Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase

2018 ◽  
Vol 81 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Navneet Kishore ◽  
Danielle Twilley ◽  
Analike Blom van Staden ◽  
Praveen Verma ◽  
Bikram Singh ◽  
...  
Keyword(s):  
Flavonoid Glycosides ◽  
Mushroom Tyrosinase ◽  
Inhibitory Activities ◽  
Myrsine Africana

scholarly journals Isolation, Characterization and Antioxidant, Tyrosinase Inhibitory Activities of Constituents from the Flowers of Cercis glabra ‘Spring-1’

2021 ◽  
Vol 15 (4) ◽  
pp. 254-260
Author(s):  
Penghua Shu ◽  
Yamin Li ◽  
Yuehui Luo ◽  
Shujing Cai ◽  
Yingying Fei ◽  
...  
Keyword(s):  
Radical Scavenging ◽  
Mushroom Tyrosinase ◽  
Dpph Radical ◽  
Inhibitory Effects ◽  
Isolation And Identification ◽  
Phytochemical Study ◽  
Inhibitory Activities ◽  
Dpph Radical Scavenging ◽  
In Vitro Antioxidant Activity

A phytochemical study on the flowers of Cercis glabra ‘Spring-1’ led to the isolation and identification of twelve compounds, including one new compound named as 1-O-α-l-rhamnosyl-(E)-phytol (1) and eleven known compounds. Their structures were elucidated based on physical data analysis, including HR-ESI-MS, NMR, UV, IR, and acid hydrolysis. All compounds were screened for in vitro antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl method. Compounds 4 and 5 exhibited obvious DPPH radical scavenging activities. All the isolates were tested for their inhibitory effects on mushroom tyrosinase, and compounds 6, 7, 10 and 11 showed moderate tyrosinase inhibitory activities.

Inhibitory activities of selected medicinal plants on mushroom tyrosinase

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
F Namjooyan ◽  
H Moosavi ◽  
A Jahangiri ◽  
M Azemi
Keyword(s):  
Medicinal Plants ◽  
Mushroom Tyrosinase ◽  
Inhibitory Activities

Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase

2016 ◽  
Vol 79 (12) ◽  
pp. 3065-3071 ◽  
Author(s):  
Batsukh Odonbayar ◽  
Toshihiro Murata ◽  
Javzan Batkhuu ◽  
Kosho Yasunaga ◽  
Rina Goto ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Mushroom Tyrosinase ◽  
Inhibitory Activities

scholarly journals Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

Medicines ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 113 ◽  
Author(s):  
Amina Ibrahim Dirar ◽  
Mikiyo Wada ◽  
Takashi Watanabe ◽  
Hari Prasad Devkota
Keyword(s):  
Free Radical ◽  
Phenolic Compounds ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Mushroom Tyrosinase ◽  
Aerial Parts ◽  
Inhibitory Activities ◽  
Potent Inhibitory Activity

Background: Blepharis linariifolia Pers. (Family: Acanthaceae) is used in traditional medicines as a general tonic and for the treatment of various health problems in Sudan. The main aim of this study was to isolate and identify the major chemical constituents from the aerial parts of B. linariifolia and evaluate their bioactivities. Methods: The dried aerial parts of the plant were extracted successively with 100% acetone and 50% acetone, and thereafter the combined extract was subjected to repeated column chromatography to isolate the main components. Free radical scavenging activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical method, and in vitro enzyme inhibitory activities against α-glucosidase, pancreatic lipase, and mushroom tyrosinase were evaluated. Results: From the detailed chemical analysis, verbascoside (1), vanillic acid (2), apigenin (3), and 6″-O-p-coumaroylprunin (4), were isolated and their structures were identified on the basis of their nuclear magnetic resonance (NMR) spectral data. Among the isolated compounds, verbascoside (1) showed the most potent free radical scavenging activity (IC50 = 22.03 ± 0.04 μM). Apigenin (3) and 6″-O-p-coumaroylprunin (4) showed promising inhibitory activities against all tested enzymes. Apigenin (3) showed the most potent inhibitory activity against α-glucosidase and tyrosinase (IC50 = 34.73 ± 1.78 μM and 23.14 ± 1.83 μM, respectively), whereas 6″-O-p-coumaroylprunin (4) showed potent inhibition for lipase (IC50 = 2.25 ± 0.17 μM). Conclusions: Four phenolic compounds were isolated and identified from B. linariifolia acetone extract, which are reported for the first time from this plant. All compounds showed good DPPH free radical scavenging activities, with verbascoside (1) being the most potent. Apigenin (3) was the most active as α-glucosidase and mushroom tyrosinase inhibitor, while 6″-O-p-coumaroylprunin (4) showed potent inhibitory activity for pancreatic lipase.

scholarly journals Isolation of Isocoumarins and Flavonoids as α-Glucosidase Inhibitors from Agrimonia pilosa L.

