Base-Catalyzed Three-Component Reaction of α-Cyanoacetates with Chalcones and Elemental Sulfur: Access to 2-Aminothiophenes Unobtainable via the Gewald Reaction

2021 ◽  
Author(s):  
Thanh Binh Nguyen ◽  
Dinh Hung Mac ◽  
Pascal Retailleau
Keyword(s):  
Elemental Sulfur ◽  
Three Component Reaction ◽  
Gewald Reaction

scholarly journals A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates

2019 ◽  
Vol 15 ◽  
pp. 1523-1533 ◽  
Author(s):  
András György Németh ◽  
György Miklós Keserű ◽  
Péter Ábrányi-Balogh
Keyword(s):  
Elemental Sulfur ◽  
Building Blocks ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
Synthetic Procedure ◽  
Three Component Reaction ◽  
Wide Range ◽  
Organic Chemist ◽  
The One

A new multicomponent reaction has been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O-thiocarbamates and dithiocarbamates in moderate to good yields. The one-pot reaction cascade involves the formation of an isothiocyanate intermediate, thus a catalyst-free synthesis of isothiocyanates, as valuable building blocks from isocyanides and sulfur is proposed, as well. The synthetic procedure suits the demand of a modern organic chemist, as it tolerates a wide range of functional groups, it is atom economic and easily scalable.

Activation of Elemental Sulfur by Electrogenerated Cyanomethyl Anion: Synthesis of Substituted 2-Aminothiophenes by the Gewald Reaction

2008 ◽  
Vol 350 (17) ◽  
pp. 2740-2746 ◽  
Author(s):  
Marta Feroci ◽  
Isabella Chiarotto ◽  
Leucio Rossi ◽  
Achille Inesi
Keyword(s):  
Elemental Sulfur ◽  
Gewald Reaction

Three-component reaction between elemental sulfur, primary phosphines, and amines: straightforward synthesis of organylammonium trithiophosphonates

2012 ◽  
Vol 34 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Alexander V. Artem'ev ◽  
Svetlana F. Malysheva ◽  
Nataliya A. Belogorlova ◽  
Nina K. Gusarova
Keyword(s):  
Elemental Sulfur ◽  
Three Component Reaction
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