scholarly journals Toward High-Throughput Predictive Modeling of Protein Binding/Unbinding Kinetics

2016 ◽  
Vol 56 (6) ◽  
pp. 1164-1174 ◽  
Author(s):  
See Hong Chiu ◽  
Lei Xie
Keyword(s):  
Protein Binding ◽  
Predictive Modeling ◽  
High Throughput

scholarly journals Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening

2016 ◽  
Vol 17 (4) ◽  
pp. 1008-1019 ◽  
Author(s):  
C. Damon ◽  
M. Luck ◽  
L. Toullec ◽  
I. Etienne ◽  
M. Buchler ◽  
...  
Keyword(s):  
Predictive Modeling ◽  
High Throughput ◽  
Genetic Screening ◽  
Dose Requirement ◽  
Tacrolimus Dose

scholarly journals Protein Binding Pocket Optimization for Virtual High-Throughput Screening (vHTS) Drug Discovery

ACS Omega ◽  
2020 ◽  
Vol 5 (24) ◽  
pp. 14297-14307 ◽  
Author(s):  
Dimitris Gazgalis ◽  
Mehreen Zaka ◽  
Bilal Haider Abbasi ◽  
Diomedes E. Logothetis ◽  
Mihaly Mezei ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Binding ◽  
High Throughput ◽  
High Throughput Screening ◽  
Binding Pocket

scholarly journals PESDserv: a server for high-throughput comparison of protein binding site surfaces

2010 ◽  
Vol 26 (15) ◽  
pp. 1913-1914 ◽  
Author(s):  
S. Das ◽  
M. P. Krein ◽  
C. M. Breneman
Keyword(s):  
Protein Binding ◽  
Binding Site ◽  
High Throughput ◽  
Protein Binding Site

High-Throughput Detection of Ligand-Protein Binding Using a SplitLuc Cellular Thermal Shift

2021 ◽  
pp. 21-41
Author(s):  
Tino W. Sanchez ◽  
Ashley Owens ◽  
Natalia J. Martinez ◽  
Eric Wallgren ◽  
Anton Simeonov ◽  
...  
Keyword(s):  
Protein Binding ◽  
High Throughput ◽  
High Throughput Detection ◽  
Thermal Shift

scholarly journals Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2910
Author(s):  
Ewa A. Grzybowska ◽  
Maciej Wakula
Keyword(s):  
Protein Binding ◽  
High Throughput ◽  
Mrna Stability ◽  
Regulatory Network ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Translational Efficiency ◽  
Coding Sequence ◽  
Transcript Stability ◽  
Coding Regions

Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the functions thereof are more obscure. As described in this review, CDS binding has a role in the regulation of mRNA stability, but it has also a more intriguing role in the regulation of translational efficiency. Global approaches, which suggest the significance of CDS binding along with specific examples of CDS-binding RBPs and their modes of action, are outlined here, pointing to the existence of a relatively less-known regulatory network controlling mRNA stability and translation on yet another level.

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