Synthesis and Spectroscopic Properties of 1,2,3-Triazole BOPAHY Dyes and Their Water-Soluble Triazolium Salts

2021 ◽  
Author(s):  
Tomas Horsten ◽  
Flip de Jong ◽  
Dries Theunissen ◽  
Mark Van der Auweraer ◽  
Wim Dehaen
Keyword(s):  
Spectroscopic Properties ◽  
Water Soluble ◽  
Triazolium Salts

scholarly journals Soluble Cyanobacterial Carotenoprotein as a Robust Antioxidant Nanocarrier and Delivery Module

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 869
Author(s):  
Eugene G. Maksimov ◽  
Alexey V. Zamaraev ◽  
Evgenia Yu. Parshina ◽  
Yury B. Slonimskiy ◽  
Tatiana A. Slastnikova ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Protein Complexes ◽  
Neuroblastoma Cell ◽  
Spectroscopic Properties ◽  
Neuroblastoma Cell Line ◽  
Water Soluble ◽  
Modular Systems ◽  
Pigment Protein Complexes ◽  
Anabaena Sp ◽  
Pcc 7120

To counteract oxidative stress, antioxidants including carotenoids are highly promising, yet their exploitation is drastically limited by the poor bioavailability and fast photodestruction, whereas current delivery systems are far from being efficient. Here we demonstrate that the recently discovered nanometer-sized water-soluble carotenoprotein from Anabaena sp. PCC 7120 (termed AnaCTDH) transiently interacts with liposomes to efficiently extract carotenoids via carotenoid-mediated homodimerization, yielding violet–purple protein samples. We characterize the spectroscopic properties of the obtained pigment–protein complexes and the thermodynamics of liposome–protein carotenoid transfer and demonstrate the delivery of carotenoid echinenone from AnaCTDH into liposomes with an efficiency of up to 70 ± 3%. Most importantly, we show efficient carotenoid delivery to membranes of mammalian cells, which provides protection from reactive oxygen species (ROS). Incubation of neuroblastoma cell line Tet21N in the presence of 1 μM AnaCTDH binding echinenone decreased antimycin A ROS production by 25% (p < 0.05). The described carotenoprotein may be considered as part of modular systems for the targeted antioxidant delivery.

Synthesis and spectroscopic properties of a series of octacationic water-soluble phthalocyanines

2011 ◽  
Vol 161 (11-12) ◽  
pp. 943-948 ◽  
Author(s):  
Zekeriya Bıyıklıoğlu ◽  
Halit Kantekin
Keyword(s):  
Spectroscopic Properties ◽  
Water Soluble

Spectroscopic Properties, Excitation, and Electron Transfer in an Anionic Water-Soluble Poly(fluorene-alt-phenylene)-perylenediimide Copolymer

2012 ◽  
Vol 116 (25) ◽  
pp. 7548-7559 ◽  
Author(s):  
Ana T. Marques ◽  
Hugh D. Burrows ◽  
J. Sérgio Seixas de Melo ◽  
Artur J. M. Valente ◽  
Licínia L. G. Justino ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Spectroscopic Properties ◽  
Water Soluble ◽  
Soluble Poly

scholarly journals Soluble cyanobacterial carotenoprotein as a robust antioxidant nanocarrier and delivery module

2019 ◽  
Author(s):  
Eugene G. Maksimov ◽  
Alexey V. Zamaraev ◽  
Evgenia Yu. Parshina ◽  
Yury B. Slonimskiy ◽  
Tatiana A. Slastnikova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Targeted Delivery ◽  
Mammalian Cells ◽  
Protein Complexes ◽  
Natural Antioxidants ◽  
Spectroscopic Properties ◽  
Water Soluble ◽  
Modular Systems ◽  
Long Term Storage ◽  
Pigment Protein Complexes

AbstractTo counteract oxidative stress, antioxidants including carotenoids are highly promising, yet their exploitation is drastically limited by the poor bioavailability and fast photodestruction, whereas current delivery systems are far from being efficient. Here we demonstrate that the recently discovered nanometer-sized water-soluble carotenoprotein from Anabaena (termed CTDH) transiently interacts with liposomes to efficiently extract carotenoids via carotenoid-mediated homodimerization, yielding violet-purple protein samples amenable to lyophilization and long-term storage. We characterize spectroscopic properties of the pigment-protein complexes and thermodynamics of liposome-protein carotenoid transfer and demonstrate the highly efficient delivery of echinenone form CTDH into liposomes. Most importantly, we show carotenoid delivery to membranes of mammalian cells, which provides protection from reactive oxygen species. The described carotenoprotein may be considered as part of modular systems for the targeted antioxidant delivery.Significance statementCarotenoids are excellent natural antioxidants but their delivery to vulnerable cells is challenging due to their hydrophobic nature and susceptibility to degradation. Thus, systems securing antioxidant stability and facilitating targeted delivery are of great interest for the design of medical agents. In this work, we have demonstrated that soluble cyanobacterial carotenoprotein can deliver echinenone into membranes of liposomes and mammalian cells with almost 70 % efficiency, which alleviates the induced oxidative stress. Our findings warrant the robustness of the protein-based carotenoid delivery for studies of carotenoid activities and effects on cell models.

scholarly journals Synthesis and Spectral Studies of Some Zn(II) Complexes with Substituted N,N-Donor Ligands Derived from Pyridine-2-carbaldehyde

2019 ◽  
Vol 32 (1) ◽  
pp. 122-126 ◽  
Author(s):  
Shiva Lall Sunar ◽  
Keisham Surjit Singh ◽  
Sajal Kundu
Keyword(s):  
Crystal Structure ◽  
Spectral Analysis ◽  
Emission Spectra ◽  
Spectroscopic Properties ◽  
Octahedral Geometry ◽  
Water Soluble ◽  
Donor Ligands ◽  
Spectral Studies ◽  
X Ray ◽  
Uv Visible

A series of four neutral zinc complexes with substituted N,N-donor ligands viz. Ln = (E)-N-(pyridin-2-ylmethylene)anilines of composition [Zn(NO3)2(L1)] (1), [Zn(NO3)2L2] (2), [Zn(NO3)2L3] (3), [Zn(NO3)2L4] (4) were synthesized and characterized. The spectroscopic properties of the Zn(II) complexes were studied by UV-visible, fluorescence, IR and 1H NMR spectral analysis. All the zinc(II) complexes are water soluble and non-electrolyte in solution. Efforts for getting single crystals suitable for X-ray crystal structure could not be achieved. However, on the basis of spectral studies, compounds 1-4 are proposed to have octahedral geometry. The emission spectra of all the complexes show π-π* (intra-ligand) transition.

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