
Yingjun Zhang ◽  
Wanrong Dong
Keyword(s):  
Transition Metal ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Hypervalent Iodine ◽  
Phase Synthesis ◽  
Metal Free ◽  
Site Selective

scholarly journals Correction: Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones

2017 ◽  
Vol 15 (35) ◽  
pp. 7474-7475 ◽  
Author(s):  
Hasan Mtiraoui ◽  
Kevin Renault ◽  
Morgane Sanselme ◽  
Moncef Msaddek ◽  
Pierre-Yves Renard ◽  
...  
Keyword(s):  
Ring Contraction ◽  
Metal Free

Correction for ‘Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones’ by Hasan Mtiraoui, et al., Org. Biomol. Chem., 2017, 15, 3060–3068.

scholarly journals Catalytic Enantioselective Syn-Hydroxy-Oxyacylation of Electron Deficient Alkenes

2021 ◽  
Author(s):  
Chandra Bhan Pandey ◽  
Vikram Singh ◽  
Susanta Ghanta ◽  
Bhoopendra Twari
Keyword(s):  
Direct Method ◽  
Hypervalent Iodine ◽  
Free Condition ◽  
Metal Free ◽  
A Direct Method

Asymmetric <i>syn</i>-dihydroxylation and dioxyacylation of alkenes have been well established. A direct method for the enantioselective preparation of orthogonally protected <i>syn</i>-1,2-diols from alkenes is unprecedented. Here in, we report the first enantioselective hypervalent iodine catalyzed<i> syn</i>-hydroxy-oxyacylation of enones. The orthogonally protected diols were obtained with excellent diastereo- and regioselectivity under metal-free condition. For these electron-deficient alkenes, even the <i>syn</i>-dihydroxylation and dioxyacylation have remained yet an unfinished challenge.

Hypervalent iodine reagent-mediated reactions involving rearrangement processes

2020 ◽  
Vol 56 (91) ◽  
pp. 14119-14136
Author(s):  
Beibei Zhang ◽  
Xiaoxian Li ◽  
Boying Guo ◽  
Yunfei Du
Keyword(s):  
Claisen Rearrangement ◽  
Beckmann Rearrangement ◽  
Hypervalent Iodine ◽  
Ring Contraction ◽  
Hofmann Rearrangement ◽  
Rearrangement Processes

We summarize the developments of hypervalent iodine reagents-mediated reactions involving [1,2]-migration, Hofmann rearrangement, Beckmann rearrangement, ring contraction/expansion, [3,3]-sigmatropic/iodonium-Claisen rearrangement and some miscellaneous rearrangements.

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