tert-Amino Effect-Promoted Rearrangement of Aryl Isothiocyanate: A Versatile Approach to Benzimidazothiazepines and Benzimidazothioethers

2020 ◽  
Vol 85 (19) ◽  
pp. 12635-12643
Author(s):  
Xinyu Geng ◽  
Siyuan Liu ◽  
Wenyao Wang ◽  
Jingping Qu ◽  
Baomin Wang
Keyword(s):  
Aryl Isothiocyanate

scholarly journals Reactions of 3-Phenyl-8-triphenylphosphoimino-1-azaazulene with Aryl Isocyanate, Aryl Isothiocyanate, and Carbon Disulfide

Heterocycles ◽  
2004 ◽  
Vol 64 (1) ◽  
pp. 291 ◽  
Author(s):  
Noritaka Abe ◽  
Kentaro Nagamatsu ◽  
Hiroyuki Fujii ◽  
Akikazu Kakehi
Keyword(s):  
Carbon Disulfide ◽  
Aryl Isothiocyanate

scholarly journals Reactions of 3-Phenyl-8-triphenylphosphoimino-1-azaazulene with Aryl Isocyanate, Aryl Isothiocyanate, and Carbon Disulfide.

ChemInform ◽  
2005 ◽  
Vol 36 (25) ◽  
Author(s):  
Kentaro Nagamatsu ◽  
Hiroyuki Fujii ◽  
Noritaka Abe ◽  
Akikazu Kakehi
Keyword(s):  
Carbon Disulfide ◽  
Aryl Isothiocyanate

scholarly journals Facile Synthesis, Characterization and Antimicrobial Activities of Novel 6-AminoTriazolo-Thiadiazoles Integrated with Benzofuran and Pyrazole Moieties

2019 ◽  
Vol 35 (6) ◽  
pp. 1712-1717
Author(s):  
Mohammad Idrees ◽  
Satish S. Kola ◽  
Naqui J. Siddiqui
Keyword(s):  
Mass Spectra ◽  
Antimicrobial Activities ◽  
Bacterial Strains ◽  
Facile Synthesis ◽  
One Pot ◽  
Standard Drug ◽  
Cyclocondensation Reaction ◽  
Aryl Isothiocyanate ◽  
Work Up

In the undertaken research we have reported simple efficient technique to afford a novel series of 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-N-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (4a-g) derivatives obtained by one pot cyclocondensation reaction of 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-4-amino-4H-1,2,4-triazole-3-thiol (3) with substituted aryl isothiocyanate in DMF and K2CO3, without formation undesirable side products by simple work up procedure. The structures yielded (4a-g) were established by 13CNMR, IR, 1HNMR, elemental analysis and mass spectra. Entire synthesised compounds were screened for their in-vitro biological assay via microorganism Gram positive and Gram negative bacterial strains at different concentrations. The bioassay revealed that some of the compounds have promising antimicrobial activities when compared with standard drug Chloramphenicol.

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