scholarly journals Understanding Bond Formation in Polar One-Step Reactions. Topological Analyses of the Reaction between Nitrones and Lithium Ynolates

2015 ◽  
Vol 80 (8) ◽  
pp. 4076-4083 ◽  
Author(s):  
David Roca-López ◽  
Victor Polo ◽  
Tomás Tejero ◽  
Pedro Merino
Keyword(s):  
Bond Formation ◽  
One Step

One Step of Palladium Catalyzed Benzodioxane Ring C—O Bond Formation, Synthesis of Isoamericanol A and Isoamericanin A.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Xiaobi Jing ◽  
Yaocheng Shi ◽  
Yonghong Liu ◽  
Ying Han ◽  
Chaoguo Yan ◽  
...  
Keyword(s):  
Bond Formation ◽  
Palladium Catalyzed ◽  
One Step

scholarly journals One-Step Biocatalytic Synthesis of Sustainable Surfactants Using Selective Amide Bond Formation

2021 ◽  
Author(s):  
Max Lubberink ◽  
Christian Schnepel ◽  
Christopher Baldwin ◽  
Nicholas Turner ◽  
Sabine Flitsch
Keyword(s):  
Fatty Acids ◽  
Carboxylic Acid ◽  
Enzymatic Synthesis ◽  
Bond Formation ◽  
Amide Bond ◽  
Esterification Reaction ◽  
Amide Bond Formation ◽  
Selective Strategy ◽  
One Step ◽  
Acyl Phosphate

N-alkanoyl-N-methylglucamides (MEGAs) are non-toxic surfactants widely used in pharmaceutical and biochemical applications and hence more sustainable syntheses towards these compounds are highly desired. Here we present an aqueous, enzymatic synthesis route towards MEGAs and analogues using carboxylic acid reductase (CAR), which has been engineered to catalyse amide bond formation (CAR-A). Compared to lipase catalysed reactions, this biocatalyst is capable of selective amide bond formation between amino-polyols and fatty acids without the competing esterification reaction being observed. The wide substrate scope of CAR-A catalysed amidation was exemplified by the synthesis of 16 amides including several commercially relevant targets. The ATP co-factor could be recycled from cheap polyphosphate using a kinase. This work establishes acyl-phosphate mediated chemistry as a selective strategy for biocatalytic amide bond formation in the presence of competing alcohol functionalities.

scholarly journals An electron localization function analysis of the molecular mechanism and the C–O bond formation in the [3+2] cycloaddition reaction involving zwitterionic type between a nitrone and an electron deficient ethyne

2019 ◽  
Vol 45 ◽  
pp. 146867831982574
Author(s):  
Abdelilah Benallou ◽  
Habib El Alaoui El Abdallaoui ◽  
Hocine Garmes
Keyword(s):  
Electron Density ◽  
Function Analysis ◽  
Bond Formation ◽  
Cycloaddition Reaction ◽  
Intrinsic Reaction Coordinate ◽  
Dimethyl Acetylenedicarboxylate ◽  
Central Carbon ◽  
One Step ◽  
Free Activation Energy ◽  
Step Mechanism

The mechanistic nature of a [3+2] cycloaddition reaction involving zwitterionic species has been investigated, and the changes of electron density related to the O–C and C–C bond formation along the intrinsic reaction coordinate have been characterized. This polar [3+2] cycloaddition reaction, which takes place through a non-concerted two-stage one-step mechanism, proceeds with a moderate Gibbs free activation energy of 21 kcal mol−1. The reaction begins by the creation of a pseudoradical centre at the central carbon, first on the dimethyl acetylenedicarboxylate, and second on the nitrone framework. This immediately favours the formation of the first O–C single bond by donation of some electron density of the oxygen atom lone pairs, which represents the most attractive centre in this cycloaddition reaction.

One Step of Palladium Catalyzed Benzodioxane Ring C–O Bond Formation, Synthesis of Isoamericanol A and Isoamericanin A

2004 ◽  
Vol 34 (9) ◽  
pp. 1723-1727 ◽  
Author(s):  
Xiaobi Jing ◽  
Yaocheng Shi ◽  
Yonghong Liu ◽  
Ying Han ◽  
Chaoguo Yan ◽  
...  
Keyword(s):  
Bond Formation ◽  
Palladium Catalyzed ◽  
One Step

Highly γ-Regioselective 1,2-Addition of α,β-Unsaturated Oxime Ethers with Allylzinc Bromides: A Straightforward Approach for the Synthesis of Homoallylic Amines

Synthesis ◽  
2019 ◽  
Vol 51 (19) ◽  
pp. 3736-3746
Author(s):  
Bo Yang ◽  
Songlin Zhang
Keyword(s):  
Addition Reaction ◽  
Bond Formation ◽  
High Yield ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Homoallylic Amines ◽  
One Step ◽  
The One ◽  
Straightforward Approach

A highly regioselective reaction between allylzinc bromide reagents and α,β-unsaturated oxime ethers for the one-step synthesis of the homoallylic amines is reported. This process is a regioselective 1,2-addition reaction providing a new γ-position with carbon–carbon bond formation. Furthermore, the reaction substrates are widely applicable and can be produced in a high yield.

Rh(iii)-catalyzed redox-neutral annulation of azo and diazo compounds: one-step access to cinnolines

2016 ◽  
Vol 3 (1) ◽  
pp. 91-95 ◽  
Author(s):  
Peng Sun ◽  
Youzhi Wu ◽  
Yue Huang ◽  
Xiaoming Wu ◽  
Jinyi Xu ◽  
...  
Keyword(s):  
Bond Formation ◽  
Diazo Compounds ◽  
One Step

Cinnolines were synthesized in one step from azo and diazo compounds via a Rh(iii)-catalyzed redox-neutral C–H activation and C–N bond formation strategy.

One-step synthesis of hollow polymeric nanospheres: self-assembly of amphiphilic azo polymers via hydrogen bond formation

RSC Advances ◽  
2014 ◽  
Vol 4 (69) ◽  
pp. 36882-36889 ◽  
Author(s):  
Taoran Zhang ◽  
Cheng Jin ◽  
Lingyu Wang ◽  
Qinjian Yin
Keyword(s):  
Hydrogen Bond ◽  
Self Assembly ◽  
Bond Formation ◽  
Hollow Nanospheres ◽  
Azo Polymers ◽  
Hydrogen Bond Formation ◽  
One Step ◽  
Polymeric Nanospheres

We introduce a facile and novel way that describes the random amphiphilic azo copolymer to construct hollow nanospheres via hydrogen bond formation.

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