Solubility Measurement and Correlation for ε-2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane in Different Alkanes/Aromatic Hydrocarbon + Ethyl Acetate Binary Solvents at Temperatures of between 283.15 and 323.15 K

2018 ◽  
Vol 63 (8) ◽  
pp. 3097-3106 ◽  
Author(s):  
Chao Cui ◽  
Hui Ren ◽  
Qingjie Jiao
Keyword(s):  
Aromatic Hydrocarbon ◽  
Ethyl Acetate ◽  
Binary Solvents ◽  
Solubility Measurement

scholarly journals Anti-hypercholesterolemic agent from Indonesian rice bran

2019 ◽  
Vol 10 (4) ◽  
pp. 2733-2738
Author(s):  
Syaikhul Aziz ◽  
Elfahmi ◽  
Andreanus Andaja Soemardji ◽  
Sukrasno
Keyword(s):  
Solvent Extraction ◽  
Ethyl Acetate ◽  
Mass Spectroscopy ◽  
Rice Bran ◽  
Total Cholesterol Level ◽  
Hexane Extract ◽  
Binary Solvents ◽  
Serum Total Cholesterol Level ◽  
Isolated Compound ◽  
Acetone Hexane

This research was conducted to determine the total oryzanol content of various extracts and bioassay-guided isolation of active anti-hypercholesterolemic agent from Indonesian rice bran. Hot solvent extraction was done by reflux method using single and binary solvents, namely hexane, chloroform, ethyl acetate, dichloromethane, isopropanol, acetone, hexane-ethyl acetate (1:1, v/v), hexane-isopropanol (1:1, v/v), and chloroform-ethyl acetate (1:1, v/v). TLC densitometric was used to quantitatively analyze the total oryzanol content in various extracts. The hexane extract was selected for fractionation and evaluated for their anti-hypercholesterolemic activity. The structure of an isolated compound was determined on the basis of NMR and Mass spectroscopy. The total oryzanol content was obtained using various solvents ranging from 27.92 to 43.59 mg/100g rice bran, in which hexane extract showed the highest amount (43.59 ± 3.36 mg/100g rice bran). β-sitosterol has been isolated from rice bran hexane extract, which shows a significant decrease in serum total cholesterol level. In summary, hexane is the best solvent to extract oryzanol compound using reflux method, and β-sitosterol was suspected to be responsible for anti-hypercholesterolemic activity in addition to existing compound such as oryzanol that contained in the rice bran.

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