scholarly journals Evaluation of Inhibitory Activities of UK-2A, an Antimycin-Type Antibiotic, and Its Synthetic Analogues against the Production of Anti-inflammatory Cytokine IL-4

2018 ◽  
Vol 81 (11) ◽  
pp. 2590-2594 ◽  
Author(s):  
Yoshinosuke Usuki ◽  
Saho Ishii ◽  
Minako Ijiri ◽  
Ken-Ichi Yoshida ◽  
Tetsuya Satoh ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Synthetic Analogues ◽  
Inhibitory Activities ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Regulation by anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGFβ)of interleukin-8 production by LPS- and/ or TNFα-activated human polymorphonuclear cells

1996 ◽  
Vol 5 (5) ◽  
pp. 334-340 ◽  
Author(s):  
C. Marie ◽  
C. Pitton ◽  
C. Fitting ◽  
J-M. Cavaillon
Keyword(s):  
Inflammatory Cytokine ◽  
Transcriptional Level ◽  
Polymorphonuclear Cells ◽  
Inhibitory Effects ◽  
Whole Blood Assay ◽  
Blood Assay ◽  
Great Heterogeneity ◽  
Inhibitory Activities ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

The capacity to down-regulate the production of IL-8 by LPS-activated human polymorphonuclear cells (PMN) has been demonstrated for IL-4, IL-10, and TGFβ. We compared their relative capacities and further extended this property to IL-13. We report a great heterogeneity among individuals related to the responsiveness of PMN to the IL-4 and IL-13 inhibitory effects while their response to the IL-10 effect was homogenous. The inhibitory activities were observed at the transcriptional level. IL-8 induction by TNFα was, unlike its induction by LPS, resistant to the inhibitory effects of IL-10, IL-4, IL-13 and TGFβ. Furthermore, IL-10 and IL-4 inhibitory activity were less effective when TNFα was acting synergistically with LPS to induce IL-8 production by PMN. LPS-induced cell-associated IL-8, detected in the PMN cultures, could be marginally inhibited by IL-4 and IL-10. Altogether, our data demonstrate that IL-13 is able to inhibit LPS-induced IL-8 production by human PMN, although IL-10 remains the most active anti-inflammatory cytokine. Despite the capacity of IL-4, IL-10, and IL-13 to limit the production of TNFα-induced IL-8 in a whole blood assay, none was able to inhibit this production when studying isolated human polymorphonuclear cells.

Anti-inflammatory cytokine profile and mortality in febrile patients

The Lancet ◽  
1998 ◽  
Vol 351 (9107) ◽  
pp. 950-953 ◽  
Author(s):  
J VANDISSEL ◽  
P VANLANGEVELDE ◽  
R WESTENDORP ◽  
K KWAPPENBERG ◽  
M FROLICH
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Profile ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Why does anti-inflammatory cytokine levels increase during memory acquisition?

Neuroscience ◽  
2021 ◽  
Author(s):  
Sergei G. Levin ◽  
Ekaterina V. Pershina ◽  
Nickolay A. Bugaev-Makarovskiy ◽  
Irina Yu. Chernomorets ◽  
Maxim V. Konakov ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Levels ◽  
Memory Acquisition ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals The Anti-inflammatory Cytokine, Interleukin (IL)-10, Blocks the Inhibitory Effect of IL-1β on Long Term Potentiation

2001 ◽  
Vol 276 (49) ◽  
pp. 45564-45572 ◽  
Author(s):  
Áine Kelly ◽  
Aileen Lynch ◽  
Emily Vereker ◽  
Yvonne Nolan ◽  
Patrice Queenan ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Long Term Potentiation ◽  
Inhibitory Effect ◽  
Term Potentiation ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist

1994 ◽  
Vol 106 (3) ◽  
pp. 637-642 ◽  
Author(s):  
John C. Mansfield ◽  
Hazel Holden ◽  
Joanna K. Tarlow ◽  
Francesco S. Di Giovine ◽  
Tarra L. McDowell ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Receptor Antagonist ◽  
Genetic Association ◽  
Inflammatory Cytokine ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine
Sign in / Sign up

Export Citation Format

Share Document