[(PPh3)2NiCl2]-Catalyzed C–N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines

2021 ◽  
Author(s):  
S. N. R. Donthireddy ◽  
Vipin K. Pandey ◽  
Arnab Rit
Keyword(s):  
Bond Formation ◽  
Secondary Amines ◽  
Formation Reaction ◽  
Borrowing Hydrogen

scholarly journals Kinetic resolution of indolines by asymmetric hydroxylamine formation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Gang Wang ◽  
Ran Lu ◽  
Chuangchuang He ◽  
Lei Liu
Keyword(s):  
Hydrogen Peroxide ◽  
Chemical Synthesis ◽  
Late Stage ◽  
Kinetic Resolution ◽  
High Efficiency ◽  
Bond Formation ◽  
Bioactive Molecules ◽  
Environmentally Benign ◽  
Secondary Amines

AbstractCatalytic kinetic resolution of amines represents a longstanding challenge in chemical synthesis. Here, we described a kinetic resolution of secondary amines through oxygenation to produce enantiopure hydroxylamines involving N–O bond formation. The economic and practical titanium-catalyzed asymmetric oxygenation with environmentally benign hydrogen peroxide as oxidant is applicable to a range of racemic indolines with multiple stereocenters and diverse substituent patterns in high efficiency with efficient chemoselectivity and enantio-discrimination. Late-stage asymmetric oxygenation of bioactive molecules that are otherwise difficult to synthesize was also explored.

Sunlight-induced C C bond formation reaction: Radical addition of alcohols/ethers/acetals to olefins

2021 ◽  
Vol 413 ◽  
pp. 113263
Author(s):  
Mamiko Hayakawa ◽  
Hisashi Shirota ◽  
Souta Hirayama ◽  
Ryuusei Yamada ◽  
Tadashi Aoyama ◽  
...  
Keyword(s):  
Bond Formation ◽  
Radical Addition ◽  
Formation Reaction

Iron‐Catalyzed N‐Alkylation of Secondary Amines with Alcohols Using Borrowing Hydrogen Strategy

2021 ◽  
Vol 6 (17) ◽  
pp. 4089-4097
Author(s):  
Ruxin Qu ◽  
Yaxuan Cheng ◽  
Siwei Yang ◽  
Chaoyu Zhao ◽  
Huiling Liu ◽  
...  
Keyword(s):  
Secondary Amines ◽  
Borrowing Hydrogen

ChemInform Abstract: Borrowing Hydrogen. C-N Bond Formation from Alcohols

ChemInform ◽  
2009 ◽  
Vol 40 (35) ◽  
Author(s):  
G. W. Lamb ◽  
J. M. J. Williams
Keyword(s):  
Bond Formation ◽  
Borrowing Hydrogen

scholarly journals Iodobenzene-Promoted Pd-Catalysed ortho-Directed C–H Activation: The Synthesis of Benzothiazoles via Intramolecular Coupling

SynOpen ◽  
2017 ◽  
Vol 01 (01) ◽  
pp. 0001-0007 ◽  
Author(s):  
Meng-Tian Zeng ◽  
Wan Xu ◽  
Min Liu ◽  
Xing Liu ◽  
Cai-Zhu Chang ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Bond Formation ◽  
Formation Reaction ◽  
Aryl Ring ◽  
Thiourea Group

A series of 2-aminobenzothiazoles were synthesized by a palladium-catalysed oxidative coupling with good yields (62–89%). Iodobenzene was found to be effective as an additive in this intramolecular C–S bond-formation reaction. The directing thiourea group attached to the aryl ring is essential for the activation of the ortho C–H bond.

Novel carbon-carbon bond formation reaction at the C-4 position of an azetidin-2-one by means of radical cyclization

1988 ◽  
Vol 53 (12) ◽  
pp. 2683-2687 ◽  
Author(s):  
Tetsuji Kametani ◽  
Shih Der Chu ◽  
Akira Itoh ◽  
Sayuri Maeda ◽  
Toshio Honda
Keyword(s):  
Bond Formation ◽  
Radical Cyclization ◽  
Formation Reaction ◽  
Carbon Bond ◽  
Carbon Carbon Bond
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