Ligand-Based Virtual Screening in a Search for Novel Anti-HIV-1 Chemotypes

2015 ◽  
Vol 55 (10) ◽  
pp. 2168-2177 ◽  
Author(s):  
Agata Kurczyk ◽  
Dawid Warszycki ◽  
Robert Musiol ◽  
Rafał Kafel ◽  
Andrzej J. Bojarski ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Anti Hiv ◽  
Hiv 1

Virtual Screening for Anti-HIV-1 RT and Anti-HIV-1 PR Inhibitors from the Thai Medicinal Plants Database: A Combined Docking with Neural Networks Approach

2005 ◽  
Vol 8 (5) ◽  
pp. 417-429 ◽  
Author(s):  
Chak Sangma ◽  
Daungmanee Chuakheaw ◽  
Nipa Jongkon ◽  
Kittipong Saenbandit ◽  
Peerapol Nunrium ◽  
...  
Keyword(s):  
Neural Networks ◽  
Virtual Screening ◽  
Medicinal Plants ◽  
Thai Medicinal Plants ◽  
Anti Hiv ◽  
Hiv 1

In Silico Investigation of a HIV-1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti-HIV Drug Design

2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Sy Bing Choi ◽  
Yee Siew Choong ◽  
Akiko Saito ◽  
Habibah A. Wahab ◽  
Nazalan Najimudin ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Drug Design ◽  
Binding Site ◽  
In Silico ◽  
Inhibitor Binding ◽  
Anti Hiv ◽  
Hiv 1

Anticardiolipin Antibodies Are Elevated in HIV-1 Infected Haemophiliacs but Do Not Predict for Disease Progression

1989 ◽  
Vol 61 (01) ◽  
pp. 081-085 ◽  
Author(s):  
Simon Panzer ◽  
Christoph Stain ◽  
Hubert Hartl ◽  
Robert Dudczak ◽  
Klaus Lechner
Keyword(s):  
Normal Values ◽  
Anticardiolipin Antibodies ◽  
Haemophilia A ◽  
Serum Samples ◽  
Factor Viii Concentrates ◽  
Patient Groups ◽  
Anti Hiv ◽  
Hiv 1 ◽  
Cd4 Lymphocytes

SummaryLevels of anticardiolipin antibodies (ACA) were measured in 55 patients with haemophilia A in serum samples obtained in 1983 and in 1987. Twenty-one patients were negative for anti HIV-1 antibodies in 1983 and remained negative in 1987; 34 patients had anti HIV-1 antibodies in 1983; 17 of these latter patients remained asymptomatic, whereas 17 patients developed ARC or AIDS during the 4 years follow-up. Thirteen anti HIV-1 negative patients had elevated ACA levels in 1983; subsequently, a significant decrease was observed in all these subjects (p <0.001). All anti HIV-1 positive patients had elevated ACA levels in 1983; normal values were found in 9 patients in 1987. Yet, these changes were not significant (p >0.05). ACA levels were significantly higher in HIV-1 infected patients than in those without anti HIV-1 antibodies (p <0.05). There was no difference of ACA levels between the two anti HIV-1 positive patient groups, be it in 1983 or be it in 1987 (p >0.05). There was no correlation of ACA levels with serum IgG concentrations, CD4+ lymphocytes, or the consumption of factor VIII concentrates.

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