Copper-Catalyzed Conjugate Additions to Isocyanoalkenes

2021 ◽  
Author(s):  
John-Paul R. Marrazzo ◽  
Allen Chao ◽  
Yajun Li ◽  
Fraser F. Fleming
Keyword(s):  
Conjugate Additions

Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules

2016 ◽  
Vol 21 (3) ◽  
pp. 190-217 ◽  
Author(s):  
Paola Vitale ◽  
Vito Capriati ◽  
Saverio Florio ◽  
Filippo Perna ◽  
Antonio Salomone
Keyword(s):  
Conjugate Additions ◽  
Complex Molecules

Synthetic Strategies to Access Heteroatomic Spirocentres Embedded in Natural Products

Synthesis ◽  
2021 ◽  
Author(s):  
Michael P. Badart ◽  
Bill C. Hawkins
Keyword(s):  
Natural Products ◽  
Heterocyclic Compound ◽  
Chemical Space ◽  
Three Dimensional ◽  
Coupling Reactions ◽  
Conjugate Additions ◽  
Biological Targets ◽  
Compound Libraries ◽  
The Common ◽  
Significant Attention

AbstractThe spirocyclic motif is abundant in natural products and provides an ideal three-dimensional template to interact with biological targets. With significant attention historically expended on the synthesis of flat-heterocyclic compound libraries, methods to access the less-explored three-dimensional medicinal-chemical space will continue to increase in demand. Herein, we highlight by reaction class the common strategies used to construct the spirocyclic centres embedded in a series of well-studied natural products.1 Introduction2 Cycloadditions3 Palladium-Catalysed Coupling Reactions4 Conjugate Additions5 Imines, Aminals, and Hemiaminal Ethers6 Mannich-Type Reactions7 Oxidative Dearomatisation8 Alkylation9 Organometallic Additions10 Conclusions

scholarly journals Catalytic Conjugate Additions of Carbonyl Anions under Neutral Aqueous Conditions.

ChemInform ◽  
2006 ◽  
Vol 37 (9) ◽  
Author(s):  
Michael C. Myers ◽  
Ashwin R. Bharadwaj ◽  
Benjamin C. Milgram ◽  
Karl A. Scheidt
Keyword(s):  
Conjugate Additions ◽  
Aqueous Conditions

Conjugate Additions of Secondary Amines and Water to Allenyl Perfluoroalkyl Sulfones

2006 ◽  
Vol 24 (6) ◽  
pp. 775-780 ◽  
Author(s):  
Xiao-Jin Wang ◽  
Yun Lin ◽  
Jin-Tao Liu
Keyword(s):  
Secondary Amines ◽  
Conjugate Additions

Conjugate Additions to Vinyl-Substituted Aromatic N-Heterocycles

Synlett ◽  
2012 ◽  
Vol 23 (11) ◽  
pp. 1590-1604 ◽  
Author(s):  
Douglas Klumpp
Keyword(s):  
Conjugate Additions

ChemInform Abstract: THE ROLE OF SOLVENT IN CONJUGATE ADDITIONS LEADING TO CIS- AND TRANS-1-ALKYL-2-ARYL-3-CARBO(AROYL)AZIRIDINES

1977 ◽  
Vol 8 (40) ◽  
pp. no-no
Author(s):  
P. TARBURTON ◽  
P. B. WOLLER ◽  
R. C. BADGER ◽  
E. DOOMES ◽  
N. H. CROMWELL
Keyword(s):  
Conjugate Additions ◽  
Cis And Trans ◽  
Role Of Solvent

Asymmetric conjugate additions of 2-substituted benzofuran-3(2H)-ones to α,β-unsaturated ketones catalyzed by chiral copper complexes

2017 ◽  
Vol 15 (19) ◽  
pp. 4191-4198 ◽  
Author(s):  
Haojiang Wang ◽  
Yifeng Wang ◽  
Cheng Zhang ◽  
Yidong Jiang ◽  
Mingming Chu ◽  
...  
Keyword(s):  
Copper Complexes ◽  
Conjugate Addition ◽  
Conjugate Additions ◽  
Unsaturated Ketones

A highly enantioselective conjugate addition of 2-substituted benzofuran-3(2H)-ones to α,β-unsaturated ketones promoted by chiral copper complexes has been developed.

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