Extended Concerted Rotation Technique Enhances the Sampling Efficiency of the Computational Peptide-Design Algorithm

2017 ◽  
Vol 13 (11) ◽  
pp. 5709-5720 ◽  
Author(s):  
Xingqing Xiao ◽  
Yiming Wang ◽  
Joshua N. Leonard ◽  
Carol K. Hall
2005 ◽  
Vol 19 (8) ◽  
pp. 585-601 ◽  
Author(s):  
Ignasi Belda ◽  
Sergio Madurga ◽  
Xavier Llorà ◽  
Marc Martinell ◽  
Teresa Tarragó ◽  
...  

2010 ◽  
Author(s):  
Jana Kesavan ◽  
Deborah Schepers ◽  
Tiffany Sutton ◽  
Paul Deluca ◽  
Michael Williamson ◽  
...  

2006 ◽  
Vol 5 (1) ◽  
pp. 77-79 ◽  
Author(s):  
Charles G. Crabtree ◽  
Tina M. Seaman

2019 ◽  
Vol 20 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Zhongyan Li ◽  
Qingqing Miao ◽  
Fugang Yan ◽  
Yang Meng ◽  
Peng Zhou

Background:Protein–peptide recognition plays an essential role in the orchestration and regulation of cell signaling networks, which is estimated to be responsible for up to 40% of biological interaction events in the human interactome and has recently been recognized as a new and attractive druggable target for drug development and disease intervention.Methods:We present a systematic review on the application of machine learning techniques in the quantitative modeling and prediction of protein–peptide binding affinity, particularly focusing on its implications for therapeutic peptide design. We also briefly introduce the physical quantities used to characterize protein–peptide affinity and attempt to extend the content of generalized machine learning methods.Results:Existing issues and future perspective on the statistical modeling and regression prediction of protein– peptide binding affinity are discussed.Conclusion:There is still a long way to go before establishment of general, reliable and efficient machine leaningbased protein–peptide affinity predictors.


2021 ◽  
pp. 101316
Author(s):  
Wataru Yanagihara ◽  
Hiroshi Kashimura ◽  
Yosuke Akamatsu ◽  
Jun Yoshida ◽  
Daigo Kojima

2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Ayaz Ahmad ◽  
L. Rajaji ◽  
A. Iqbal

AbstractDistributed generators are playing a vital role in supporting the grid in ever-increasing energy demands. Grid code regulation must be followed when integrating the photovoltaic inverter system to the grid. The paper investigates and analyzes a controller model for grid-connected PV inverters to inject sinusoidal current to the grid with minimum distortion. To achieve better tracking and disturbance rejection, a DSP-based current controller is designed with LCL filter. The controller gets the current feedback from the grid, compares it with reference current, and calculates duty cycle to generate PWM pulses to trigger H-bridge converters. The grid voltage is loaded to the initial value in proposed PR controller to ensure the initial inverter voltage to match the grid voltage. The paper presents a novel current controller algorithm for grid-connected inverter system, and simulation is done. A detailed analysis has been carried out to validate the proposed design algorithm. Experimental implementation of the current controller in the DC/AC converter circuits with an LCL filter is done for 5.4 kW to validate and match the simulation model.


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