Insight into Transannular Cyclization Reactions To Synthesize Azabicyclo[X.Y.Z]alkanone Amino Acid Derivatives from 8-, 9-, and 10-Membered Macrocyclic Dipeptide Lactams

2015 ◽  
Vol 80 (10) ◽  
pp. 4904-4918 ◽  
Author(s):  
N. D. Prasad Atmuri ◽  
William D. Lubell
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Cyclization Reactions ◽  
Transannular Cyclization ◽  
Insight Into

Complexation of Fluorinated Amino Acid Derivatives by β- and γ-Cyclodextrin in Aqueous Solution. A 19F Nuclear Magnetic Resonance Study

1995 ◽  
Vol 48 (3) ◽  
pp. 505 ◽  
Author(s):  
SE Brown ◽  
CJ Easton ◽  
SF Lincoln
Keyword(s):  
Aqueous Solution ◽  
Amino Acid ◽  
Nuclear Magnetic Resonance Study ◽  
Amino Acid Derivatives ◽  
Magnetic Resonance Study ◽  
Cyclodextrin Complexes ◽  
Factors Affecting ◽  
Chemical Shift Data ◽  
Shift Data ◽  
Insight Into

A 19F n.m.r. study shows that the β-cyclodextrin complexes of deprotonated α-(p- fluorophenyl ) glycine, N-acetyl-α-(p- fluorophenyl ) glycine , deprotonated N-acetyl-α-(p- fluorophenyl ) glycine , and N-(p- fluorobenzoyl ) valine are characterized by stability constants KR/dm3 mol-1 and Ks/dm3 mol-1 =13�2 and 21�3, 34�1 and 35�2, 12�1 and 12� 1, and 84�2 and 93�2, respectively, where the first and second of each pair of values refers to the complex formed by the R and S enantiomers of the fluorinated amino acid derivatives, respectively, in 10% aqueous D2O solution at 295.5 K and I = 0.10 mol dm-3. A comparison of these data and the associated 19F chemical shift data with those for the analogous α- and γ- cyclodextrin complexes provides an insight into the factors affecting the stabilities and structures of these complexes.

An insight into the synthesis of novel aryl-substituted alicyclic β-amino acid derivatives through substrate-directed palladium-catalysed regio- and stereoselective cross-coupling

RSC Advances ◽  
2015 ◽  
Vol 5 (18) ◽  
pp. 13628-13634 ◽  
Author(s):  
Melinda Nonn ◽  
Loránd Kiss ◽  
Mikko M. Hänninen ◽  
Ferenc Fülöp
Keyword(s):  
Amino Acid ◽  
Cross Coupling ◽  
Amino Acid Derivatives ◽  
Amino Esters ◽  
Aryl Iodides ◽  
Insight Into

Novel aryl-substituted alicyclic β-amino acid derivatives were synthesized through substrate-determined palladium-catalysed cross-coupling of aryl iodides with five- or six-membered cycloalkene β-amino esters.

Intramolecular Ester Enolate–Imine Cyclization Reactions for the Asymmetric Synthesis of Polycyclic β-Lactams and Cyclic β-Amino Acid Derivatives

2011 ◽  
Vol 13 (23) ◽  
pp. 6276-6279 ◽  
Author(s):  
Caroline D. Evans ◽  
Mary F. Mahon ◽  
Philip C. Andrews ◽  
James Muir ◽  
Steven D. Bull
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Amino Acid Derivatives ◽  
Cyclization Reactions ◽  
Ester Enolate

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of
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