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2572
Author(s):  
Mi Jin Park ◽  
Young-Hwa Kang
Keyword(s):  
Kinetic Analysis ◽  
Competitive Inhibition ◽  
Flavonoid Compound ◽  
Flavonoid Glycosides ◽  
Phytochemical Study ◽  
Glucosidase Inhibitors ◽  
Key Factor ◽  
Ic50 Values ◽  
Inhibitory Activities ◽  
First Time

Agrimonia pilosa L. (AP) showed potent α-glucosidase inhibitory (AGI) activity, but it is uncertain what phytochemicals play a key factor. The phytochemical study of AP based on AGI activity led to the isolation of four isocoumarins; agrimonolide (1), agrimonolide-6-O-β-d-glucopyranoside (2), desmethylagrimonolide (3), desmethylagrimonolide-6-O-β-d-glucopyranoside (4), and four flavonoids; luteolin (5), quercetin (6), vitexin (7), and isovitexin (8). The four isocoumarins were isolated as α-glucosidase inhibitors for the first time. Isocoumarins, compound 1 (agrimonolide) and 3 (desmethylagrimonolide) showed strong α-glucosidase inhibitory activities with IC50 values of 24.2 and 37.4 µM, respectively. Meanwhile, isocoumarin and flavonoid glycosides showed weak AGI activity. In the kinetic analysis, isocoumarins, compounds 1 and 3 showed non-competitive inhibition, whereas flavonoid, compound 6 showed competitive inhibition.

scholarly journals Synthesis and Characterization of Coordinatively Unsaturated Copper (II) Complexes of 1,3-Bis(2'-Pyridyl)-1,2-Diaza-2-Butene and Their Antityrosinase Activity

1998 ◽  
Vol 5 (2) ◽  
pp. 59-66 ◽  
Author(s):  
Ratnamala Bendre ◽  
Anupa Murugkar ◽  
Subhash Padhye ◽  
Pallavi Kulkarni ◽  
Meena Karve
Keyword(s):  
Synthesis And Characterization ◽  
Mushroom Tyrosinase ◽  
Antityrosinase Activity ◽  
Inhibitory Activities ◽  
Tyrosinase Enzyme

The coordinatively unsaturated copper (II) complexes of 1,3-bis(2'-pyridyl)-1,2-diaza-2- butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature and extent of inhibition is modulated according to the type of ancillary anions.

Concise synthesis and antidiabetic activity of natural flavonoid glycosides, oroxins C and D, isolated from the seeds of Oroxylum indium

2020 ◽  
pp. 174751982092796 ◽  
Author(s):  
Gang Li ◽  
Guanghui Wang ◽  
Yangliu Tong ◽  
Junheng Zhu ◽  
Tongtong Yun ◽  
...  
Keyword(s):  
Natural Products ◽  
Inhibitory Activity ◽  
Antidiabetic Activity ◽  
Flavonoid Glycosides ◽  
Strong Inhibition ◽  
Oroxylum Indicum ◽  
Inhibitory Activities ◽  
Lipase Inhibition

The first concise synthesis of natural flavonoid glycosides, oroxins C (1) and D (2), which were isolated from the seeds of Oroxylum indicum, was efficiently achieved by a convergent strategy. The synthesized natural products 1 and 2 were evaluated for their inhibitory activities against α-glucosidase, α-amylase, and lipase. Compound 1 showed strong α-amylase and lipase inhibition, with IC50 values of 210 and 190 μM, respectively, but exhibited no inhibitory activity against α-glucosidase. Compound 2 showed strong inhibition against α-glucosidase and lipase, with the respective IC50 values of 180 and 80 μM.

scholarly journals Isolation and Characterization of Glycosidic Tyrosinase Inhibitors from Typhonium giganteum Rhizomes

2021 ◽  
Vol 15 (5) ◽  
pp. 380-387
Author(s):  
Penghua Shu ◽  
Huiqing Zhu ◽  
Wanrong Liu ◽  
Lingxiang Zhang ◽  
Junping Li ◽  
...  
Keyword(s):  
Positive Control ◽  
Mushroom Tyrosinase ◽  
Phenylethanoid Glycosides ◽  
Etoh Extract ◽  
Isolation And Characterization ◽  
Megastigmane Glycosides ◽  
Lignan Glycoside ◽  
Tyrosinase Inhibitors ◽  
Inhibitory Activities

A new hydrocinnamoyl glucoside, 1-O-(4-hydroxyhydrocinnamoyl)-β-D-glucopyranose (1), together with fifteen known glycosides, including two phenylethanoid glycosides (2–3), two cinnamoyl glycosides (4–5), six phenolic glycosides (6–11), one lignan glycoside (12) and four megastigmane glycosides (13–16) were isolated from a 95% EtOH extract of the Typhonium giganteum rhizomes. The sixteen glycosides were structurally characterized by NMR, HRESIMS, enzymatic hydrolysis and comparison with literature. Upon evaluating inhibitory activities of compounds 1–16 against mushroom tyrosinase at 25 μM, compounds 10 and 11 exhibited obvious inhibitory activities, with %inhibition values of 20.94±0.59%, 23.28±1.09%, respectively, with arbutin used as the positive control (26.21±0.58%).

scholarly journals Evaluation of the Antihyperuricemic Activity of Phytochemicals fromDavallia formosanaby Enzyme Assay and Hyperuricemic Mice Model

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Chen-Yu Chen ◽  
Chi-Chang Huang ◽  
Keng-Chang Tsai ◽  
Wei-Jan Huang ◽  
Wen-Ching Huang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Enzyme Assay ◽  
Critical Factor ◽  
Serum Urate ◽  
Flavonoid Glycosides ◽  
Mice Model ◽  
Inhibitory Activities ◽  
Potassium Oxonate

Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect ofDavallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C-β-d-glucopyranoside (1), 6,8,3′,4′-tetrahydroxyflavanone-7-C-β-d-glucopyranoside (2), 6,8,4′-trihydroxyflavanone-7-C-β-d-glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O-β-d-allopyranoside (4), and epiphyllocoumarin-3-O-β-d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds3and5significantly inhibited XOD activityin vitroand reduced serum uric acid levelsin vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.

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