scholarly journals Impact of the Nucleosome Histone Core on the Structure and Dynamics of DNA-Containing Pyrimidine–Pyrimidone (6–4) Photoproduct

2020 ◽  
Vol 16 (9) ◽  
pp. 5972-5981
Author(s):  
Eva Matoušková ◽  
Emmanuelle Bignon ◽  
Victor E. P. Claerbout ◽  
Tomáš Dršata ◽  
Natacha Gillet ◽  
...  
Keyword(s):  
Structure And Dynamics ◽  
Histone Core

Structure and dynamics of the yeast SWR1-nucleosome complex

Science ◽  
2018 ◽  
Vol 362 (6411) ◽  
pp. eaat7716 ◽  
Author(s):  
Oliver Willhoft ◽  
Mohamed Ghoneim ◽  
Chia-Liang Lin ◽  
Eugene Y. D. Chua ◽  
Martin Wilkinson ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Adenosine Triphosphate ◽  
Single Molecule ◽  
Conformational Changes ◽  
Base Pair ◽  
Histone H2a ◽  
Substrate Interactions ◽  
Structure And Dynamics ◽  
Cryo Electron Microscopy ◽  
Histone Core

The yeast SWR1 complex exchanges histone H2A in nucleosomes with Htz1 (H2A.Z in humans). The cryo–electron microscopy structure of the SWR1 complex bound to a nucleosome at 3.6-angstrom resolution reveals details of the intricate interactions between components of the SWR1 complex and its nucleosome substrate. Interactions between the Swr1 motor domains and the DNA wrap at superhelical location 2 distort the DNA, causing a bulge with concomitant translocation of the DNA by one base pair, coupled to conformational changes of the histone core. Furthermore, partial unwrapping of the DNA from the histone core takes place upon binding of nucleosomes to SWR1 complex. The unwrapping, as monitored by single-molecule data, is stabilized and has its dynamics altered by adenosine triphosphate binding but does not require hydrolysis.

Nucleosome dynamics

2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  
Keyword(s):  
High Resolution ◽  
Chromatin Structure ◽  
Current Knowledge ◽  
Dynamic Properties ◽  
Structure And Dynamics ◽  
Nucleosome Dynamics ◽  
Sharp Focus ◽  
Recent Advances ◽  
Insight Into ◽  
Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

Structure and dynamics of phosphate glasses

1998 ◽  
Vol 77 (2) ◽  
pp. 357-362 ◽  
Author(s):  
A. Matic, L. Borjesson
Keyword(s):  
Phosphate Glasses ◽  
Structure And Dynamics

Studies of the structure and dynamics of theDregion of the polar ionosphere during solar flares in April 2004

2006 ◽  
Vol 6 (2) ◽  
Author(s):  
V. D. Tereshchenko ◽  
E. B. Vasil'ev ◽  
O. F. Ogloblina ◽  
V. A. Tereshchenko ◽  
S. M. Chernyakov
Keyword(s):  
Solar Flares ◽  
Polar Ionosphere ◽  
Structure And Dynamics
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