An Enantioselective Approach to Functionalized Amino Acids: Total Synthesis of Antiepileptic Drug (R)-Lacosamide

2015 ◽  
Vol 80 (8) ◽  
pp. 4201-4203 ◽  
Author(s):  
Yuvraj Garg ◽  
Satyendra Kumar Pandey
Keyword(s):  
Amino Acids ◽  
Total Synthesis ◽  
Antiepileptic Drug ◽  
Functionalized Amino Acids

N-Functionalized Amino Acids Promoted Aerobic Copper-Catalyzed Oxidation of Benzylic Alcohols in Water

Synlett ◽  
2015 ◽  
Vol 26 (06) ◽  
pp. 779-784 ◽  
Author(s):  
Chengrong Ding ◽  
Shang Shan ◽  
Guofu Zhang ◽  
Jie Lei ◽  
Xingwang Han ◽  
...  
Keyword(s):  
Amino Acids ◽  
Benzylic Alcohols ◽  
Functionalized Amino Acids ◽  
Catalyzed Oxidation

scholarly journals New cyclization reactions in organic syntheses

2002 ◽  
Vol 74 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Iwao Ojima
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Total Synthesis ◽  
Cyclization Reactions ◽  
Organic Syntheses ◽  
Carbocyclic Compounds ◽  
Efficient Construction ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Recent development in the transition metal-catalyzed cyclization reactions for organic syntheses in the author's laboratories is summarized, which includes (i) novel silylcarbocyclizations (SiCaCs) and carbonylative carbotricyclizations, (ii) intramolecular silylformylations and desymmerization of siloxydiynes by sequential double silylformylation, (iii) efficient total synthesis of (+)-prosopinine, (iv) enantioselective desymmetrization of aminodienes, and (iv) new and efficient routes to 1-azabicyclo[x.y.0]alkane amino acids. All these processes are catalyzed by Rh or Rh­Co complexes, and useful for rapid and efficient construction of a variety of heterocyclic and carbocyclic compounds. Mechanisms of these new carbocyclization and cyclohydrocarbonylation reactions are also discussed.

Synthesis of alkynes and alkynyl iodides bearing a protected amino alcohol moiety as functionalized amino acids precursors

2010 ◽  
Vol 53 (9) ◽  
pp. 1921-1926 ◽  
Author(s):  
Charfedinne Ayed ◽  
Julien Picard ◽  
Nadège Lubin-Germain ◽  
Jacques Uziel ◽  
Jacques Auge
Keyword(s):  
Amino Acids ◽  
Amino Alcohol ◽  
Functionalized Amino Acids ◽  
Alcohol Moiety

Self-Assembling Functionalized Amino Acids into Unusual Shapes

2011 ◽  
Vol 1312 ◽  
Author(s):  
Justin R. Barone ◽  
Naresh K. Budhavaram ◽  
Katherine J. Harvey
Keyword(s):  
Amino Acids ◽  
Hydrogen Bond ◽  
Amino Acid ◽  
Room Temperature ◽  
Vinyl Sulfone ◽  
Ethyl Vinyl ◽  
Simple Route ◽  
Self Assembling ◽  
Component Systems ◽  
Functionalized Amino Acids

ABSTRACTMulti-component small molecule systems that are amphiphilic or that can hydrogen bond end-to-end or side-to-side have been shown to self-assemble into a variety of shapes including fibers, rods, sheets, plates, spheres, and tubes. Recently, we have identified a simple route to self-assemble the same shapes from one-component systems. The structures form by attaching ethyl vinyl sulfone (EVS) to amino acids in water at room temperature. Choice of amino acid, amount of EVS substitution, and solvent conditions determine the final shape. Functionalized amino acids spontaneously form structures like fibers, spheres, tubes, and donuts when dried from solution. Here we focus on fibers and tubes.

ChemInform Abstract: Stereoselective Total Synthesis of Topographically Constrained Designer Amino Acids: 2′,6′-Dimethyl-β-methyltyrosines.

ChemInform ◽  
2010 ◽  
Vol 26 (29) ◽  
pp. no-no
Author(s):  
X. QIAN ◽  
K. C. RUSSELL ◽  
L. W. BOTEJU ◽  
V. J. HRUBY
Keyword(s):  
Amino Acids ◽  
Total Synthesis

Serum Amino Acids, Liver Status, and Antiepileptic Drug Therapy in Epilepsy

Epilepsia ◽  
1993 ◽  
Vol 34 (2) ◽  
pp. 347-354 ◽  
Author(s):  
Marie Luise Rao ◽  
Hermann Stefan ◽  
Christof Scheid ◽  
Anja D. S. Kuttler ◽  
Walter Froscher
Keyword(s):  
Amino Acids ◽  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Serum Amino Acids ◽  
Antiepileptic Drug Therapy
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