scholarly journals A Stereoselective aza-Prins Reaction: Rapid Access to Enantiopure Piperidines and Pipecolic Acids

2021 ◽  
Vol 86 (3) ◽  
pp. 2076-2089
Author(s):  
Ramana Reddy Mittapalli ◽  
Simon J. Coles ◽  
Wim T. Klooster ◽  
Adrian P. Dobbs
Keyword(s):  
Prins Reaction ◽  
Rapid Access

Cascade CuH-Catalyzed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products

2019 ◽  
Author(s):  
De-Wei Gao ◽  
Yang Gao ◽  
Huiling Shao ◽  
Tian-Zhang Qiao ◽  
Xin Wang ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Proteasome Inhibitors ◽  
Building Blocks ◽  
Unique Role ◽  
Efficient Strategy ◽  
Carbon Centers ◽  
Rapid Access ◽  
Cascade Catalysis ◽  
Privileged Scaffolds

Enantioenriched <i>α</i>-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharmacophores in proteasome inhibitors. Additionally, they represent synthetically useful chiral building blocks in organic synthesis. Recently, CuH-catalyzed asymmetric alkene hydrofunctionalization has become a powerful tool to construct stereogenic carbon centers. In contrast, applying CuH cascade catalysis to achieve reductive 1,1-difunctionalization of alkynes remains an important, but largely unaddressed, synthetic challenge. Herein, we report an efficient strategy to synthesize <i>α</i>-aminoboronates <i>via </i>CuH-catalyzed hydroboration/hydroamination cascade of readily available alkynes. Notably, this transformation selectively delivers the desired 1,1-heterodifunctionalized product in favor of alternative homodifunctionalized, 1,2-heterodifunctionalized, or reductively monofunctionalized byproducts, thereby offering rapid access to these privileged scaffolds with high chemo-, regio- and enantioselectivity.<br>

Rapid Access of New Pyranocarbazole Derivatives Under Microwave Irradiation

2019 ◽  
Vol 5 (2) ◽  
pp. 104-110
Author(s):  
Pedavenkatagari N. Reddy ◽  
Pannala Padmaja
Keyword(s):  
Microwave Irradiation ◽  
Rapid Access

155 Evaluation of the Rapid Access Chest Pain Clinic Service

Heart ◽  
2015 ◽  
Vol 101 (Suppl 4) ◽  
pp. A89.1-A89
Author(s):  
Ho Tin Wong ◽  
Alexander Daniel Simms ◽  
Mirza Wazir Baig ◽  
Klaus Karl Witte
Keyword(s):  
Chest Pain ◽  
Pain Clinic ◽  
Rapid Access

A brief report on rapid access to medication assisted treatment

2021 ◽  
pp. 1-8
Author(s):  
Daniel Baslock ◽  
Barbara Gramuglia ◽  
Alice Spirito ◽  
Javad Mashkuri ◽  
Victoria Stanhope
Keyword(s):  
Medication Assisted Treatment ◽  
Rapid Access

Visible-light-induced remote C(sp3)-H sulfonylvinylation: assembly of cyanoalkylated vinyl sulfones

2021 ◽  
Author(s):  
Ping Bao ◽  
Feiyan Yu ◽  
Fu-Sheng He ◽  
Zhimei Tang ◽  
Wei-Ping Deng ◽  
...  
Keyword(s):  
Visible Light ◽  
Rapid Access ◽  
Three Component Reaction ◽  
Propargyl Alcohols

A photoinduced sulfonylvinylation of unactivated C(sp3)-H bond through a three-component reaction of propargyl alcohols, potassium metabisulfite and cycloketone oxime esters is developed. This approach enables rapid access to cyanoalkylated vinyl...

scholarly journals “I’m truly free from my eating disorder”: Emerging adults’ experiences of FREED, an early intervention service model and care pathway for eating disorders

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Rachel Potterton ◽  
Amelia Austin ◽  
Michaela Flynn ◽  
Karina Allen ◽  
Vanessa Lawrence ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Eating Disorder ◽  
Early Intervention ◽  
Emerging Adults ◽  
Care Pathway ◽  
Support Network ◽  
First Episode ◽  
Service Model ◽  
Access To Treatment ◽  
Rapid Access

Abstract Background Eating disorders (EDs) typically start during adolescence or emerging adulthood, periods of intense biopsychosocial development. FREED (First Episode Rapid Early Intervention for EDs) is a service model and care pathway providing rapid access to developmentally-informed care for emerging adults with EDs. FREED is associated with reduced duration of untreated eating disorder and improved clinical outcomes, but patients’ experiences of treatment have yet to be assessed. Objective This study aimed to assess emerging adults’ experiences of receiving treatment through FREED. Method This study triangulated qualitative data on participants’ experiences of FREED treatment from questionnaires and semi-structured interviews. Participants were 106 emerging adults (aged 16–25; illness duration < 3 yrs) (questionnaire only = 92; interview only = 6; both = 8). Data were analysed thematically. Results Most participants reported psychological and behavioural changes over the course of treatment (e.g. reduction in symptoms; increased acceptance and understanding of difficulties). Participants identified five beneficial characteristics of FREED treatment: i) rapid access to treatment; ii) knowledgeable and concerned clinicians; iii) focusing on life beyond the eating disorder; iv) building a support network; v) becoming your own therapist. Conclusion This study provides further supports for the implementation of early intervention and developmentally-informed care for EDs. Future service model development should include efforts to increase early help-seeking.

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