Solubility Behavior of N-Carbobenzyloxyglycine in 14 Individual Solvents at Temperatures Ranging from 283.15 to 323.15 K

2021 ◽  
Author(s):  
Haishuang Huang ◽  
Jingxuan Qiu ◽  
Hui He ◽  
Ying Guo ◽  
Shen Hu ◽  
...  
Keyword(s):  
Solubility Behavior

scholarly journals Investigation of Solubility Behavior of Canagliflozin Hydrate Crystals Combining Crystallographic and Hirshfeld Surface Calculations

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 298
Author(s):  
Yefen Zhu ◽  
Yanlei Kang ◽  
Ling Zhu ◽  
Kaxi Yu ◽  
Shuai Chen ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Intermolecular Forces ◽  
Hirshfeld Surface ◽  
Reversible Inhibitor ◽  
Solubility Behavior ◽  
Hydrogen Bond Networks ◽  
Solvent Molecules ◽  
First Time ◽  
Better Than

Canagliflozin (CG) was a highly effective, selective and reversible inhibitor of sodium-dependent glucose co-transporter 2 developed for the treatment of type 2 diabetes mellitus. The crystal structure of CG monohydrate (CG-H2O) was reported for the first time while CG hemihydrate (CG-Hemi) had been reported in our previous research. Solubility and dissolution rate results showed that the solubility of CG-Hemi was 1.4 times higher than that of CG-H2O in water and hydrochloric acid solution, and the dissolution rates of CG-Hemi were more than 3 folds than CG-H2O in both solutions. Hirshfeld surface analysis showed that CG-H2O had stronger intermolecular forces than CG-Hemi, and water molecules in CG-H2O participated three hydrogen bonds, forming hydrogen bond networks. These crystal structure features might make it more difficult for solvent molecules to dissolve CG-H2O than CG-Hemi. All these analyses might explain why the dissolution performance of CG-Hemi was better than CG-H2O. This work provided an approach to predict the dissolution performance of the drug based on its crystal structure.

Solubility behavior of titanium(IV) oxide in alkaline media at elevated temperatures

1993 ◽  
Vol 22 (7) ◽  
pp. 601-623 ◽  
Author(s):  
S. E. Ziemniak ◽  
M. E. Jones ◽  
K. E. S. Combs
Keyword(s):  
Elevated Temperatures ◽  
Alkaline Media ◽  
Solubility Behavior

Solubility Behavior of CO2 in Ionic Liquids Based on Ionic Polarity Index Analyses

2021 ◽  
Author(s):  
Xiaoyang Liu ◽  
Kathryn E. O’Harra ◽  
Jason E. Bara ◽  
C. Heath Turner
Keyword(s):  
Ionic Liquids ◽  
Solubility Behavior ◽  
Polarity Index

scholarly journals Thermodynamic Investigations on the Inclusion Complexation of Piroxicam with Cyclodextrin Derivatives

2005 ◽  
Vol 73 (3) ◽  
pp. 147-161 ◽  
Author(s):  
Charumanee S. ◽  
Weiss-Greiler P. ◽  
Wolschann P. ◽  
Viernstein H. ◽  
Titwan A. ◽  
...  
Keyword(s):  
Ph Value ◽  
Equilibrium Constants ◽  
Inclusion Complexation ◽  
Solubility Diagram ◽  
Phase Solubility ◽  
Cyclodextrin Derivatives ◽  
Ph Values ◽  
Solubility Behavior ◽  
Solubility Method ◽  
Different Temperatures

Thermodynamic studies of piroxicam in aqueous solution complexed with β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and two β-cyclodextrin derivatives, hydroxypropyl-β-cyclodextrin (HP-P-CD) and methyl-β-cyclodextrin (Me-β-CD) were performed at different temperatures and pH values using the phase solubility method. The phase solubility diagrams of β-CD, γ-CD and HP-β-CD is of AL-type behavior, indicating the formation of 1:l complexes. The related stability constants range from β-CD > γ-CD > Me-β-CD > HP-β-CD, respectively. An Ap-type solubility diagram is observed for Me-β-CD, indicating the formation of 1:2 complexes at higher CD concentrations. From the temperature dependence of the equilibrium constants the reaction enthalpies and entropies have been determined. The contributions of the reaction entropies are small and no enthalpy-entropy-compensation is observed, except for γ-CD, where a very small negative reaction entropy could be estimated. Moreover, the influence of the pH value is rather high because the differently charged forms of piroxicam show different solubility behavior in water.

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