Synthesis of N-Boc-α-amino Acids from Carbon Dioxide by Electrochemical Carboxylation of N-Boc-α-aminosulfones

2021 ◽  
Author(s):  
Hisanori Senboku ◽  
Yoshihito Minemura ◽  
Yuto Suzuki ◽  
Hidetoshi Matsuno ◽  
Mayu Takakuwa
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Electrochemical Carboxylation

Adsorption of carbon dioxide on naturally occurring solid amino acids

2016 ◽  
Vol 4 (3) ◽  
pp. 3170-3176 ◽  
Author(s):  
Sreedipta Chatterjee ◽  
Sadhana Rayalu ◽  
Spas D. Kolev ◽  
Reddithota J. Krupadam
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Naturally Occurring

COMPETITION BETWEEN AMINO ACIDS FOR TRANSPORT INTO EHRLICH ASCITES CARCINOMA CELLS

1961 ◽  
Vol 39 (11) ◽  
pp. 1717-1735 ◽  
Author(s):  
P. G. Scholefield
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Amino Acid ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Transport Systems ◽  
Radioactive Carbon ◽  
Ehrlich Ascites ◽  
Competitive Inhibitors ◽  
Amino Acid Analogues

The cumulative entry of amino acids into Ehrlich ascites carcinoma cells is due to the presence of active transport systems, each with its own specific range of substrates. Several amino acids and amino acid analogues may have an affinity for the same transport system and thus may inhibit transport of other amino acids by acting as competitive inhibitors or competitive substrates. Loss of methionine from ascites cells takes place by a diffusion process which obeys Fick's law. Leucine accumulation by ascites cells is small and is increased on addition of certain other amino acids. The increase is not due to inhibition of leucine oxidation as increase in the rate of production of radioactive carbon dioxide from labeled leucine also occurs. Kinetic aspects of these results are discussed.

scholarly journals Direct Electrochemical Carboxylation of Benzylic C–N Bonds with Carbon Dioxide

ACS Catalysis ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 4699-4705 ◽  
Author(s):  
Deng-Tao Yang ◽  
Minghui Zhu ◽  
Zachary J. Schiffer ◽  
Kindle Williams ◽  
Xiaojie Song ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Electrochemical Carboxylation

scholarly journals Nickel-Catalyzed β-Carboxylation of Ynamides with Carbon Dioxide

Synlett ◽  
2019 ◽  
Vol 30 (09) ◽  
pp. 1048-1052 ◽  
Author(s):  
Ryohei Doi ◽  
Taichi Okano ◽  
Iman Abdullah ◽  
Yoshihiro Sato
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Magnesium Salt ◽  
Reaction Efficiency

A nickel-catalyzed β-selective hydrocarboxylation of ynamides to give protected dehydro-β-amino acids was developed. The key to exclusive β-selectivity was the use of diethylzinc as a reductant in the presence of a magnesium salt. The reaction was conducted with bis(acetylacetonato)nickel(II) instead of costly and sensitive bis(1,5-cyclooctadiene)nickel(0). In addition, the optimized ligand was inexpensive 1,5-cyclooctadiene. Investigation of the substrate scope revealed that both nitrogen and alkyne substituents have marked effects on the reaction efficiency. We obtained experimental clues that indicated the formation of a vinylzinc intermediate that forms a C–C bond with CO2.

Derivatization of Chiral Amino Acids in Supercritical Carbon Dioxide

2004 ◽  
Vol 76 (3) ◽  
pp. 736-741 ◽  
Author(s):  
María del Mar Caja López ◽  
Gracia P. Blanch ◽  
Marta Herraiz
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Supercritical Carbon Dioxide ◽  
Chiral Amino Acids ◽  
Supercritical Carbon

THE ESTIMATION OF FREE AMINO ACIDS USING A MICRODIFFUSION TECHNIQUE

1952 ◽  
Vol 30 (7) ◽  
pp. 522-528 ◽  
Author(s):  
W. B. McConnell
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
The Other ◽  
Routine Analysis ◽  
Average Deviation ◽  
Substantial Saving ◽  
Ionic Concentrations ◽  
The Mean

The carbon dioxide evolved when α-amino acids were heated for one hour at 85 °C. with ninhydrin was determined in a partially evacuated microdiffusion cell. Distillation of solvent from one chamber to the other was minimized by keeping the ionic concentrations of the reaction mixture and absorbing mixture approximately equal. The method was useful for samples of amino acids which liberated from 0.06 to 0.3 mgm. of carbon dioxide. The average deviation from the mean was somewhat less than 1% for samples liberating 0.2 mgm. of carbon dioxide. Use of the method for routine analysis of enzymatic digests resulted in substantial saving of time and material.

THE METABOLISM OF PROPIONATE BY WHEAT STEM RUST UREDOSPORES

1963 ◽  
Vol 41 (3) ◽  
pp. 737-743 ◽  
Author(s):  
H. Reisener ◽  
A. J. Finlayson ◽  
W. B. McConnell ◽  
G. A. Ledingham
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Glutamic Acid ◽  
Stem Rust ◽  
Water Extract ◽  
Hot Water ◽  
Insoluble Residue ◽  
Soluble Carbohydrates ◽  
Wheat Stem Rust ◽  
Carbon 14

When uredospores of wheat stem rust were shaken for 3 hours with phosphate buffer (pH 6.2) containing propionate-1-C14, -2-C14, or -3-C14, about 55% of the carbon-14 was removed from the solution. With propionate-1-C14, most of the carbon-14 taken up was released as carbon dioxide-C14, whereas about 20% and 31% of propionate carbon 2 and carbon 3, respectively, was incorporated into the spores. The specific activity of a fraction consisting of the free amino acids of a hot-alcohol and hot-water extract of the spores increased markedly with increase in the position number of propionate in which the carbon-14 was located. A similar relation was observed for other fractions such as soluble carbohydrates, ether-soluble material, organic acids, and insoluble residue from spores. The most active amino acids isolated were glutamic acid, γ-aminobutyric acid, and alanine. Partial degradations showed that with propionate-2-C14 the carboxyl groups of glutamic acid were especially radioactive, whereas with propionate-3-C14 the internal carbons were most radioactive.It is concluded that propionate metabolism in the rust spores involved conversion of carbon 1 to carbon dioxide, and utilization of carbons 2 and 3 as acetate with carbon 2 behaving as the carboxyl carbon.

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